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AB141097

beta-Lapachone, Topoisomerase I inhibitor

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(5 Publications)

MW 244.28 Da, Purity >98%. Topoisomerase I inhibitor. Inhibits topoisomerase I induced DNA cleavage. Induces apoptosis via a p53 independent mechanism. Shows antitumor, antiviral, antibacterial, antifungal and wound healing activities.
2 Images
Functional Studies - beta-Lapachone, Topoisomerase I inhibitor (AB141097)
  • FuncS

Unknown

Functional Studies - beta-Lapachone, Topoisomerase I inhibitor (AB141097)

ab18209 staining p21 in serum starved PC-3 cells treated with ß-lapachone (ab141097), by ICC/IF. Increase of p21 nuclear expression correlates with increased concentration of ß-lapachone, as described in literature.
The cells were incubated at 37°C for 6 hours in media containing different concentrations of ab141097 (ß-lapachone) in DMSO, fixed with 100% methanol for 5 minutes at -20°C and blocked with PBS containing 10% goat serum, 0.3 M glycine, 1% BSA and 0.1% tween for 2h at room temperature. Staining of the treated cells with ab18209 (5 µg/ml) was performed overnight at 4°C in PBS containing 1% BSA and 0.1% tween. A DyLight® 488 anti-rabbit polyclonal antibody (ab96899) at 1/250 dilution was used as the secondary antibody. Nuclei were counterstained with DAPI and are shown in blue.

Chemical Structure - beta-Lapachone, Topoisomerase I inhibitor (AB141097)
  • Chemical Structure

Unknown

Chemical Structure - beta-Lapachone, Topoisomerase I inhibitor (AB141097)

2D chemical structure of ab141097, beta-Lapachone, Topoisomerase I inhibitor

Key facts

CAS number

132820-30-5

Purity

>98%

Form

Solid

form

Molecular weight

244.28 Da

Molecular formula

C<sub>1</sub><sub>5</sub>H<sub>1</sub><sub>6</sub>O<sub>3</sub>

PubChem

497540

Nature

Synthetic

Solubility

Soluble in ethanol to 50 mM

Soluble in DMSO to 100 mM

Biochemical name

2,2-Dimethyl-3,4,4a,10b-tetrahydrobenzo[h]chromene-5,6-dione

Biological description

Topoisomerase I inhibitor. Inhibits topoisomerase I induced DNA cleavage. Induces apoptosis via a p53 independent mechanism. Shows antitumor, antiviral, antibacterial, antifungal and wound healing activities.

Canonical smiles

CC1(CCC2C(O1)C3=CC=CC=C3C(=O)C2=O)C

InChi

InChI=1S/C15H16O3/c1-15(2)8-7-11-13(17)12(16)9-5-3-4-6-10(9)14(11)18-15/h3-6,11,14H,7-8H2,1-2H3

InChiKey

FGGFBHJNRSCDBK-UHFFFAOYSA-N

IUPAC Name

2,2-dimethyl-3,4,4a,10b-tetrahydrobenzo[h]chromene-5,6-dione

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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
+4°C
Storage information
The product can be stored for up to 12 months
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Product protocols

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Publications (5)

Recent publications for all applications. Explore the full list and refine your search

Neurochemical research 50:24 PubMed39562371

2024

Differential Effects of Itaconate and its Esters on the Glutathione and Glucose Metabolism of Cultured Primary Rat Astrocytes.

Applications

Unspecified application

Species

Unspecified reactive species

Patrick Watermann,Gurleen K Kalsi,Ralf Dringen,Christian Arend

Neurochemical research 48:3177-3189 PubMed37394677

2023

G6PDi-1 is a Potent Inhibitor of G6PDH and of Pentose Phosphate pathway-dependent Metabolic Processes in Cultured Primary Astrocytes.

Applications

Unspecified application

Species

Unspecified reactive species

Patrick Watermann,Christian Arend,Ralf Dringen

Neurochemical research 48:2148-2160 PubMed36811754

2023

β-lapachone-mediated WST1 Reduction as Indicator for the Cytosolic Redox Metabolism of Cultured Primary Astrocytes.

Applications

Unspecified application

Species

Unspecified reactive species

Patrick Watermann,Ralf Dringen

Neurochemical research 45:2442-2455 PubMed32789798

2020

β-Lapachone Induces Acute Oxidative Stress in Rat Primary Astrocyte Cultures that is Terminated by the NQO1-Inhibitor Dicoumarol.

Applications

Unspecified application

Species

Unspecified reactive species

Johann Steinmeier,Sophie Kube,Gabriele Karger,Eric Ehrke,Ralf Dringen

International immunopharmacology 81:106300 PubMed32070922

2020

β-Lapachone attenuates cognitive impairment and neuroinflammation in beta-amyloid induced mouse model of Alzheimer's disease.

Applications

Unspecified application

Species

Unspecified reactive species

Narmin Mokarizadeh,Pouran Karimi,Marjan Erfani,Saeed Sadigh-Eteghad,Nazila Fathi Maroufi,Nadereh Rashtchizadeh
View all publications
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