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AB287027

BI-409306 (Osoresnontrine)

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MW 311.34 Da, Purity >98%. BI-409306 is a potent and selective PDE9A inhibitor (IC50 = 52 nM). Displays weak activity against other PDEs, such as PDE1A (IC50, 1.4 μM), PDE1C (IC50, 1.0 μM), PDE2A, PDE3A, PDE4B, PDE5A, PDE6AB, PDE7A, and PDE10A (IC50 > 10 μM). Potentially could be useful for the treatment of Alzheimer's disease and Schizophrenia.

Key facts

CAS number

1189767-28-9

Purity

>98%

Form

Solid

form

Molecular weight

311.34 Da

Molecular formula

C<sub>1</sub><sub>6</sub>H<sub>1</sub><sub>7</sub>N<sub>5</sub>O<sub>2</sub>

PubChem

135908617

Nature

Synthetic

Solubility

Soluble in DMSO to >100 mM

Biochemical name

Osoresnontrine

Biological description

BI-409306 is a potent and selective PDE9A inhibitor (IC50 = 52 nM). Displays weak activity against other PDEs, such as PDE1A (IC50, 1.4 μM), PDE1C (IC50, 1.0 μM), PDE2A, PDE3A, PDE4B, PDE5A, PDE6AB, PDE7A, and PDE10A (IC50 > 10 μM). Potentially could be useful for the treatment of Alzheimer's disease and Schizophrenia.

Canonical smiles

C1COCCC1N2C3=C(C=N2)C(=O)NC(=N3)CC4=CC=CC=N4

InChi

InChI=1S/C16H17N5O2/c22-16-13-10-18-21(12-4-7-23-8-5-12)15(13)19-14(20-16)9-11-3-1-2-6-17-11/h1-3,6,10,12H,4-5,7-9H2,(H,19,20,22)

InChiKey

BZTIJCSHNVZMES-UHFFFAOYSA-N

IUPAC Name

1-(oxan-4-yl)-6-(pyridin-2-ylmethyl)-5H-pyrazolo[3,4-d]pyrimidin-4-one

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Product details

This product is manufactured by BioVision, an Abcam company and was previously called B2377 BI-409306. B2377-25 is the same size as the 25 mg size of ab287027.
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate long-term storage conditions
-20°C
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Product protocols

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