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AB120301

beta-Amyloid Peptide (1-42) (human)

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(1 Review)

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(52 Publications )

Beta Amyloid (1-42) Peptide (Human)(CAS:107761-42-2)(ab120301) is the predominant amyloid β-peptide found in plaques associated with Alzheimer's disease (AD). Molecular weight (MW) 4514.

- Available in different sizes to fit your experimental needs
- Proven performance: cited in over 50 publications
1 Images
Chemical Structure - beta-Amyloid Peptide (1-42) (human) (AB120301)
  • Chemical Structure

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Chemical Structure - beta-Amyloid Peptide (1-42) (human) (AB120301)

2D chemical structure image of ab120301, beta-Amyloid Peptide (1-42) (human)

Key facts

CAS number

107761-42-2

Purity

>95%

Form

Solid

form

Formulation

Constituents: 95% Amyloid beta (1-42) (human)

Molecular weight

4514 Da

Molecular formula

C<sub>2</sub><sub>0</sub><sub>3</sub>H<sub>3</sub><sub>1</sub><sub>1</sub>N<sub>5</sub><sub>5</sub>O<sub>6</sub><sub>0</sub>S

PubChem

57339251

Nature

Synthetic

Solubility

Solubility is batch-dependent. Please refer to the Protocol Booklet and the batch-specific CoA for more information.

Biochemical name

Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val-Ile-Ala

Canonical smiles

CCC(C)C(C(=O)NC(C(C)CC)C(=O)NCC(=O)NC(CC(C)C)C(=O)NC(CCSC)C(=O)NC(C(C)C)C(=O)NCC(=O)NCC(=O)NC(C(C)C)C(=O)NC(C(C)C)C(=O)NC(C(C)CC)C(=O)NC(C)C(=O)O)NC(=O)C(C)NC(=O)CNC(=O)C(CCCCN)NC(=O)C(CC(=O)N)NC(=O)C(CO)NC(=O)CNC(=O)C(C(C)C)NC(=O)C(CC(=O)O)NC(=O)C(CCC(=O

Isomeric smiles

CC[C@H](C)[C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)NCC(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(=O)O)NC(=O)[C@H](C)NC(=O)CNC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(=O)N)NC(=O)[C@H](CO)NC(=O)CNC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](C)NC(=O)[C@H](CC1=CC=CC=C1)NC(=O)[C@H](CC2=CC=CC=C2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](CC3=CNC=N3)NC(=O)[C@H](CC4=CNC=N4)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC5=CC=C(C=C5)O)NC(=O)CNC(=O)[C@H](CO)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC6=CNC=N6)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC7=CC=CC=C7)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](C)NC(=O)[C@H](CC(=O)O)N

InChi

InChI=1S/C203H311N55O60S/c1-28-106(20)164(195(310)220-91-149(267)228-130(71-98(4)5)181(296)238-129(66-70-319-27)179(294)251-158(100(8)9)193(308)218-87-146(264)215-88-151(269)250-160(102(12)13)198(313)255-163(105(18)19)199(314)258-165(107(21)29-2)200(315)227-112(26)202(317)318)257-201(316)166(108(22)30-3)256-169(284)109(23)224-147(265)89-216-171(286)122(51-40-42-67-204)233-188(303)139(81-145(208)263)244-192(307)143(94-260)230-150(268)92-219-194(309)159(101(10)11)252-191(306)141(83-157(280)281)245-177(292)127(60-64-153(272)273)232-168(283)111(25)226-180(295)133(73-113-45-34-31-35-46-113)241-184(299)135(75-115-49-38-33-39-50-115)247-196(311)162(104(16)17)254-190(305)131(72-99(6)7)239-173(288)123(52-41-43-68-205)234-175(290)125(58-62-144(207)262)236-185(300)136(77-117-84-211-95-221-117)243-187(302)138(79-119-86-213-97-223-119)248-197(312)161(103(14)15)253-178(293)128(61-65-154(274)275)237-182(297)132(76-116-54-56-120(261)57-55-116)229-148(266)90-217-172(287)142(93-259)249-189(304)140(82-156(278)279)246-186(301)137(78-118-85-212-96-222-118)242-174(289)124(53-44-69-214-203(209)210)235-183(298)134(74-114-47-36-32-37-48-114)240-176(291)126(59-63-152(270)271)231-167(282)110(24)225-170(285)121(206)80-155(276)277/h31-39,45-50,54-57,84-86,95-112,121-143,158-166,259-261H,28-30,40-44,51-53,58-83,87-94,204-206H2,1-27H3,(H2,207,262)(H2,208,263)(H,211,221)(H,212,222)(H,213,223)(H,215,264)(H,216,286)(H,217,287)(H,218,308)(H,219,309)(H,220,310)(H,224,265)(H,225,285)(H,226,295)(H,227,315)(H,228,267)(H,229,266)(H,230,268)(H,231,282)(H,232,283)(H,233,303)(H,234,290)(H,235,298)(H,236,300)(H,237,297)(H,238,296)(H,239,288)(H,240,291)(H,241,299)(H,242,289)(H,243,302)(H,244,307)(H,245,292)(H,246,301)(H,247,311)(H,248,312)(H,249,304)(H,250,269)(H,251,294)(H,252,306)(H,253,293)(H,254,305)(H,255,313)(H,256,284)(H,257,316)(H,258,314)(H,270,271)(H,272,273)(H,274,275)(H,276,277)(H,278,279)(H,280,281)(H,317,318)(H4,209,210,214)/t106-,107-,108-,109-,110-,111-,112-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,138-,139-,140-,141-,142-,143-,158-,159-,160-,161-,162-,163-,164-,165-,166-/m0/s1

