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AB144521

BAY 41-2272, Soluble guanylyl cyclase (sGC) activator

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MW 360.4 Da, Purity >98%. Soluble guanylyl cyclase (sGC) activator. Induces cGMP synthesis independent of NO. Potent platelet aggregation inhibitor (IC50 = 36 nM). Shows antivasoconstrictive effects (IC50 = 0.30 μM). Induces phagocytosis. Shows vasodilatory effects in vivo. .

View Alternative Names

IMD42, MGC129539, NR1F3, Nuclear receptor ROR-gamma, Nuclear receptor RZR-gamma, Nuclear receptor subfamily 1 group F member 3, RAR related orphan nuclear receptor variant 2, RAR related orphan receptor C, isoform a, RAR related orphan receptor gamma, RAR-related orphan receptor C, RORG_HUMAN, RZR GAMMA, RZRG, Retinoic acid binding receptor gamma, Retinoid-related orphan receptor-gamma, Rorc, TOR

Key facts

CAS number

256376-24-6

Purity

>98%

Form

Solid

form

Molecular weight

360.4 Da

Molecular formula

C<sub>2</sub><sub>0</sub>H<sub>1</sub><sub>7</sub>FN<sub>6</sub>

PubChem

9798973

Nature

Synthetic

Solubility

Soluble in DMSO to 100 mM

Biochemical name

Bay 41-2272

Biological description

Soluble guanylyl cyclase (sGC) activator. Induces cGMP synthesis independent of NO. Potent platelet aggregation inhibitor (IC50 = 36 nM). Shows antivasoconstrictive effects (IC50 = 0.30 μM). Induces phagocytosis. Shows vasodilatory effects in vivo.

Canonical smiles

C1CC1C2=CN=C(N=C2N)C3=NN(C4=C3C=CC=N4)CC5=CC=CC=C5F

InChi

InChI=1S/C20H17FN6/c21-16-6-2-1-4-13(16)11-27-20-14(5-3-9-23-20)17(26-27)19-24-10-15(12-7-8-12)18(22)25-19/h1-6,9-10,12H,7-8,11H2,(H2,22,24,25)

InChiKey

ATOAHNRJAXSBOR-UHFFFAOYSA-N

IUPAC Name

5-cyclopropyl-2-[1-[(2-fluorophenyl)methyl]pyrazolo[3,4-b]pyridin-3-yl]pyrimidin-4-amine

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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
+4°C
Storage information
Store under desiccating conditions|The product can be stored for up to 12 months
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Product protocols

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