JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB141228

BAY 11-7082, IkappaBalpha kinase inhibitor

Be the first to review this product! Submit a review

|

(14 Publications)

MW 207.25 Da, Purity >99%. Achieve your results faster with highly validated, pure and trusted compounds.
1 Images
Chemical Structure - BAY 11-7082, IkappaBalpha kinase inhibitor (AB141228)
  • Chemical Structure

Lab

Chemical Structure - BAY 11-7082, IkappaBalpha kinase inhibitor (AB141228)

2D chemical structure image of ab141228, BAY 11-7082, IkappaBalpha kinase inhibitor

Key facts

CAS number

19542-67-7

Purity

>99%

Form

Solid

form

Molecular weight

207.25 Da

Molecular formula

C<sub>1</sub><sub>0</sub>H<sub>9</sub>NO<sub>2</sub>S

PubChem

5353431

Nature

Synthetic

Solubility

Soluble in ethanol to 50 mM

Soluble in DMSO to 100 mM

Biochemical name

(E)-3-Tosylacrylonitrile

Canonical smiles

CC1=CC=C(C=C1)S(=O)(=O)C=CC#N

Isomeric smiles

CC1=CC=C(C=C1)S(=O)(=O)/C=C/C#N

InChi

InChI=1S/C10H9NO2S/c1-9-3-5-10(6-4-9)14(12,13)8-2-7-11/h2-6,8H,1H3/b8-2+

InChiKey

DOEWDSDBFRHVAP-KRXBUXKQSA-N

IUPAC Name

(E)-3-(4-methylphenyl)sulfonylprop-2-enenitrile

style
left-column

Complementary Products

Biochemicals

AB145522

TPCA 1, IkappaB kinase inhibitor

Chemical Structure - TPCA 1, IkappaB kinase inhibitor (AB145522)

  • 0
  • 0
Secondary Antibodies

AB150077

Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488)

Immunocytochemistry/ Immunofluorescence - Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (AB150077)

  • 5
  • 20
Biochemicals

AB141453

Puromycin dihydrochloride, Protein biosynthesis inhibitor

Chemical Structure - Puromycin dihydrochloride, Protein biosynthesis inhibitor (AB141453)

  • 0
  • 0
Primary Antibodies

AB9485

Anti-GAPDH antibody - Loading Control

BOND RX™ Validated|Lab Essentials

Immunocytochemistry/ Immunofluorescence - Anti-GAPDH antibody - Loading Control (AB9485)

  • 5
  • 88
style
left-column
style
left-column

Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
Store in the dark|Store under desiccating conditions|This product is air and light sensitive and impurities can occur as a result of air oxidation or due to metabolism by microbes
style
left-column

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

TDP1 also known as tyrosyl-DNA phosphodiesterase 1 is an important enzyme in DNA repair. Its molecular mass is approximately 68 kDa. TDP1 breaks phosphodiester bonds between DNA and tyrosine residues on trapped topoisomerase I resolving Top1-DNA complexes. This enzyme locates itself mainly in the nucleus of cells due to its role in dealing with DNA-related injuries. TDP1 ALDH1A1 and ROR gamma show widespread expression found in various tissues but most notably in neurons and hepatic tissues.
Biological function summary

TDP1 and similar proteins are involved in safeguarding genetic integrity by repairing damaged DNA. TDP1's activity is independent but collaborates within multi-protein complexes to enhance DNA repair efficiency. ALDH1A1 or aldehyde dehydrogenase 1 family member A1 functions primarily in aldehyde metabolism and detoxification processes while playing a plausible role in stem cell differentiation. ROR gamma also known as RAR-related orphan receptor gamma influences gene expression regulating immune response and circadian rhythms.

Pathways

These proteins find themselves within key biological routes. TDP1 operates in the single-strand break repair pathway important for correcting errors following replication stress and it interacts with PARP1 which is essential for chromatin regulation during repair. ALDH1A1 is part of the retinoic acid pathway impacting cell differentiation and development while ROR gamma plays a significant role in the NF-kappa B signaling pathway especially influencing immune system functionality.

The malfunction or alteration of these proteins can trigger various conditions. TDP1 mutations relate to neurodegenerative disorders such as SCAN1 where an impaired repair pathway leads to neuronal cell death. ALDH1A1 is connected to cancer progression particularly in stem-like cells of certain tumors and alterations in this protein can affect tumor growth and chemoresistance. ROR gamma has ties to autoimmune diseases such as psoriasis and rheumatoid arthritis as it regulates Th17 cell differentiation and interleukin production.
style
left-column
style
left-column

Product protocols

style
left-column

Publications (14)

Recent publications for all applications. Explore the full list and refine your search

PLoS pathogens 20:e1012790 PubMed39700261

2024

Macrophage MST1 protects against schistosomiasis-induced liver fibrosis by promoting the PPARγ-CD36 pathway and suppressing NF-κB signaling.

