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MW 334.22 Da, Purity >98%. Product of the NAMPT reaction and a key intermediate in the biosynthesis of nicotinamide adenine dinucleotide (NAD+). Ameliorates glucose intolerance by restoring NAD+ levels in high-fat diet (HFD)-induced T2D mice. Enhances hepatic insulin sensitivity and restores gene expression related to oxidative stress, inflammatory response, and circadian rhythm, partly through SIRT1 activation.

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Images

Chemical Structure - beta-Nicotinamide mononucleotide, Key NAD+ intermediate (AB223879), expandable thumbnail

Key facts

CAS number
1094-61-7
Purity
> 98%
Form
Solid
Molecular weight
334.22 Da
Molecular formula
C11H15N2O8P
PubChem identifier
14180
Nature
Synthetic

Target data

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MW 334.22 Da, Purity >98%. Product of the NAMPT reaction and a key intermediate in the biosynthesis of nicotinamide adenine dinucleotide (NAD+). Ameliorates glucose intolerance by restoring NAD+ levels in high-fat diet (HFD)-induced T2D mice. Enhances hepatic insulin sensitivity and restores gene expression related to oxidative stress, inflammatory response, and circadian rhythm, partly through SIRT1 activation.

Key facts

Purity
> 98%
PubChem identifier
14180
Solubility

Soluble in water to 100 mM.

Biochemical name
Nicotinamide mononucleotide
Biological description

Product of the NAMPT reaction and a key intermediate in the biosynthesis of nicotinamide adenine dinucleotide (NAD+). Ameliorates glucose intolerance by restoring NAD+ levels in high-fat diet (HFD)-induced T2D mice. Enhances hepatic insulin sensitivity and restores gene expression related to oxidative stress, inflammatory response, and circadian rhythm, partly through SIRT1 activation.

Canonical SMILES
C1=CC(=C[N+](=C1)C2C(C(C(O2)COP(=O)(O)[O-])O)O)C(=O)N
Isomeric SMILES
C1=CC(=C[N+](=C1)[C@H]2[C@@H]([C@@H]([C@H](O2)COP(=O)(O)[O-])O)O)C(=O)N
InChI
InChI=1S/C11H15N2O8P/c12-10(16)6-2-1-3-13(4-6)11-9(15)8(14)7(21-11)5-20-22(17,18)19/h1-4,7-9,11,14-15H,5H2,(H3-,12,16,17,18,19)/t7-,8-,9-,11-/m1/s1
InChIKey
DAYLJWODMCOQEW-TURQNECASA-N
IUPAC name
[(2R,3S,4R,5R)-5-(3-carbamoylpyridin-1-ium-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl hydrogen phosphate

Storage

Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
Store under desiccating conditions

Notes

This product is manufactured by BioVision, an Abcam company and was previously called 2733 β-Nicotinamide mononucleotide. 2733-250 is the same size as the 250 mg size of ab223879.

Protect from air and moisture.

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1 product image

  • Chemical Structure - beta-Nicotinamide mononucleotide, Key NAD+ intermediate (ab223879), expandable thumbnail

    Chemical Structure - beta-Nicotinamide mononucleotide, Key NAD+ intermediate (ab223879)

    2D chemical structure image of ab223879, beta-Nicotinamide mononucleotide, Key NAD+ intermediate

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Product protocols

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