Bicalutamide (ICI176334), Androgen receptor antagonist

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Progesterone receptor Maxi Potassium channel alpha (also known as SLO) Maxi Potassium channel beta (KCNMB1) Androgen Receptor and additional subunits like KCNMB4 KCNMB2 and LRRC26 play important roles in cellular processes. The progesterone receptor is an intracellular receptor with a mass of approximately 99 kDa and is expressed in tissues like uterus and mammary glands. The Maxi Potassium channels comprising alpha and beta subunits regulate ion flow across membranes important for maintaining cellular homeostasis. These channels and receptors are also detected in the nervous system cardiovascular tissues and other excitable tissues.

Biological function summary

These proteins influence several physiological functions. Progesterone receptor acts by regulating gene expression essential for reproduction and pregnancy maintenance. Maxi Potassium channels are key to controlling neuronal excitability and muscle contraction. Androgen Receptor part of a steroid hormone receptor family regulates genes related to male sexual development and maintenance. It acts within a complex involving heat shock proteins facilitating the receptor's proper folding and function. These proteins also interact with various ligands affecting their biological actions further.

Pathways

The Progesterone and Androgen Receptors participate in steroid signaling pathways influencing gene expression and cell growth. The Progesterone Receptor links to the uterine decidualization pathway while the Androgen Receptor involves the androgen-signaling cascade essential for the development of male characteristics. Maxi Potassium channels are integrated into cellular excitability pathways managing the membrane potential and involved in coupling with calcium signaling proteins. These pathways ensure proper physiological responses and cellular communications.

These targets relate to conditions like breast cancer and hypertension. Progesterone Receptor plays a role in hormone-sensitive breast cancer often targeted by hormone therapies such as bicalutamide an androgen receptor antagonist. The Maxi Potassium channels are associated with hypertension due to their role in blood vessel tone regulation. Mutations or dysregulation of these channels and receptors can significantly impact disease progression. Understanding these proteins offers potential therapeutic avenues targeting their biological and molecular mechanisms.