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Proteins and peptidesAnti-Ly6g antibody [1A8] - mouse IgG2c (Chimeric)
Low endotoxin, Azide free.
Our first-to-market chimera with mouse IgG2c backbone, this functional antibody specifically depletes neutrophils in vivo for up to 72h.
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MW 622.8 Da. Highly potent, selective vacuolar (V)-ATPase inhibitor (IC50 = 500 pM in chromaffin granule membranes). Induces vacuolar deacidification and promotes apoptosis.
88899-55-2
Solid
Streptomyces griseus
622.8 Da
C35H58O9
6436223
Native
1110033K02Rik, 16A, A3AR, A3R, AA3R_HUMAN, AD 026, ADORA 3, APP secretase, APPS, ARA3, ATP receptor, ATP6IP1, ATP6S1, ATPase H+ transporting lysosomal (vacuolar proton pump) subunit 1, ATPase H+ transporting lysosomal accessory protein 1, ATPase H+ transporting lysosomal interacting protein 1, Ac45, Adenosine A3 receptor, Adenosine receptor A3, Amyloid precursor protein secretase, B230344N16, CATB_HUMAN, CF2, CPSB, CTSB, Cathepsin B heavy chain, Cathepsin B1, CathepsinB, GPCR 2, H ATPase subunit, KIAA0881, Kinase from chicken homolog C, MAP3K17, MGC129781, MGC129956, ORF, OTTHUMP00000116009, OTTHUMP00000229510, OTTHUMP00000229511, OTTHUMP00000229512, OTTHUMP00000229514, OTTHUMP00000229515, OTTHUMP00000229516, P2RX3_HUMAN, P2X purinoceptor 3, P2X receptor subunit 3, PSK, PSK-1, PSK1 beta, Preprocathepsin B, Prostate derived STE20 like kinase PSK, Prostate derived sterile 20 like kinase 1, Prostate-derived STE20-like kinase 1, Protein XAP 3, Purinergic receptor, Purinergic receptor P2X ligand gated ion channel 3, Purinergic receptor P2X3, Purinoceptor P2X3, RP11 552M11.7, Serine/threonine-protein kinase TAO2, TAO 1, TAO 2, TAO kinase 2, TAOK2_HUMAN, TGPCR1, Thousand and one amino acid protein 2, Thousand and one amino acid protein kinase, UNQ2971/PRO7431, V ATPase Ac45 subunit, V ATPase S1 accessory protein, V ATPase subunit S1, V type proton ATPase subunit S1, VATPS1, Vacuolar ATP synthase subunit S1, Vacuolar proton pump subunit S1, XAP 3, bA552M11.5, cysteine protease, hKFC-C, mKIAA0881
MW 622.8 Da. Highly potent, selective vacuolar (V)-ATPase inhibitor (IC50 = 500 pM in chromaffin granule membranes). Induces vacuolar deacidification and promotes apoptosis.
1110033K02Rik, 16A, A3AR, A3R, AA3R_HUMAN, AD 026, ADORA 3, APP secretase, APPS, ARA3, ATP receptor, ATP6IP1, ATP6S1, ATPase H+ transporting lysosomal (vacuolar proton pump) subunit 1, ATPase H+ transporting lysosomal accessory protein 1, ATPase H+ transporting lysosomal interacting protein 1, Ac45, Adenosine A3 receptor, Adenosine receptor A3, Amyloid precursor protein secretase, B230344N16, CATB_HUMAN, CF2, CPSB, CTSB, Cathepsin B heavy chain, Cathepsin B1, CathepsinB, GPCR 2, H ATPase subunit, KIAA0881, Kinase from chicken homolog C, MAP3K17, MGC129781, MGC129956, ORF, OTTHUMP00000116009, OTTHUMP00000229510, OTTHUMP00000229511, OTTHUMP00000229512, OTTHUMP00000229514, OTTHUMP00000229515, OTTHUMP00000229516, P2RX3_HUMAN, P2X purinoceptor 3, P2X receptor subunit 3, PSK, PSK-1, PSK1 beta, Preprocathepsin B, Prostate derived STE20 like kinase PSK, Prostate derived sterile 20 like kinase 1, Prostate-derived STE20-like kinase 1, Protein XAP 3, Purinergic receptor, Purinergic receptor P2X ligand gated ion channel 3, Purinergic receptor P2X3, Purinoceptor P2X3, RP11 552M11.7, Serine/threonine-protein kinase TAO2, TAO 1, TAO 2, TAO kinase 2, TAOK2_HUMAN, TGPCR1, Thousand and one amino acid protein 2, Thousand and one amino acid protein kinase, UNQ2971/PRO7431, V ATPase Ac45 subunit, V ATPase S1 accessory protein, V ATPase subunit S1, V type proton ATPase subunit S1, VATPS1, Vacuolar ATP synthase subunit S1, Vacuolar proton pump subunit S1, XAP 3, bA552M11.5, cysteine protease, hKFC-C, mKIAA0881
88899-55-2
Solid
Streptomyces griseus
622.8 Da
C35H58O9
6436223
Native
bafilomycin A1
Highly potent, selective vacuolar (V)-ATPase inhibitor (IC50 = 500 pM in chromaffin granule membranes). Induces vacuolar deacidification and promotes apoptosis.
