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AB223879

beta-Nicotinamide mononucleotide, Key NAD+ intermediate

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MW 334.22 Da, Purity >98%. Product of the NAMPT reaction and a key intermediate in the biosynthesis of nicotinamide adenine dinucleotide (NAD+). Ameliorates glucose intolerance by restoring NAD+ levels in high-fat diet (HFD)-induced T2D mice. Enhances hepatic insulin sensitivity and restores gene expression related to oxidative stress, inflammatory response, and circadian rhythm, partly through SIRT1 activation.
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Chemical Structure - beta-Nicotinamide mononucleotide, Key NAD+ intermediate (AB223879)
  • Chemical Structure

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Chemical Structure - beta-Nicotinamide mononucleotide, Key NAD+ intermediate (AB223879)

2D chemical structure image of ab223879, beta-Nicotinamide mononucleotide, Key NAD+ intermediate

Key facts

CAS number

1094-61-7

Purity

>98%

Form

Solid

form

Molecular weight

334.22 Da

Molecular formula

C<sub>1</sub><sub>1</sub>H<sub>1</sub><sub>5</sub>N<sub>2</sub>O<sub>8</sub>P

PubChem

14180

Nature

Synthetic

Solubility

Soluble in water to 100 mM

Biochemical name

Nicotinamide mononucleotide

Biological description

Product of the NAMPT reaction and a key intermediate in the biosynthesis of nicotinamide adenine dinucleotide (NAD+). Ameliorates glucose intolerance by restoring NAD+ levels in high-fat diet (HFD)-induced T2D mice. Enhances hepatic insulin sensitivity and restores gene expression related to oxidative stress, inflammatory response, and circadian rhythm, partly through SIRT1 activation.

Canonical smiles

C1=CC(=C[N+](=C1)C2C(C(C(O2)COP(=O)(O)[O-])O)O)C(=O)N

Isomeric smiles

C1=CC(=C[N+](=C1)[C@H]2[C@@H]([C@@H]([C@H](O2)COP(=O)(O)[O-])O)O)C(=O)N

InChi

InChI=1S/C11H15N2O8P/c12-10(16)6-2-1-3-13(4-6)11-9(15)8(14)7(21-11)5-20-22(17,18)19/h1-4,7-9,11,14-15H,5H2,(H3-,12,16,17,18,19)/t7-,8-,9-,11-/m1/s1

InChiKey

DAYLJWODMCOQEW-TURQNECASA-N

IUPAC Name

[(2R,3S,4R,5R)-5-(3-carbamoylpyridin-1-ium-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl hydrogen phosphate

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Product details

This product is manufactured by BioVision, an Abcam company and was previously called 2733 β-Nicotinamide mononucleotide. 2733-250 is the same size as the 250 mg size of ab223879.

Protect from air and moisture.

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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
Store under desiccating conditions
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Product protocols

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