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AB120723

Baicalein, Lipoxygenase inhibitor.

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MW 270.24 g/mol, Purity >98%. Cell-permeable flavonoid. Lipoxygenase inhibitor (IC50 values are 0.64 and 1.6 μM at 12- and 15-lipoxygenases, respectively). Shows antioxidant and anti-inflammatory properties. Also induces apoptosis. Additionally, inhibits α-syn oligomerisation, β-Amyloid induced neurotoxicity and amyloid protein aggregation.
2 Images
Immunocytochemistry/ Immunofluorescence - Baicalein, Lipoxygenase inhibitor. (AB120723)
  • ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Baicalein, Lipoxygenase inhibitor. (AB120723)

ab51608 staining HIF1α in HepG2 cells treated with baicalein (ab120723), by ICC/IF. Increase in HIF1α expression correlates with increased concentration of baicalein as described in literature.
The cells were incubated at 37°C for 6h in media containing different concentrations of ab120723 (baicalein) in DMSO, fixed with 4% formaldehyde for 10 minutes at room temperature and blocked with PBS containing 10% goat serum, 0.3 M glycine, 1% BSA and 0.1% tween for 2h at room temperature. Staining of the treated cells with ab51608 (5 µg/ml) was performed overnight at 4°C in PBS containing 1% BSA and 0.1% tween. A DyLight 488 goat anti-rabbit polyclonal antibody (ab96899) at 1/250 dilution was used as the secondary antibody.

Chemical Structure - Baicalein, Lipoxygenase inhibitor. (AB120723)
  • Chemical Structure

Lab

Chemical Structure - Baicalein, Lipoxygenase inhibitor. (AB120723)

2D chemical structure image of ab120723, Baicalein, Lipoxygenase inhibitor.

Key facts

CAS number

491-67-8

Purity

>98%

Form

Solid

form

Molecular weight

270.24 g/mol

Molecular formula

C<sub>1</sub><sub>5</sub>H<sub>1</sub><sub>0</sub>O<sub>5</sub>

Nature

Synthetic

Solubility

Soluble in DMSO to 50 mM

Biological description

Cell-permeable flavonoid. Lipoxygenase inhibitor (IC50 values are 0.64 and 1.6 μM at 12- and 15-lipoxygenases, respectively). Shows antioxidant and anti-inflammatory properties. Also induces apoptosis. Additionally, inhibits α-syn oligomerisation, β-Amyloid induced neurotoxicity and amyloid protein aggregation.

IUPAC Name

5,6,7-Trihydroxy-2-phenyl-(4H)-1-benzopyran-4-one

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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
Store under desiccating conditions|The product can be stored for up to 12 months
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Product protocols

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