MW 270.24 g/mol, Purity >98%. Cell-permeable flavonoid. Lipoxygenase inhibitor (IC50 values are 0.64 and 1.6 μM at 12- and 15-lipoxygenases, respectively). Shows antioxidant and anti-inflammatory properties. Also induces apoptosis. Additionally, inhibits α-syn oligomerisation, β-Amyloid induced neurotoxicity and amyloid protein aggregation.
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Key facts
- CAS number
- 491-67-8
- Purity
- > 98%
- Form
- Solid
- Molecular weight
- 270.24 g/mol
- Molecular formula
- C15H10O5
- Nature
- Synthetic
Recommended products
MW 270.24 g/mol, Purity >98%. Cell-permeable flavonoid. Lipoxygenase inhibitor (IC50 values are 0.64 and 1.6 μM at 12- and 15-lipoxygenases, respectively). Shows antioxidant and anti-inflammatory properties. Also induces apoptosis. Additionally, inhibits α-syn oligomerisation, β-Amyloid induced neurotoxicity and amyloid protein aggregation.
Key facts
- CAS number
- 491-67-8
- Purity
- > 98%
- Form
- Solid
- Molecular weight
- 270.24 g/mol
- Molecular formula
- C15H10O5
- Nature
- Synthetic
- Solubility
Soluble in DMSO to 50 mM.
- Biological description
Cell-permeable flavonoid. Lipoxygenase inhibitor (IC50 values are 0.64 and 1.6 μM at 12- and 15-lipoxygenases, respectively). Shows antioxidant and anti-inflammatory properties. Also induces apoptosis. Additionally, inhibits α-syn oligomerisation, β-Amyloid induced neurotoxicity and amyloid protein aggregation.
- IUPAC name
- 5,6,7-Trihydroxy-2-phenyl-(4H)-1-benzopyran-4-one
Storage
- Shipped at conditions
- Ambient - Can Ship with Ice
- Appropriate short-term storage conditions
- -20°C
- Appropriate long-term storage conditions
- -20°C
- Storage information
- Store under desiccating conditions, The product can be stored for up to 12 months
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2 product images
Chemical Structure - Baicalein, Lipoxygenase inhibitor. (ab120723)
2D chemical structure image of ab120723, Baicalein, Lipoxygenase inhibitor.
Immunocytochemistry/ Immunofluorescence - Baicalein, Lipoxygenase inhibitor. (ab120723)
Anti-HIF-1 alpha antibody [EP1215Y] ab51608 staining HIF1α in HepG2 cells treated with baicalein (ab120723), by ICC/IF. Increase in HIF1α expression correlates with increased concentration of baicalein as described in literature.
The cells were incubated at 37°C for 6h in media containing different concentrations of ab120723 (baicalein) in DMSO, fixed with 4% formaldehyde for 10 minutes at room temperature and blocked with PBS containing 10% goat serum, 0.3 M glycine, 1% BSA and 0.1% tween for 2h at room temperature. Staining of the treated cells with Anti-HIF-1 alpha antibody [EP1215Y] ab51608 (5 µg/ml) was performed overnight at 4°C in PBS containing 1% BSA and 0.1% tween. A DyLight 488 goat anti-rabbit polyclonal antibody (Goat Anti-Rabbit IgG H&L (DyLight® 488) preadsorbed ab96899) at 1/250 dilution was used as the secondary antibody.
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