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AB254451

BI-D1870, RSK Inhibitor

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MW 391.4 Da, Purity >98%. Cell-permeable, ATP-competitive p90 ribosomal S6 kinase (RSK) inhibitor (RSK1 IC50 = 31 nM; RSK2 IC50 = 24 nM; RSK3 IC50 = 18 nM; RSK4 IC50 = 15 nM). Selective (10 to 100-fold) over MST2, GSK-3 beta, MARK3, CK1 and Aurora B. Inhibits RSK-mediated phorbol ester- and EGF -induced phosphorylation of glycogen synthase kinase-3β and LKB1 in cell models. May have RSK-independent effects on mTORC1-p70S6K and p21WAF1/CIP1 pathways.
1 Images
Chemical Structure - BI-D1870, RSK Inhibitor (AB254451)
  • Chemical Structure

Supplier Data

Chemical Structure - BI-D1870, RSK Inhibitor (AB254451)

2D chemical structure image of ab254451, BI-D1870, RSK Inhibitor

Key facts

CAS number

501437-28-1

Purity

>98%

Form

Solid

form

Molecular weight

391.4 Da

Molecular formula

C<sub>1</sub><sub>9</sub>H<sub>2</sub><sub>3</sub>F<sub>2</sub>N<sub>5</sub>O<sub>2</sub>

PubChem

25023738

Nature

Synthetic

Solubility

Soluble in DMSO to 25 mM

Biochemical name

2-((3,5-difluoro-4-hydroxyphenyl)amino)-8-isopentyl-5,7-dimethyl-7,8-dihydropteridin-6(5H)-one

Biological description

Cell-permeable, ATP-competitive p90 ribosomal S6 kinase (RSK) inhibitor (RSK1 IC50 = 31 nM; RSK2 IC50 = 24 nM; RSK3 IC50 = 18 nM; RSK4 IC50 = 15 nM). Selective (10 to 100-fold) over MST2, GSK-3 beta, MARK3, CK1 and Aurora B. Inhibits RSK-mediated phorbol ester- and EGF -induced phosphorylation of glycogen synthase kinase-3β and LKB1 in cell models. May have RSK-independent effects on mTORC1-p70S6K and p21WAF1/CIP1 pathways.

Canonical smiles

CC1C(=O)N(C2=CN=C(N=C2N1CCC(C)C)NC3=CC(=C(C(=C3)F)O)F)C

InChi

InChI=1S/C19H23F2N5O2/c1-10(2)5-6-26-11(3)18(28)25(4)15-9-22-19(24-17(15)26)23-12-7-13(20)16(27)14(21)8-12/h7-11,27H,5-6H2,1-4H3,(H,22,23,24)

InChiKey

DTEKTGDVSARYDS-UHFFFAOYSA-N

IUPAC Name

2-(3,5-difluoro-4-hydroxyanilino)-5,7-dimethyl-8-(3-methylbutyl)-7H-pteridin-6-one

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Complementary Products

Secondary Antibodies

AB150077

Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488)

Immunocytochemistry/ Immunofluorescence - Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (AB150077)

  • 5
  • 20
Primary Antibodies

AB206652

Anti-Casein Kinase 1 alpha antibody [EPR19824]

RabMAb|Recombinant|KO Validated|Trial Size

Immunoprecipitation - Anti-Casein Kinase 1 alpha antibody [EPR19824] (AB206652)

  • 5
  • 2
Proteins & Peptides

AB102102

Recombinant human Casein Kinase 1 alpha protein

Functional Studies - Recombinant human Casein Kinase 1 alpha protein (AB102102)

  • 0
  • 0
Primary Antibodies

AB15580

Anti-Ki67 antibody

BOND RX™ Validated|KO Validated

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Ki67 antibody (AB15580)

  • 5
  • 230
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Product details

Solutions in DMSO may be stored at -20°C for up to 1 month.
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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
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Product protocols

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Product promise

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