Applications

Unspecified application

Species

Unspecified reactive species

Jianyang Li,Xinyuan Cai,Yan Yang,Yulin Mao,Lin Ding,Qian Xue,Xunhao Hu,Yan Huang,Cong Sui,Yuxia Zhang

Nature 617:827-834 PubMed37165186

2023

EDA2R-NIK signalling promotes muscle atrophy linked to cancer cachexia.

Applications

Unspecified application

Species

Unspecified reactive species

Sevval Nur Bilgic,Aylin Domaniku,Batu Toledo,Samet Agca,Bahar Z C Weber,Dilsad H Arabaci,Zeynep Ozornek,Pascale Lause,Jean-Paul Thissen,Audrey Loumaye,Serkan Kir

Alcoholism, clinical and experimental research 46:724-735 PubMed35338490

2022

Glial cell line-derived neurotrophic factor contributes to alcoholic-induced liver injury by regulating the NF-κB pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Xuling Liu,Guangyue Yang,Tiantian Sun,Le Tao,Dongxiao Shen,Wei Zhang,Jie Zhang,Dongying Xue,Bei Chen,Liu Wu,Cheng Liu,Wenting Ma

Science advances 7:eabj7912 PubMed34919438

2021

The developmental origins of heterodonty and acrodonty as revealed by reptile dentitions.

Applications

Unspecified application

Species

Unspecified reactive species

Lotta Salomies,Julia Eymann,Joni Ollonen,Imran Khan,Nicolas Di-Poï

Signal transduction and targeted therapy 6:398 PubMed34795206

2021

Fusobacterium nucleatum enhances the efficacy of PD-L1 blockade in colorectal cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Yaohui Gao,Dexi Bi,Ruting Xie,Man Li,Jing Guo,Hu Liu,Xianling Guo,Juemin Fang,Tingting Ding,Huiyuan Zhu,Yuan Cao,Meichun Xing,Jiayi Zheng,Qing Xu,Qian Xu,Qing Wei,Huanlong Qin

Hepatology (Baltimore, Md.) 74:1971-1993 PubMed33931882

2021

Treatment of Retinoblastoma 1-Intact Hepatocellular Carcinoma With Cyclin-Dependent Kinase 4/6 Inhibitor Combination Therapy.

Applications

Unspecified application

Species

Unspecified reactive species

Jindan Sheng,Susumu Kohno,Nobuhiro Okada,Nobuyuki Okahashi,Kana Teranishi,Fumio Matsuda,Hiroshi Shimizu,Paing Linn,Naoko Nagatani,Minako Yamamura,Kenichi Harada,Shin-Ichi Horike,Hiroshi Inoue,Seiji Yano,Sharad Kumar,Shunsuke Kitajima,Itsuki Ajioka,Chiaki Takahashi

Cancer research 81:4305-4318 PubMed34049975

2021

Apolipoprotein E Promotes Immune Suppression in Pancreatic Cancer through NF-κB-Mediated Production of CXCL1.

Applications

Unspecified application

Species

Unspecified reactive species

Samantha B Kemp,Eileen S Carpenter,Nina G Steele,Katelyn L Donahue,Zeribe C Nwosu,Amanda Pacheco,Ashley Velez-Delgado,Rosa E Menjivar,Fatima Lima,Stephanie The,Carlos E Espinoza,Kristee Brown,Daniel Long,Costas A Lyssiotis,Arvind Rao,Yaqing Zhang,Marina Pasca di Magliano,Howard C Crawford

Molecular medicine reports 21:2103-2112 PubMed32186758

2020

Angiotensin II induces RAW264.7 macrophage polarization to the M1‑type through the connexin 43/NF‑κB pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Lei Wu,Kai Chen,Jingjie Xiao,Junzhou Xin,Liang Zhang,Xinzhi Li,Li Li,Junqiang Si,Li Wang,Ketao Ma

International journal of molecular medicine 43:2507-2515 PubMed30942429

2019

Soluble receptor for advanced glycation end-products enhanced the production of IFN-γ through the NF-κB pathway in macrophages recruited by ischemia/reperfusion.

Applications

Unspecified application

Species

Unspecified reactive species

Xiuling Zhang,Xianxian Cao,Mengqiu Dang,Hongxia Wang,Buxing Chen,Fenghe Du,Huihua Li,Xiangjun Zeng,Caixia Guo

Experimental biology and medicine (Maywood, N.J.) 244:213-226 PubMed30869553

2019

Grape seed proanthocyanidin extract alleviates arsenic-induced lung damage through NF-κB signaling.

Applications

Unspecified application

Species

Unspecified reactive species

Yunhua Hu,Meng Wei,Qiang Niu,Rulin Ma,Yu Li,Xianhua Wang,Gangling Feng,Shugang Li,Lijuan Pang
View all publications
style
left-column
style
left-column
style
right-column

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com