MW 244.28 Da, Purity >98%. Topoisomerase I inhibitor. Inhibits topoisomerase I induced DNA cleavage. Induces apoptosis via a p53 independent mechanism. Shows antitumor, antiviral, antibacterial, antifungal and wound healing activities.
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- Neurochemical research 48:3177-31892023G6PDi-1 is a Potent Inhibitor of G6PDH and of Pentose Phosphate pathway-dependent Metabolic Processes in Cultured Primary Astrocytes.Applications:Unspecified applicationReactive species:Unspecified reactive speciesPatrick Watermann,Christian Arend,Ralf DringenPubMed 37394677
- Neurochemical research 48:2148-21602023β-lapachone-mediated WST1 Reduction as Indicator for the Cytosolic Redox Metabolism of Cultured Primary Astrocytes.Applications:Unspecified applicationReactive species:Unspecified reactive speciesPatrick Watermann,Ralf DringenPubMed 36811754
- Neurochemical research 45:2442-24552020β-Lapachone Induces Acute Oxidative Stress in Rat Primary Astrocyte Cultures that is Terminated by the NQO1-Inhibitor Dicoumarol.Applications:Unspecified applicationReactive species:Unspecified reactive speciesJohann Steinmeier et. al.PubMed 32789798
- International immunopharmacology 81:1063002020β-Lapachone attenuates cognitive impairment and neuroinflammation in beta-amyloid induced mouse model of Alzheimer's disease.Applications:Unspecified applicationReactive species:Unspecified reactive speciesNarmin Mokarizadeh et. al.PubMed 32070922
Key facts
- CAS number
- 132820-30-5
- Purity
- > 98%
- Form
- Solid
- Molecular weight
- 244.28 Da
- Molecular formula
- C15H16O3
- PubChem identifier
- 497540
- Nature
- Synthetic
Recommended products
MW 244.28 Da, Purity >98%. Topoisomerase I inhibitor. Inhibits topoisomerase I induced DNA cleavage. Induces apoptosis via a p53 independent mechanism. Shows antitumor, antiviral, antibacterial, antifungal and wound healing activities.
Key facts
- CAS number
- 132820-30-5
- Purity
- > 98%
- Form
- Solid
- Molecular weight
- 244.28 Da
- Molecular formula
- C15H16O3
- PubChem identifier
- 497540
- Nature
- Synthetic
- Solubility
Soluble in ethanol to 50 mM.
Soluble in DMSO to 100 mM.
- Biochemical name
- 2,2-Dimethyl-3,4,4a,10b-tetrahydrobenzo[h]chromene-5,6-dione
- Biological description
Topoisomerase I inhibitor. Inhibits topoisomerase I induced DNA cleavage. Induces apoptosis via a p53 independent mechanism. Shows antitumor, antiviral, antibacterial, antifungal and wound healing activities.
- Canonical SMILES
- CC1(CCC2C(O1)C3=CC=CC=C3C(=O)C2=O)C
- InChI
- InChI=1S/C15H16O3/c1-15(2)8-7-11-13(17)12(16)9-5-3-4-6-10(9)14(11)18-15/h3-6,11,14H,7-8H2,1-2H3
- InChIKey
- FGGFBHJNRSCDBK-UHFFFAOYSA-N
- IUPAC name
- 2,2-dimethyl-3,4,4a,10b-tetrahydrobenzo[h]chromene-5,6-dione
Storage
- Shipped at conditions
- Ambient - Can Ship with Ice
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- +4°C
- Storage information
- The product can be stored for up to 12 months
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2 product images
Chemical Structure - beta-Lapachone, Topoisomerase I inhibitor (ab141097)
2D chemical structure of ab141097, beta-Lapachone, Topoisomerase I inhibitor
Functional Studies - beta-Lapachone, Topoisomerase I inhibitor (ab141097)
ab18209 staining p21 in serum starved PC-3 cells treated with ß-lapachone (ab141097), by ICC/IF. Increase of p21 nuclear expression correlates with increased concentration of ß-lapachone, as described in literature.
The cells were incubated at 37°C for 6 hours in media containing different concentrations of ab141097 (ß-lapachone) in DMSO, fixed with 100% methanol for 5 minutes at -20°C and blocked with PBS containing 10% goat serum, 0.3 M glycine, 1% BSA and 0.1% tween for 2h at room temperature. Staining of the treated cells with ab18209 (5 µg/ml) was performed overnight at 4°C in PBS containing 1% BSA and 0.1% tween. A DyLight 488 anti-rabbit polyclonal antibody (Goat Anti-Rabbit IgG H&L (DyLight® 488) preadsorbed ab96899) at 1/250 dilution was used as the secondary antibody. Nuclei were counterstained with DAPI and are shown in blue.
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