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AB273599

BIIB 021

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MW 318.76 Da, Purity >98%. Selective, Hsp90 competitive inhibitor (Ki = 1.7 nM). Displays no significant activity at a range of ATP-binding kinases or Na+K+ ATPase. Induces degradation of HER-2 in vitro (EC50 = 38 nM in MCF-7 cells). Inhibits growth and promotes cell death in a variety of human tumor cells. Orally bioavailable.
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Chemical Structure - BIIB 021 (AB273599)
  • Chemical Structure

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Chemical Structure - BIIB 021 (AB273599)

Chemical structure of BIIB 021, 848695-25-0

Key facts

CAS number

848695-25-0

Purity

>98%

Form

Solid

form

Molecular weight

318.76 Da

Molecular formula

C<sub>1</sub><sub>4</sub>H<sub>1</sub><sub>5</sub>ClN<sub>6</sub>O

PubChem

16736529

Nature

Synthetic

Solubility

Soluble in DMSO to 100 mM

Biochemical name

6-chloro-9-((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)-9H-purin-2-amine

Biological description

Selective, Hsp90 competitive inhibitor (Ki = 1.7 nM). Displays no significant activity at a range of ATP-binding kinases or Na+K+ ATPase. Induces degradation of HER-2 in vitro (EC50 = 38 nM in MCF-7 cells). Inhibits growth and promotes cell death in a variety of human tumor cells. Orally bioavailable.

Canonical smiles

CC1=CN=C(C(=C1OC)C)CN2C=NC3=C2N=C(N=C3Cl)N

InChi

InChI=1S/C14H15ClN6O/c1-7-4-17-9(8(2)11(7)22-3)5-21-6-18-10-12(15)19-14(16)20-13(10)21/h4,6H,5H2,1-3H3,(H2,16,19,20)

InChiKey

QULDDKSCVCJTPV-UHFFFAOYSA-N

IUPAC Name

6-chloro-9-[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]purin-2-amine

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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
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Product protocols

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