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AB141323

BD 1063 dihydrochloride, sigma-1 antagonist

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(1 Publication)

MW 346.1 Da, Purity >99%. Potent selective σ1 receptor antagonist (Ki values are 9 and 449 nM at σ1 and σ2 receptors, respectively). Shown to prevent hyperlocomotion, active in vivo.
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Chemical Structure - BD 1063 dihydrochloride, sigma-1 antagonist (AB141323)
  • Chemical Structure

Lab

Chemical Structure - BD 1063 dihydrochloride, sigma-1 antagonist (AB141323)

2D chemical structure image of ab141323, BD 1063 dihydrochloride, sigma-1 antagonist

Key facts

CAS number

150208-28-9

Purity

>99%

Form

Solid

form

Molecular weight

346.1 Da

Molecular formula

C<sub>1</sub><sub>3</sub>H<sub>2</sub><sub>0</sub>Cl<sub>4</sub>N<sub>2</sub>

PubChem

11617161

Nature

Synthetic

Solubility

Soluble in water to 100 mM

Biochemical name

BD 1063 Dihydrochloride

Biological description

Potent selective σ1 receptor antagonist (Ki values are 9 and 449 nM at σ1 and σ2 receptors, respectively). Shown to prevent hyperlocomotion, active in vivo.

Canonical smiles

CN1CCN(CC1)CCC2=CC(=C(C=C2)Cl)Cl.Cl.Cl

InChi

InChI=1S/C13H18Cl2N2.2ClH/c1-16-6-8-17(9-7-16)5-4-11-2-3-12(14)13(15)10-11;;/h2-3,10H,4-9H2,1H3;2*1H

InChiKey

NXFDBTLQOARIMH-UHFFFAOYSA-N

IUPAC Name

1-[2-(3,4-dichlorophenyl)ethyl]-4-methylpiperazine;dihydrochloride

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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
Ambient
Appropriate long-term storage conditions
Ambient
Storage information
The product can be stored for up to 12 months
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Product protocols

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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Cell calcium 58:196-207 PubMed26077147

2015

Mechanisms of activation of nucleus accumbens neurons by cocaine via sigma-1 receptor-inositol 1,4,5-trisphosphate-transient receptor potential canonical channel pathways.

Applications

Unspecified application

Species

Unspecified reactive species

Jeffrey L Barr,Elena Deliu,G Cristina Brailoiu,Pingwei Zhao,Guang Yan,Mary E Abood,Ellen M Unterwald,Eugen Brailoiu
View all publications
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