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AB144924

BAPTA, extracellular calcium chelator

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(2 Publications)

MW 476.4 Da. Selective, membrane impermeable extracellular calcium chelator. Binds Ca2+ ions in a 2:1 ratio. Shows 105-fold greater affinity for Ca2+ than Mg2+. BAPTA-AM (ab120503) and BAPTA sodium salt (ab120449) analog.

Key facts

CAS number

85233-19-8

Form

Powder

form

Molecular weight

476.4 Da

Molecular formula

C<sub>2</sub><sub>2</sub>H<sub>2</sub><sub>4</sub>N<sub>2</sub>O<sub>1</sub><sub>0</sub>

PubChem

104751

Nature

Synthetic

Solubility

Soluble in DMSO to 25 mM

Biochemical name

Bapta

Biological description

Selective, membrane impermeable extracellular calcium chelator. Binds Ca2+ ions in a 2:1 ratio. Shows 105-fold greater affinity for Ca2+ than Mg2+. BAPTA-AM (ab120503) and BAPTA sodium salt (ab120449) analog.

Canonical smiles

C1=CC=C(C(=C1)N(CC(=O)O)CC(=O)O)OCCOC2=CC=CC=C2N(CC(=O)O)CC(=O)O

InChi

InChI=1S/C22H24N2O10/c25-19(26)11-23(12-20(27)28)15-5-1-3-7-17(15)33-9-10-34-18-8-4-2-6-16(18)24(13-21(29)30)14-22(31)32/h1-8H,9-14H2,(H,25,26)(H,27,28)(H,29,30)(H,31,32)

InChiKey

FTEDXVNDVHYDQW-UHFFFAOYSA-N

IUPAC Name

2-[2-[2-[2-[bis(carboxymethyl)amino]phenoxy]ethoxy]-N-(carboxymethyl)anilino]acetic acid

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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
Store under desiccating conditions|The product can be stored for up to 12 months
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Product protocols

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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

The Journal of biological chemistry 295:10138-10152 PubMed32385113

2020

Intramitochondrial proteostasis is directly coupled to α-synuclein and amyloid β1-42 pathologies.

Applications

Unspecified application

Species

Unspecified reactive species

Janin Lautenschläger,Sara Wagner-Valladolid,Amberley D Stephens,Ana Fernández-Villegas,Colin Hockings,Ajay Mishra,James D Manton,Marcus J Fantham,Meng Lu,Eric J Rees,Clemens F Kaminski,Gabriele S Kaminski Schierle

Autophagy 13:2086-2103 PubMed28933598

2017

Autophagy gene ATG7 regulates ultraviolet radiation-induced inflammation and skin tumorigenesis.

Applications

Unspecified application

Species

Unspecified reactive species

Lei Qiang,Ashley Sample,Christopher R Shea,Keyoumars Soltani,Kay F Macleod,Yu-Ying He
View all publications
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Biochemicals

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