InChiKey

DZHSAHHDTRWUTF-SIQRNXPUSA-N

IUPAC Name

(4S)-5-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[2-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-5-amino-1-[[(2S)-6-amino-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[2-[[(2S)-1-[[(2S)-4-amino-1-[[(2S)-6-amino-1-[[2-[[(2S)-1-[[(2S,3S)-1-[[(2S,3S)-1-[[2-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[2-[[2-[[(2S)-1-[[(2S)-1-[[(2S,3S)-1-[[(1S)-1-carboxyethyl]amino]-3-methyl-1-oxopentan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-2-oxoethyl]amino]-2-oxoethyl]amino]-3-methyl-1-oxobutan-2-yl]amino]-4-methylsulfanyl-1-oxobutan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-2-oxoethyl]amino]-3-methyl-1-oxopentan-2-yl]amino]-3-methyl-1-oxopentan-2-yl]amino]-1-oxopropan-2-yl]amino]-2-oxoethyl]amino]-1-oxohexan-2-yl]amino]-1,4-dioxobutan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-2-oxoethyl]amino]-3-methyl-1-oxobutan-2-yl]amino]-3-carboxy-1-oxopropan-2-yl]amino]-4-carboxy-1-oxobutan-2-yl]amino]-1-oxopropan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-1-oxohexan-2-yl]amino]-1,5-dioxopentan-2-yl]amino]-3-(1H-imidazol-4-yl)-1-oxopropan-2-yl]amino]-3-(1H-imidazol-4-yl)-1-oxopropan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-4-carboxy-1-oxobutan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-2-oxoethyl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-3-carboxy-1-oxopropan-2-yl]amino]-3-(1H-imidazol-4-yl)-1-oxopropan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-4-[[(2S)-2-[[(2S)-2-amino-3-carboxypropanoyl]amino]propanoyl]amino]-5-oxopentanoic acid

Reconstitution

For reconstitution, amyloid ß (1-42) human peptide should be dissolved according to this method: Add a small amount of 1% NH4OH directly to the lyophilized solid (50-100 µl should be sufficient for 1mg of peptide). Dilute to a concentration of 1mg/ml or less with your buffer. Vortex gently to mix (less than 1 minute). The peptide cannot be stored long term in 1% NH4OH, therefore it is important to immediately dilute the NH4OH/peptide solution with PBS or other buffer to a concentration of 1 mg/ml.

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Complementary Products

Biochemicals

AB120479

beta-Amyloid Peptide (1-40) (human)

Chemical Structure - beta-Amyloid Peptide (1-40) (human) (AB120479)

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Secondary Antibodies

AB150077

Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488)

Immunocytochemistry/ Immunofluorescence - Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (AB150077)

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Biochemicals

AB120481

beta-Amyloid Peptide (42-1) (human), Inactive control

Chemical Structure - beta-Amyloid Peptide (42-1) (human), Inactive control (AB120481)

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Secondary Antibodies

AB205718

Goat Anti-Rabbit IgG H&L (HRP)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Goat Anti-Rabbit IgG H&L (HRP) (AB205718)

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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
Store under desiccating conditions|The product can be stored for up to 12 months
Handling instructions

This product is supplied in one (or more) pack size which is freeze dried. Therefore the contents may not be readily visible, as they can coat the bottom or walls of the vial. Please refer to our product support page for more details on handling.

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Need more advice on solubility, usage and handling? Please visit our product support page for more details.

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Solvents listed may be unsuitable for use in biological experiments. These solvents are intended to enable solubilisation and mixing of components. We recommend that biologically unsuitable solvents are removed prior to solubilisation in experimental media.

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Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one week. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

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Product protocols

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Publications (52)

Recent publications for all applications. Explore the full listand refine your search

Molecules (Basel, Switzerland) 30: PubMed40430359

2025

Exploring the Neuroprotective Properties of Celery ( Linn) Extract Against Amyloid-Beta Toxicity and Enzymes Associated with Alzheimer's Disease.

