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AB230368

BAY-299, TAF1 and BRD1 inhibitor

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(1 Publication)

MW 429.5 Da, Purity >98%. Potent and selective bromodomain inhibitor of TAF1 (IC50 = 8-13 nM) and BRD1 (IC50 = 6-67 nM). More than 30-fold selective versus BRD9 and ATAD2. More than 300-fold selective versus BRD4. Inhibits BRD1 (IC50 = 0.58 μM) and TAF1 (IC50 = 0.9 μM) binding to Histone H4 in cell-based assays; also inhibits BRD1 (IC50 = 0.83 μM) and TAF1 (IC50 = 1.4 μM) binding to Histone H3.3.
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Chemical Structure - BAY-299, TAF1 and BRD1 inhibitor (AB230368)
  • Chemical Structure

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Chemical Structure - BAY-299, TAF1 and BRD1 inhibitor (AB230368)

2D chemical structure image of ab230368, BAY-299, TAF1 and BRD1 inhibitor

Key facts

CAS number

2080306-23-4

Purity

>98%

Form

Solid

form

Molecular weight

429.5 Da

Molecular formula

C<sub>2</sub><sub>5</sub>H<sub>2</sub><sub>3</sub>N<sub>3</sub>O<sub>4</sub>

PubChem

122705990

Nature

Synthetic

Solubility

100 mM in DMSO

Biochemical name

6-(3-Oxidanylpropyl)-2-(1,3,6-Trimethyl-2-Oxidanylidene-Benzimidazol-5-Yl)benzo[de]isoquinoline-1,3-Dione

Biological description

Potent and selective bromodomain inhibitor of TAF1 (IC50 = 8-13 nM) and BRD1 (IC50 = 6-67 nM). More than 30-fold selective versus BRD9 and ATAD2. More than 300-fold selective versus BRD4. Inhibits BRD1 (IC50 = 0.58 μM) and TAF1 (IC50 = 0.9 μM) binding to Histone H4 in cell-based assays; also inhibits BRD1 (IC50 = 0.83 μM) and TAF1 (IC50 = 1.4 μM) binding to Histone H3.3.

Canonical smiles

CC1=CC2=C(C=C1N3C(=O)C4=C5C(=C(C=C4)CCCO)C=CC=C5C3=O)N(C(=O)N2C)C

InChi

InChI=1S/C25H23N3O4/c1-14-12-20-21(27(3)25(32)26(20)2)13-19(14)28-23(30)17-8-4-7-16-15(6-5-11-29)9-10-18(22(16)17)24(28)31/h4,7-10,12-13,29H,5-6,11H2,1-3H3

InChiKey

OFWWWKWUCDUISA-UHFFFAOYSA-N

IUPAC Name

6-(3-hydroxypropyl)-2-(1,3,6-trimethyl-2-oxobenzimidazol-5-yl)benzo[de]isoquinoline-1,3-dione

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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
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Product protocols

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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Biochemistry 61:1774-1789 PubMed35976792

2022

Molecular Insights into the Recognition of Acetylated Histone Modifications by the BRPF2 Bromodomain.

Applications

Unspecified application

Species

Unspecified reactive species

Soumen Barman,Anirban Roy,Jyotirmayee Padhan,Babu Sudhamalla
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