CC1CC(=CC=CC(C(OC(=O)C(=CC(=CC(C1O)C)C)OC)C(C)C(C(C)C2(CC(C(C(O2)C(C)C)C)O)O)O)OC)C
C[C@H]1C/C(=C/C=C/[C@@H]([C@H](OC(=O)/C(=C/C(=C/[C@H]([C@H]1O)C)/C)/OC)[C@@H](C)[C@H]([C@H](C)[C@]2(C[C@H]([C@@H]([C@H](O2)C(C)C)C)O)O)O)OC)/C
InChI=1S/C35H58O9/c1-19(2)32-24(7)27(36)18-35(40,44-32)26(9)31(38)25(8)33-28(41-10)14-12-13-20(3)15-22(5)30(37)23(6)16-21(4)17-29(42-11)34(39)43-33/h12-14,16-17,19,22-28,30-33,36-38,40H,15,18H2,1-11H3/b14-12+,20-13+,21-16+,29-17-/t22-,23+,24-,25-,26-,27+,28-,30-,31+,32+,33+,35+/m0/s1
XDHNQDDQEHDUTM-JQWOJBOSSA-N
(3Z,5E,7R,8S,9S,11E,13E,15S,16R)-16-[(2S,3R,4S)-4-[(2R,4R,5S,6R)-2,4-dihydroxy-5-methyl-6-propan-2-yloxan-2-yl]-3-hydroxypentan-2-yl]-8-hydroxy-3,15-dimethoxy-5,7,9,11-tetramethyl-1-oxacyclohexadeca-3,5,11,13-tetraen-2-one
Ambient - Can Ship with Ice
-20°C
Store under desiccating conditions, The product can be stored for up to 12 months
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ab240635 staining SQSTM1/p62 (autophagosome) in control HeLa cells (left panel) and SQSTM1/p62 in HeLa cells treated with 100nM bafilomycin A1 (ab120497) for 18hrs (right panel). The cells were fixed with methanol (5min), permeabilized with 0.1% Triton X-100 for 5 minutes and then blocked with 1% BSA/10% normal goat serum/0.3M glycine in 0.1% PBS-Tween for 1h. The cells were then incubated with ab240635 at 2ug/ml and ab7291 (Tubulin) at 1/1000 dilution overnight at +4°C, followed by a further incubation at room temperature for 1h with a goat secondary antibody to rabbit IgG (Alexa Fluor® 488) (ab150081) at 2 μg/ml (shown in green) and a goat secondary antibody to mouse IgG (Alexa Fluor® 594) (ab150120) at 2 μg/ml (shown in red). Nuclear DNA was labelled in blue with DAPI.
Image was acquired with a high-content analyser (Operetta CLS, Perkin Elmer) and a maximum intensity projection of confocal sections is shown.
ab109012 staining SQSTM1/p62 (autophagosome) in control HeLa cells (left panel) and SQSTM1/p62 in HeLa cells treated with 1uM bafilomycin A1 (ab120497) for 18hrs (right panel). The cells were fixed with methanol (5min), permeabilized with 0.1% Triton X-100 for 5 minutes and then blocked with 1% BSA/10% normal goat serum/0.3M glycine in 0.1% PBS-Tween for 1h. The cells were then incubated with ab109012 at 5ug/ml and ab7291 (Tubulin) at 1/1000 dilution overnight at +4°C, followed by a further incubation at room temperature for 1h with a goat secondary antibody to rabbit IgG (Alexa Fluor® 488) (ab150081) at 2 μg/ml (shown in green) and a goat secondary antibody to mouse IgG (Alexa Fluor® 594) (ab150120) at 2 μg/ml (shown in pseudo color red). Nuclear DNA was labelled in blue with DAPI.
Image was taken with a confocal microscope (Leica-Microsystems, TCS SP8).
2D chemical structure image of ab120497, Bafilomycin A1, (V)-ATPase inhibitor
ab155686 staining SQSTM1/p62 (autophagosome) in control HeLa cells (left panel) and SQSTM1/p62 in HeLa cells treated with 1uM bafilomycin A1 (ab120497) for 18hrs (right panel). The cells were fixed with methanol (5min), permeabilized with 0.1% Triton X-100 for 5 minutes and then blocked with 1% BSA/10% normal goat serum/0.3M glycine in 0.1% PBS-Tween for 1h. The cells were then incubated with ab155686 at 1/500 dilution and ab7291 (Tubulin) at 1/1000 dilution overnight at +4°C, followed by a further incubation at room temperature for 1h with a goat secondary antibody to rabbit IgG (Alexa Fluor® 488) (ab150081) at 2 μg/ml (shown in green) and a goat secondary antibody to mouse IgG (Alexa Fluor® 594) (ab150120) at 2 μg/ml (shown in pseudo color red). Nuclear DNA was labelled in blue with DAPI.
Image was taken with a confocal microscope (Leica-Microsystems, TCS SP8).
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