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MW 348.48 g/mol, Purity >99%. Potent RXR agonist (Ki values are 30.5, 16.4, 19.7, >1000 for RXRα, RXRβ, RXRγ and RAR respectively). Inhibits neurodegeneration and displays anticancer activity in vivo and in vitro. Blood-brain barrier permeable.

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Images

Chemical Structure - Bexarotene, RXR agonist (AB141025), expandable thumbnail

Publications

Key facts

CAS number
153559-49-0
Purity
> 99%
Form
Solid
Molecular weight
348.48 g/mol
Molecular formula
C24H28O2
Nature
Synthetic

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MW 348.48 g/mol, Purity >99%. Potent RXR agonist (Ki values are 30.5, 16.4, 19.7, >1000 for RXRα, RXRβ, RXRγ and RAR respectively). Inhibits neurodegeneration and displays anticancer activity in vivo and in vitro. Blood-brain barrier permeable.

Key facts

Purity
> 99%
Solubility

Soluble in ethanol to 25 mM.

Soluble in DMSO to 50 mM.

Biological description

Potent RXR agonist (Ki values are 30.5, 16.4, 19.7, >1000 for RXRα, RXRβ, RXRγ and RAR respectively). Inhibits neurodegeneration and displays anticancer activity in vivo and in vitro. Blood-brain barrier permeable.

Canonical SMILES
O=C(O)C1CCC(CC1)C(=C)C2CC3C(CC2C)C(C)(C)CCC3(C)C
InChI
InChI=1S/C24H28O2/c1-15-13-20-21(24(5,6)12-11-23(20,3)4)14-19(15)16(2)17-7-9-18(10-8-17)22(25)26/h7-10,13-14H,2,11-12H2,1,3-6H3,(H,25,26)
InChIKey
NAVMQTYZDKMPEU-UHFFFAOYSA-N
IUPAC name
4-[1-(5,6,7,8-Tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)ethenyl]benzoic acid

Storage

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
It is important to note that this product is reported to be light sensitive, Store in the dark, Store under desiccating conditions

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1 product image

  • Chemical Structure - Bexarotene, RXR agonist (ab141025), expandable thumbnail

    Chemical Structure - Bexarotene, RXR agonist (ab141025)

    2D chemical structure image of ab141025, Bexarotene, RXR agonist

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Product protocols

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