MW 533.9 Da, Purity >98%. Cell-permeable, adenine-thymine selective DNA fluorescent stain. DNA minor groove-directed agent. Labels DNA, chromosomes and nuclei. Stimulates topoisomerase I-mediated DNA cleavage. Bisbenzimide H 33342 (ab145596) analog.
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- Proceedings of the National Academy of Sciences of the United States of America 119:e22090421192022Inhibition of major histocompatibility complex-I antigen presentation by sarbecovirus ORF7a proteins.Applications:Unspecified applicationReactive species:Unspecified reactive speciesFengwen Zhang,Trinity M Zang,Eva M Stevenson,Xiao Lei,Dennis C Copertino,Talia M Mota,Julie Boucau,Wilfredo F Garcia-Beltran,R Brad Jones,Paul D BieniaszPubMed 36136978
- Redox biology 4:48-592014The role of the catecholic and the electrophilic moieties of caffeic acid in Nrf2/Keap1 pathway activation in ovarian carcinoma cell lines.Applications:Unspecified applicationReactive species:Unspecified reactive speciesR Sirota,D Gibson,R KohenPubMed 25498967
Key facts
- CAS number
- 23491-45-4
- Purity
- > 98%
- Form
- Solid
- Molecular weight
- 533.9 Da
- Molecular formula
- C25H27Cl3N6O
- PubChem identifier
- 5360743
- Nature
- Synthetic
- Excitation/Emission
- Ex: 350nm, Em: 461nm
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MW 533.9 Da, Purity >98%. Cell-permeable, adenine-thymine selective DNA fluorescent stain. DNA minor groove-directed agent. Labels DNA, chromosomes and nuclei. Stimulates topoisomerase I-mediated DNA cleavage. Bisbenzimide H 33342 (ab145596) analog.
Key facts
- CAS number
- 23491-45-4
- Purity
- > 98%
- Form
- Solid
- Molecular weight
- 533.9 Da
- Molecular formula
- C25H27Cl3N6O
- PubChem identifier
- 5360743
- Nature
- Synthetic
- Solubility
Soluble in water to 10 mM.
- Biochemical name
- CID 5360743
- Biological description
Cell-permeable, adenine-thymine selective DNA fluorescent stain. DNA minor groove-directed agent. Labels DNA, chromosomes and nuclei. Stimulates topoisomerase I-mediated DNA cleavage. Bisbenzimide H 33342 (ab145596) analog.
- Canonical SMILES
- CN1CCN(CC1)C2=CC3=C(C=C2)N=C(N3)C4=CC5=C(C=C4)NC(=C6C=CC(=O)C=C6)N5.Cl.Cl.Cl
- Isomeric SMILES
- CN1CCN(CC1)C2=CC3=C(C=C2)N=C(N3)C4=CC5=C(C=C4)NC(=C6C=CC(=O)C=C6)N5.Cl.Cl.Cl
- InChI
- InChI=1S/C25H24N6O.3ClH/c1-30-10-12-31(13-11-30)18-5-9-21-23(15-18)29-25(27-21)17-4-8-20-22(14-17)28-24(26-20)16-2-6-19(32)7-3-16;;;/h2-9,14-15,26,28H,10-13H2,1H3,(H,27,29);3*1H
- InChIKey
- OKQAASMPIOSOEX-UHFFFAOYSA-N
- IUPAC name
- 4-[5-[6-(4-methylpiperazin-1-yl)-1H-benzimidazol-2-yl]-1,3-dihydrobenzimidazol-2-ylidene]cyclohexa-2,5-dien-1-one;trihydrochloride
- Excitation/Emission
- Ex: 350nm, Em: 461nm
Storage
- Shipped at conditions
- Ambient - Can Ship with Ice
- Appropriate short-term storage conditions
- -20°C
- Appropriate long-term storage conditions
- -20°C
- Storage information
- Store under desiccating conditions, The product can be stored for up to 12 months
Notes
This product is manufactured by BioVision, an Abcam company and was previously called 2178 bisBenzimide H 33258. 2178-100 is the same size as the 100 mg size of ab145596.
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1 product image
Chemical Structure - Bisbenzimide H 33258 (Hoechst 33258), adenine-thymine selective DNA fluorescent stain (ab145596)
2D chemical structure image of ab145596, Bisbenzimide H 33258 (Hoechst 33258), adenine-thymine selective DNA fluorescent stain
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