Applications

Unspecified application

Species

Unspecified reactive species

Layla Mohamud Dirie,Tahire Yurdakul,Sevim Isik,Shirin Tarbiat

Biology of sex differences 16:36 PubMed40414897

2025

Mapping the hippocampal spatial proteomic signature in male and female mice of an early Alzheimer's disease model.

Applications

Unspecified application

Species

Unspecified reactive species

Ana Contreras,Raquel Jiménez-Herrera,Souhail Djebari,Juan D Navarro-López,Lydia Jiménez-Díaz

MedComm 6:e70156 PubMed40276647

2025

DEAD-Box Helicase 6 Blockade in Brain-Derived Aβ Oligomers From Alzheimer's Disease Patients Attenuates Neurotoxicity.

Applications

Unspecified application

Species

Unspecified reactive species

Xiaoxu Wang,Lu Dai,Na Wu,Donghui Wu,Xinyuan Wang,Xia Meng,Qilei Zhang,Jing Lu,Xiaoxin Yan,Jing Zhang,Baian Chen

Alzheimer's & dementia : the journal of the Alzheimer's Association 21:e70086 PubMed40237235

2025

Lecanemab preferentially binds to smaller aggregates present at early Alzheimer's disease.

Applications

Unspecified application

Species

Unspecified reactive species

Emre Fertan,Jeff Y L Lam,Giulia Albertini,Maarten Dewilde,Yunzhao Wu,Oluwatomi E S Akingbade,Dorothea Böken,Elizabeth A English,Bart De Strooper,David Klenerman

EClinicalMedicine 81:103142 PubMed40115175

2025

Development and validation of machine learning models with blood-based digital biomarkers for Alzheimer's disease diagnosis: a multicohort diagnostic study.

Applications

Unspecified application

Species

Unspecified reactive species

Bin Jiao,Ziyu Ouyang,Xuewen Xiao,Cong Zhang,Tianyan Xu,Qijie Yang,Yuan Zhu,Yiliang Liu,Xixi Liu,Yafang Zhou,Xinxin Liao,Shilin Luo,Beisha Tang,Zhigang Li,Lu Shen

Journal of microbiology and biotechnology 35:e2412026 PubMed40016145

2025

Amelioration of Astrocytic Dysfunction via AQP4/LRP1 Pathway by and Tricin in C6 Cells Exposed to Amyloid β and High-Dose Insulin and in Mice Treated with Scopolamine.

Applications

Unspecified application

Species

Unspecified reactive species

Seun-Ah Yang,Se-Ho Park,Eun-Hye Kim,Won-Bin Bae,Kwang-Hwan Jhee

Nutrients 17: PubMed39796582

2025

DAG-MAG-ΒHB: A Novel Ketone Diester Modulates NLRP3 Inflammasome Activation in Microglial Cells in Response to Beta-Amyloid and Low Glucose AD-like Conditions.

Applications

Unspecified application

Species

Unspecified reactive species

Valentina Gentili,Giovanna Schiuma,Latha Nagamani Dilliraj,Silvia Beltrami,Sabrina Rizzo,Djidjell Lara,Pier Paolo Giovannini,Matteo Marti,Daria Bortolotti,Claudio Trapella,Marco Narducci,Roberta Rizzo

Neurochemical research 50:50 PubMed39644364

2024

Neuroprotective Potential of Aminonaphthoquinone Derivatives Against Amyloid Beta-Induced Neuronal Cell Death Through Modulation of SIRT1 and BACE1.

Applications

Unspecified application

Species

Unspecified reactive species

Setthawut Apiraksattayakul,Ratchanok Pingaew,Veda Prachayasittikul,Waralee Ruankham,Tanawut Tantimongcolwat,Virapong Prachayasittikul,Supaluk Prachayasittikul,Kamonrat Phopin

Nutrients 16: PubMed39519499

2024

In Vitro Assessment of the Neuroprotective Effects of Pomegranate ( L.) Polyphenols Against Tau Phosphorylation, Neuroinflammation, and Oxidative Stress.

Applications

Unspecified application

Species

Unspecified reactive species

Mehdi Alami,Kaoutar Boumezough,Echarki Zerif,Nada Zoubdane,Abdelouahed Khalil,Ton Bunt,Benoit Laurent,Jacek M Witkowski,Charles Ramassamy,Samira Boulbaroud,Tamas Fulop,Hicham Berrougui

Scientific reports 14:26021 PubMed39472479

2024

Reverse engineering of feedforward cortical-Hippocampal microcircuits for modelling neural network function and dysfunction.

Applications

Unspecified application

Species

Unspecified reactive species

Katrine Sjaastad Hanssen,Nicolai Winter-Hjelm,Salome Nora Niethammer,Asgeir Kobro-Flatmoen,Menno P Witter,Axel Sandvig,Ioanna Sandvig
View all publications
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