MW 509.3 Da, Purity >99%. Water-soluble GABAA antagonist. Methiodide salt of (+)-bicuculline (ab120107). Actions on neuronal Ca2+-activated K+ channels reported.
Soluble in 1 ml water to give specified mM/ml concentration.
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- PloS one 8:e589012013Muscarinic depolarization of layer II neurons of the parasubiculum.Applications:Unspecified applicationReactive species:Unspecified reactive speciesStephen D Glasgow et. al.PubMed 23520542
- Neuron 75:58-642012Striatal dopamine release is triggered by synchronized activity in cholinergic interneurons.Applications:Unspecified applicationReactive species:Unspecified reactive speciesSarah Threlfell,Tatjana Lalic,Nicola J Platt,Katie A Jennings,Karl Deisseroth,Stephanie J CraggPubMed 22794260
- PloS one 7:e363972012Striatal dopamine transmission is subtly modified in human A53Tα-synuclein overexpressing mice.Applications:Unspecified applicationReactive species:Unspecified reactive speciesNicola J Platt et. al.PubMed 22570709
- The Journal of neuroscience : the official journal of the Society for Neuroscience 32:572-822012GABA is excitatory in adult vasopressinergic neuroendocrine cells.Applications:Unspecified applicationReactive species:Unspecified reactive speciesJuhee Haam,Ion R Popescu,Linda A Morton,Katalin C Halmos,Ryoichi Teruyama,Yoichi Ueta,Jeffrey G TaskerPubMed 22238092
- British journal of pharmacology 161:925-352010N-arachidonyl-glycine modulates synaptic transmission in superficial dorsal horn.Applications:Unspecified applicationReactive species:Unspecified reactive speciesHyo-Jin Jeong,Robert J Vandenberg,Christopher W VaughanPubMed 20860669
- Cerebral cortex (New York, N.Y. : 1991) 21:413-242010Neuronal network formation from reprogrammed early postnatal rat cortical glial cells.Applications:Unspecified applicationReactive species:Unspecified reactive speciesRobert Blum,Christophe Heinrich,Rodrigo Sánchez,Alexandra Lepier,Eckart D Gundelfinger,Benedikt Berninger,Magdalena GötzPubMed 20562320
Key facts
- CAS number
- 40709-69-1
- Purity
- > 99%
- Form
- Solid
- Molecular weight
- 509.3 Da
- Molecular formula
- C21H20INO6
- PubChem identifier
- 185826
- Nature
- Synthetic
Recommended products
MW 509.3 Da, Purity >99%. Water-soluble GABAA antagonist. Methiodide salt of (+)-bicuculline (ab120107). Actions on neuronal Ca2+-activated K+ channels reported.
Soluble in 1 ml water to give specified mM/ml concentration.
Key facts
- CAS number
- 40709-69-1
- Purity
- > 99%
- Form
- Solid
- Molecular weight
- 509.3 Da
- Molecular formula
- C21H20INO6
- PubChem identifier
- 185826
- Nature
- Synthetic
- Solubility
Soluble in water to 10 mM.
- Biochemical name
- (6S)-6-[(5R)-6,6-Dimethyl-7,8-dihydro-5H-[1,3]dioxolo[4,5-g]isoquinolin-6-ium-5-yl]-6H-furo[3,4-g][1,3]benzodioxol-8-one;iodide
- Biological description
Water-soluble GABAA antagonist. Methiodide salt of (+)-bicuculline (ab120107). Actions on neuronal Ca2+-activated K+ channels reported.
Soluble in 1 ml water to give specified mM/ml concentration.- Canonical SMILES
- C[N+]1(CCC2=CC3=C(C=C2C1C4C5=C(C6=C(C=C5)OCO6)C(=O)O4)OCO3)C.[I-]
- Isomeric SMILES
- C[N+]1(CCC2=CC3=C(C=C2[C@@H]1[C@@H]4C5=C(C6=C(C=C5)OCO6)C(=O)O4)OCO3)C.[I-]
- InChI
- InChI=1S/C21H20NO6.HI/c1-22(2)6-5-11-7-15-16(26-9-25-15)8-13(11)18(22)19-12-3-4-14-20(27-10-24-14)17(12)21(23)28-19;/h3-4,7-8,18-19H,5-6,9-10H2,1-2H3;1H/q+1;/p-1/t18-,19+;/m1./s1
- InChIKey
- HKJKCPKPSSVUHY-VOMIJIAVSA-M
- IUPAC name
- (6S)-6-[(5R)-6,6-dimethyl-7,8-dihydro-5H-[1,3]dioxolo[4,5-g]isoquinolin-6-ium-5-yl]-6H-furo[3,4-g][1,3]benzodioxol-8-one;iodide
Storage
- Shipped at conditions
- Ambient - Can Ship with Ice
- Appropriate long-term storage conditions
- +4°C
- Storage information
- Store under desiccating conditions, The product can be stored for up to 12 months
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1 product image
Chemical Structure - (-)-Bicuculline methiodide (mM/ml), GABAA antagonist (ab144491)
2D chemical structure image of ab144491, (-)-Bicuculline methiodide (mM/ml), GABAA antagonist
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