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AB141280

Betamethasone valerate, Glucocorticoid; immunomodulator

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MW 476.6 Da, Purity >98%. Glucocorticoid. Major steroid hormone. Anti-inflammatory and immunosuppresive effects. Active in vivo.

View Alternative Names

AIS, ANDR_HUMAN, AR, AR8, Androgen nuclear receptor variant 2, Androgen receptor, Androgen receptor (dihydrotestosterone receptor; testicular feminization; spinal and bulbar muscular atrophy; Kennedy disease), BXR, DHTR, Dihydro testosterone receptor, Dihydrotestosterone receptor (DHTR), ERR a, ERR-alpha, ERR1 protein, ERR1_HUMAN, ESRL 1, ESRR A, Estrogen receptor related 1, Estrogen receptor-like 1, Estrogen-related receptor alpha, Estrra, GCCR, GCRST, GCR_HUMAN, GR, Glucocorticoid receptor, Grl1, HUMARA, HYSP1, IMD42, KD, Kennedy disease (KD), MGC129539, NR1B1, NR1F3, NR1I2_HUMAN, NR3B1, NR3C3, NR3C4, Nuclear mitotic apparatus protein retinoic acid receptor alpha fusion protein, Nuclear receptor ROR-gamma, Nuclear receptor RZR-gamma, Nuclear receptor subfamily 1 group B member 1, Nuclear receptor subfamily 1 group F member 3, Nuclear receptor subfamily 1 group I member 2, Nuclear receptor subfamily 3 group B member 1, Nuclear receptor subfamily 3 group C member 1, Nuclear receptor subfamily 3 group C member 3, Nuclear receptor subfamily 3 group C member 4, Nuclear receptor subfamily 3 group C member 4 (NR3C4), Nucleophosmin retinoic acid receptor alpha fusion protein NPM RAR long form, ONR 1, OTTHUMP00000215173, OTTHUMP00000215174, OTTHUMP00000215175, Orphan nuclear receptor PAR 1, Orphan nuclear receptor PXR, PAR, PAR q, PGR, PR, PRA, PRB, PRGR_HUMAN, PRR, Pregnane X receptor, Progesterone receptor, Progestin receptor form A, Progestin receptor form B, RAR, RAR related orphan nuclear receptor variant 2, RAR related orphan receptor C, isoform a, RAR related orphan receptor gamma, RAR-alpha, RAR-related orphan receptor C, RARA_HUMAN, RARalpha1, RORG_HUMAN, RZR GAMMA, RZRG, Retinoic acid binding receptor gamma, Retinoic acid nuclear receptor alpha variant 1, Retinoic acid nuclear receptor alpha variant 2, Retinoic acid receptor alpha, Retinoic acid receptor alpha polypeptide, Retinoid-related orphan receptor-gamma, Rorc, SBMA, SMAX1, SXR, Spinal and bulbar muscular atrophy, Spinal and bulbar muscular atrophy (SBMA), Steroid and xenobiotic receptor, Steroid hormone receptor ERR1, TFM, TOR, Testicular Feminization (TFM), androgen receptor splice variant 4b, estrogen receptor related receptor alpha, glucocorticoid nuclear receptor variant 1, hERR1, nr3c1, nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor), pregnane X nuclear receptor variant 2

1 Images
Chemical Structure - Betamethasone valerate, Glucocorticoid; immunomodulator (AB141280)
  • Chemical Structure

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Chemical Structure - Betamethasone valerate, Glucocorticoid; immunomodulator (AB141280)

2D chemical structure image of ab141280, Betamethasone valerate, Glucocorticoid; immunomodulator

Key facts

CAS number

2152-44-5

Purity

>98%

Form

Solid

form

Molecular weight

476.6 Da

Molecular formula

C<sub>2</sub><sub>7</sub>H<sub>3</sub><sub>7</sub>FO<sub>6</sub>

PubChem

16533

Nature

Synthetic

Solubility

Soluble in DMSO to 100 mM

Soluble in ethanol to 50 mM

Biochemical name

Betamethasone valerate

Biological description

Glucocorticoid. Major steroid hormone. Anti-inflammatory and immunosuppresive effects. Active in vivo.

Canonical smiles

CCCCC(=O)OC1(C(CC2C1(CC(C3(C2CCC4=CC(=O)C=CC43C)F)O)C)C)C(=O)CO

Isomeric smiles

CCCCC(=O)O[C@@]1([C@H](C[C@@H]2[C@@]1(C[C@@H]([C@]3([C@H]2CCC4=CC(=O)C=C[C@@]43C)F)O)C)C)C(=O)CO

InChi

InChI=1S/C27H37FO6/c1-5-6-7-23(33)34-27(22(32)15-29)16(2)12-20-19-9-8-17-13-18(30)10-11-24(17,3)26(19,28)21(31)14-25(20,27)4/h10-11,13,16,19-21,29,31H,5-9,12,14-15H2,1-4H3/t16-,19-,20-,21-,24-,25-,26-,27-/m0/s1

InChiKey

SNHRLVCMMWUAJD-SUYDQAKGSA-N

IUPAC Name

[(8S,9R,10S,11S,13S,14S,16S,17R)-9-fluoro-11-hydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl] pentanoate

Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
Ambient
Appropriate long-term storage conditions
Ambient
Storage information
Store under desiccating conditions|The product can be stored for up to 12 months

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The targets Glucocorticoid Receptor (GR) Progesterone Receptor (PR) Androgen Receptor (AR) Retinoic Acid Receptor alpha (RARα) Pregnane X Receptor (PXR) Estrogen Related Receptor alpha (ERRα) and ROR gamma (RORγ) are group of nuclear receptors that function as transcription factors. They regulate gene expression by binding to specific DNA sequences. GR also known as NR3C1 has a molecular weight of about 97 kDa and is widely expressed in many tissues including the liver lungs and immune cells. PR and AR are expressed primarily in reproductive tissues while RARα is prevalent in epithelial tissues. PXR and ERRα are found in the liver and heart respectively and RORγ is significantly expressed in the thymus.
Biological function summary

These nuclear receptors mediate responses to steroid hormones retinoids and other signaling molecules. They often form complexes with coactivators or corepressors to fine-tune gene transcription. GR modulates immune response and metabolism PR regulates reproductive functions AR and RARα play roles in cell differentiation and proliferation. PXR is a master regulator in xenobiotic metabolism while ERRα influences energy metabolism. RORγ is involved in circadian rhythm and immune functions especially in T cell development.

Pathways

Nuclear receptors such as GR and PXR play essential roles in the glucocorticoid signaling and xenobiotic detoxification pathways. GR is closely associated with metabolic pathways and responds to glucocorticoids like betamethasone while PXR activates genes involved in drug metabolism. AR and PR are integral to steroid signaling pathways. ERRα contributes to mitochondrial biogenesis pathways. RORγ interacts with pathways involved in immune system regulation. These receptors often interact with proteins such as coactivators and other nuclear receptors influencing broad cellular functions and responses.

Dysfunctional nuclear receptors have links to various conditions. GR and PXR dysregulation is associated with inflammatory disorders and metabolic syndrome. GR interacts with proteins managing inflammation influencing diseases like rheumatoid arthritis. AR alterations have connections to prostate cancer while PR is linked to breast cancer progression implicating their roles in reproductive system-related diseases. RORγ has relevance to autoimmune disorders due to its role in immune cell regulation. These associations make these nuclear receptors important therapeutic targets in pharmacology including the study of drugs like betamethasone and its derivatives for managing diseases.

Product protocols

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