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AB141025

Bexarotene, RXR agonist

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(3 Publications)

MW 348.48 g/mol, Purity >99%. Potent RXR agonist (Ki values are 30.5, 16.4, 19.7, >1000 for RXRα, RXRβ, RXRγ and RAR respectively). Inhibits neurodegeneration and displays anticancer activity in vivo and in vitro. Blood-brain barrier permeable.
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Chemical Structure - Bexarotene, RXR agonist (AB141025)
  • Chemical Structure

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Chemical Structure - Bexarotene, RXR agonist (AB141025)

2D chemical structure image of ab141025, Bexarotene, RXR agonist

Key facts

CAS number

153559-49-0

Purity

>99%

Form

Solid

form

Molecular weight

348.48 g/mol

Molecular formula

C<sub>2</sub><sub>4</sub>H<sub>2</sub><sub>8</sub>O<sub>2</sub>

Nature

Synthetic

Solubility

Soluble in ethanol to 25 mM

Soluble in DMSO to 50 mM

Biological description

Potent RXR agonist (Ki values are 30.5, 16.4, 19.7, >1000 for RXRα, RXRβ, RXRγ and RAR respectively). Inhibits neurodegeneration and displays anticancer activity in vivo and in vitro. Blood-brain barrier permeable.

Canonical smiles

O=C(O)C1CCC(CC1)C(=C)C2CC3C(CC2C)C(C)(C)CCC3(C)C

InChi

InChI=1S/C24H28O2/c1-15-13-20-21(24(5,6)12-11-23(20,3)4)14-19(15)16(2)17-7-9-18(10-8-17)22(25)26/h7-10,13-14H,2,11-12H2,1,3-6H3,(H,25,26)

InChiKey

NAVMQTYZDKMPEU-UHFFFAOYSA-N

IUPAC Name

4-[1-(5,6,7,8-Tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)ethenyl]benzoic acid

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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
It is important to note that this product is reported to be light sensitive|Store in the dark|Store under desiccating conditions
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Product protocols

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Publications (3)

Recent publications for all applications. Explore the full list and refine your search

Brain pathology (Zurich, Switzerland) 33:e13126 PubMed36271611

2022

Brain-specific loss of Abcg1 disturbs cholesterol metabolism and aggravates pyroptosis and neurological deficits after traumatic brain injury.

Applications

Unspecified application

Species

Unspecified reactive species

Heng Xu,Le-Xin Zheng,Xue-Shi Chen,Qiu-Yu Pang,Ya-Nan Yan,Rong Liu,Han-Mu Guo,Zhi-Yang Ren,Yan Yang,Zhi-Ya Gu,Cheng Gao,Yuan Gao,Cheng-Liang Luo,Ying Zhao,Ying Wang,Tao Wang,Lu-Yang Tao

Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society 30:585-594 PubMed35693438

2022

iTRAQ-derived quantitative proteomics uncovers the neuroprotective property of bexarotene in a mice model of cerebral ischemia-reperfusion injury.

Applications

Unspecified application

Species

Unspecified reactive species

Hailin Liu,Hu Wang,Sisi Chen,Shengwei Liu,Xiaocui Tian,Zhi Dong,Lu Xu

Neurochemical research 44:2809-2820 PubMed31680194

2019

Bexarotene Attenuates Focal Cerebral Ischemia-Reperfusion Injury via the Suppression of JNK/Caspase-3 Signaling Pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Hailin Liu,Shengwei Liu,Xiaocui Tian,Qian Wang,Jiangyan Rao,Yucun Wang,Fei Xiang,Hang Zheng,Lu Xu,Zhi Dong
View all publications
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