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AB145171

beta-Elemene, Anticancer agent

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MW 204.35 Da. Anticancer agent. Induces G2M cell cycle arrest and apoptosis. Induces caspase-3, -7 and -9 activities. Decreases Bcl-2 expression. Induces mitochondrial release of cytochrome c. Inhibits microtubule polymerization. Downregulates uPA, uPAR, MMP-2, and MMP-9 expression. Shows antiproliferative effects. Shows antitumor effects in vivo. .
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Chemical Structure - beta-Elemene, Anticancer agent (AB145171)
  • Chemical Structure

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Chemical Structure - beta-Elemene, Anticancer agent (AB145171)

2D chemical structure image of ab145171, beta-Elemene, Anticancer agent

Key facts

CAS number

515-13-9

Source

Curcuma aromatica

Molecular weight

204.35 Da

Molecular formula

C<sub>1</sub><sub>5</sub>H<sub>2</sub><sub>4</sub>

PubChem

10583

Nature

Native

Biochemical name

Cyclohexane, 1-ethenyl-1-methyl-2,4-bis(1-methylethenyl)-, (1R,2R,4S)-rel-

Biological description

Anticancer agent. Induces G2M cell cycle arrest and apoptosis. Induces caspase-3, -7 and -9 activities. Decreases Bcl-2 expression. Induces mitochondrial release of cytochrome c. Inhibits microtubule polymerization. Downregulates uPA, uPAR, MMP-2, and MMP-9 expression. Shows antiproliferative effects. Shows antitumor effects in vivo.

Canonical smiles

CC(=C)C1CCC(C(C1)C(=C)C)(C)C=C

InChi

InChI=1S/C15H24/c1-7-15(6)9-8-13(11(2)3)10-14(15)12(4)5/h7,13-14H,1-2,4,8-10H2,3,5-6H3

InChiKey

OPFTUNCRGUEPRZ-UHFFFAOYSA-N

IUPAC Name

1-ethenyl-1-methyl-2,4-bis(prop-1-en-2-yl)cyclohexane

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Complementary Products

Biochemicals

AB144290

Latrunculin A (LAT-A), Actin polymerization inhibitor

Chemical Structure - Latrunculin A (LAT-A), Actin polymerization inhibitor (AB144290)

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Biochemicals

AB142087

Batimastat (BB-94), Matrix metalloprotease (MMP) inhibitor

Chemical Structure - Batimastat (BB-94), Matrix metalloprotease (MMP) inhibitor (AB142087)

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Biochemicals

AB141475

Vinblastine sulfate, Microtubule dynamics inhibitor

Chemical Structure - Vinblastine sulfate, Microtubule dynamics inhibitor (AB141475)

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Biochemicals

AB144366

Swinholide A, F-actin inhibitor

Chemical Structure - Swinholide A, F-actin inhibitor (AB144366)

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Product details

β-Elemene exists as a liquid in its pure form at room temperature. There is no concentration because product itself is pure β-Elemene. Its appearance is clear and colorless liquid.
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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
+4°C
Storage information
The product can be stored for up to 12 months
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Product protocols

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