MW 348.48 g/mol, Purity >99%. Potent RXR agonist (Ki values are 30.5, 16.4, 19.7, >1000 for RXRα, RXRβ, RXRγ and RAR respectively). Inhibits neurodegeneration and displays anticancer activity in vivo and in vitro. Blood-brain barrier permeable.
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- Brain pathology (Zurich, Switzerland) 33:e131262022Brain-specific loss of Abcg1 disturbs cholesterol metabolism and aggravates pyroptosis and neurological deficits after traumatic brain injury.Applications:Unspecified applicationReactive species:Unspecified reactive speciesHeng Xu,Le-Xin Zheng,Xue-Shi Chen,Qiu-Yu Pang,Ya-Nan Yan,Rong Liu,Han-Mu Guo,Zhi-Yang Ren,Yan Yang,Zhi-Ya Gu,Cheng Gao,Yuan Gao,Cheng-Liang Luo,Ying Zhao,Ying Wang,Tao Wang,Lu-Yang TaoPubMed 36271611
- Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society 30:585-5942022iTRAQ-derived quantitative proteomics uncovers the neuroprotective property of bexarotene in a mice model of cerebral ischemia-reperfusion injury.Applications:Unspecified applicationReactive species:Unspecified reactive speciesHailin Liu,Hu Wang,Sisi Chen,Shengwei Liu,Xiaocui Tian,Zhi Dong,Lu XuPubMed 35693438
- Neurochemical research 44:2809-28202019Bexarotene Attenuates Focal Cerebral Ischemia-Reperfusion Injury via the Suppression of JNK/Caspase-3 Signaling Pathway.Applications:Unspecified applicationReactive species:Unspecified reactive speciesHailin Liu et. al.PubMed 31680194
Key facts
- CAS number
- 153559-49-0
- Purity
- > 99%
- Form
- Solid
- Molecular weight
- 348.48 g/mol
- Molecular formula
- C24H28O2
- Nature
- Synthetic
Recommended products
MW 348.48 g/mol, Purity >99%. Potent RXR agonist (Ki values are 30.5, 16.4, 19.7, >1000 for RXRα, RXRβ, RXRγ and RAR respectively). Inhibits neurodegeneration and displays anticancer activity in vivo and in vitro. Blood-brain barrier permeable.
Key facts
- CAS number
- 153559-49-0
- Purity
- > 99%
- Form
- Solid
- Molecular weight
- 348.48 g/mol
- Molecular formula
- C24H28O2
- Nature
- Synthetic
- Solubility
Soluble in ethanol to 25 mM.
Soluble in DMSO to 50 mM.
- Biological description
Potent RXR agonist (Ki values are 30.5, 16.4, 19.7, >1000 for RXRα, RXRβ, RXRγ and RAR respectively). Inhibits neurodegeneration and displays anticancer activity in vivo and in vitro. Blood-brain barrier permeable.
- Canonical SMILES
- O=C(O)C1CCC(CC1)C(=C)C2CC3C(CC2C)C(C)(C)CCC3(C)C
- InChI
- InChI=1S/C24H28O2/c1-15-13-20-21(24(5,6)12-11-23(20,3)4)14-19(15)16(2)17-7-9-18(10-8-17)22(25)26/h7-10,13-14H,2,11-12H2,1,3-6H3,(H,25,26)
- InChIKey
- NAVMQTYZDKMPEU-UHFFFAOYSA-N
- IUPAC name
- 4-[1-(5,6,7,8-Tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)ethenyl]benzoic acid
Storage
- Shipped at conditions
- Ambient - Can Ship with Ice
- Appropriate short-term storage conditions
- -20°C
- Appropriate long-term storage conditions
- -20°C
- Storage information
- It is important to note that this product is reported to be light sensitive, Store in the dark, Store under desiccating conditions
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1 product image
Chemical Structure - Bexarotene, RXR agonist (ab141025)
2D chemical structure image of ab141025, Bexarotene, RXR agonist
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