Batimastat (BB-94) (DMSO solution), Matrix metalloprotease (MMP) inhibitor
Be the first to review this product! Submit a review
|
(2 Publications)
MW 477.6 Da, Purity >98%. Potent, broad-spectrum MMP inhibitor (IC50 values are 3 (MMP-1), 4 (MMP-2), 4 (MMP-9), 6 (MMP-7), 20 nM (MMP-3)). Anticancer activity in vivo.
View Alternative Names
27 kDa interstitial collagenase, 72 kDa gelatinase, 72kD type IV collagenase, 82 kDa matrix metalloproteinase-9, 92 kDa gelatinase, 92 kDa type IV collagenase, BLAST-2, C-type lectin domain family 4, C-type lectin domain family 4 member J, CD 23, CD 23A, CD23 antigen, CHDS6, CLEC 4J, CLG, CLG 3, CLG 4, CLG 4A, CLG 4B, Collagenase 3, Collagenase Type 4 alpha, Collagenase Type 4 beta, Collagenase type IV 92 KD, Collagenase type IV A, EC 3.4.24.35, FCE 2, FCER2A, FCER2_HUMAN, Fc epsilon receptor II, Fc fragment of IgE, Fc fragment of IgE low affinity II receptor for, Fc fragment of IgE receptor II, Fc fragment of IgE, low affinity II, receptor for (CD23), Fc of IgE, Fc of IgE, low affinity II, receptor for (CD23), Fc receptor IgE low affinity II alpha polypeptide, Fc receptor, IgE, low affinity II, alpha polypeptide, isoform CRA_a, Fc-epsilon-RII, FceRII, Fibroblast collagenase, GELB, Gelatinase 92 KD, Gelatinase A, Gelatinase B, Gelatinase alpha, Gelatinase beta, Gelatinase neutrophil, IGEBF, IgE receptor lymphocyte, IgE-binding factor, Immunoglobulin E receptor, Immunoglobulin E receptor, low affinity II, Immunoglobulin E-binding factor, Immunoglobulin epsilon chain, Interstitial collagenase, LEUKOCYTE ANTIGEN CD23, Low Affinity IgE Receptor, Low affinity immunoglobulin epsilon Fc receptor, Low affinity immunoglobulin epsilon Fc receptor membrane bound form, Low affinity immunoglobulin epsilon Fc receptor soluble form, Ly-42, Lymphocyte IgE receptor, Lymphocyte antigen CD23, MANDP1, MANDP2, MGC126102, MGC126103, MGC126104, MGC93219, MMP II, MMP-X1, MMP13_HUMAN, MMP14_HUMAN, MMP1_HUMAN, MMP2_HUMAN, MMP3_HUMAN, MMP7_HUMAN, MMP9_HUMAN, MONA, MPSL1, MT-MMP 1, MT1-MMP, Macrophage gelatinase, Matrilysin, Matrin, Matrix Metalloproteinase 9, Matrix metallopeptidase 1 (interstitial collagenase), Matrix metallopeptidase 13 (collagenase 3), Matrix metallopeptidase 14 (membrane inserted), Matrix metallopeptidase 2 gelatinase A 72kDa gelatinase 72kDa type IV collagenase, Matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase), Matrix metalloprotease 1, Matrix metalloproteinase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase), Matrix metalloproteinase 3 preproprotein, Matrix metalloproteinase II, Matrix metalloproteinase-1, Matrix metalloproteinase-13, Matrix metalloproteinase-14, Matrix metalloproteinase-2, Matrix metalloproteinase-3, Matrix metalloproteinase-7, Membrane type 1 metalloprotease, Membrane-type matrix metalloproteinase 1, Membrane-type-1 matrix metalloproteinase, Neutrophil gelatinase, OTTHUMP00000045866, PEX, PUMP 1, Proteoglycanase, Pump-1 protease, SL-1, STMY, STMY1, Stromelisin 1, Stromelysin 1 progelatinase, Stromelysin-1, TBE-1, Transin-1, Type V collagenase, Uterine matrilysin, Uterine metalloproteinase, collagenase, fibroblast, collagenase, interstitial
- Chemical Structure
Lab
Chemical Structure - Batimastat (BB-94) (DMSO solution), Matrix metalloprotease (MMP) inhibitor (AB146619)
2D chemical structure image of ab146619, Batimastat (BB-94) (DMSO solution), Matrix metalloprotease (MMP) inhibitor
Product details
Properties and storage information
Shipped at conditions
Appropriate short-term storage conditions
Appropriate long-term storage conditions
Storage information
Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
Each MMP plays distinct roles in processes like cell proliferation migration differentiation angiogenesis and apoptosis. MMP2 and MMP9 for example degrade type IV collagen which is a major component of basement membranes. These enzymes sometimes form complexes in order to regulate their activities more precisely. CD23 though not an MMP acts as an IgE receptor and modulates immune responses adding another layer of complexity to their biological roles.
Pathways
MMPs integrate into essential cellular processes notably the MAPK and PI3K/AKT pathways. These pathways significantly influence cell survival growth and movement. MMP14 activates pro-MMP2 on the cell surface linking it to the proteolytic process. MMP9 can also interact with proteins such as TIMP-1 which inhibits MMP activity to maintain balance in ECM remodeling.
Publications (2)
Recent publications for all applications. Explore the full list and refine your search
The Journal of experimental medicine 217: PubMed32860705
2020
Applications
Unspecified application
Species
Unspecified reactive species
Nature immunology 15:973-81 PubMed25151489
2014
Applications
Unspecified application
Species
Unspecified reactive species
Product promise
Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.
For licensing inquiries, please contact partnerships@abcam.com