MW 561.9 Da, Purity >98%. Cell-permeable, adenine-thymine selective DNA fluorescent stain. DNA minor groove-directed agent. Labels DNA, chromosomes and nuclei. Stimulates topoisomerase I-mediated DNA cleavage. Bisbenzimide H 33258 (ab145596) analog.
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- Nature 607:756-7612022Oocytes maintain ROS-free mitochondrial metabolism by suppressing complex I.Applications:Unspecified applicationReactive species:Unspecified reactive speciesAida Rodríguez-Nuevo,Ariadna Torres-Sanchez,Juan M Duran,Cristian De Guirior,Maria Angeles Martínez-Zamora,Elvan BökePubMed 35859172
- EMBO reports 23:e540492022Intra-epithelial non-canonical Activin A signaling safeguards prostate progenitor quiescence.Applications:Unspecified applicationReactive species:Unspecified reactive speciesFrancesco Cambuli,Veronica Foletto,Alessandro Alaimo,Dario De Felice,Francesco Gandolfi,Maria Dilia Palumbieri,Michela Zaffagni,Sacha Genovesi,Marco Lorenzoni,Martina Celotti,Emiliana Bertossio,Giosuè Mazzero,Arianna Bertossi,Alessandra Bisio,Francesco Berardinelli,Antonio Antoccia,Marco Gaspari,Mattia Barbareschi,Michelangelo Fiorentino,Michael M Shen,Massimo Loda,Alessandro Romanel,Andrea LunardiPubMed 35253958
- Cancer letters 534:2156122022ETS-related gene (ERG) undermines genome stability in mouse prostate progenitors via Gsk3β dependent Nkx3.1 degradation.Applications:Unspecified applicationReactive species:Unspecified reactive speciesMarco Lorenzoni,Dario De Felice,Giulia Beccaceci,Giorgia Di Donato,Veronica Foletto,Sacha Genovesi,Arianna Bertossi,Francesco Cambuli,Francesca Lorenzin,Aurora Savino,Lidia Avalle,Alessia Cimadamore,Rodolfo Montironi,Veronica Weber,Francesco Giuseppe Carbone,Mattia Barbareschi,Francesca Demichelis,Alessandro Romanel,Valeria Poli,Giannino Del Sal,Marianna Kruithof-de Julio,Marco Gaspari,Alessandro Alaimo,Andrea LunardiPubMed 35259458
- Veterinary microbiology 255:1090172021Bovine respiratory coronavirus enhances bacterial adherence by upregulating expression of cellular receptors on bovine respiratory epithelial cells.Applications:Unspecified applicationReactive species:Unspecified reactive speciesWatcharapong Fahkrajang,Putu Eka Sudaryatma,Hirohisa Mekata,Saori Hamabe,Akatsuki Saito,Tamaki OkabayashiPubMed 33639390
- Journal of neurointerventional surgery :2020Endothelialized silicone aneurysm models for in vitro evaluation of flow diverters.Applications:Unspecified applicationReactive species:Unspecified reactive speciesAlyssa McCulloch et. al.PubMed 33106319
- Veterinary microbiology 246:1087482020Bovine Respiratory Syncytial Virus Decreased Pasteurella multocida Adherence by Downregulating the Expression of Intercellular Adhesion Molecule-1 on the Surface of Upper Respiratory Epithelial Cells.Applications:Unspecified applicationReactive species:Unspecified reactive speciesPutu Eka Sudaryatma et. al.PubMed 32605748
- Oncotarget 11:1603-16172020Quinacrine inhibits GSTA1 activity and induces apoptosis through G/S arrest and generation of ROS in human non-small cell lung cancer cell lines.Applications:Unspecified applicationReactive species:Unspecified reactive speciesMakhan Kumar,Ansie Martin,Snehal Nirgude,Bibha Chaudhary,Sukanta Mondal,Angshuman SarkarPubMed 32405336
- Bioscience reports 39:2019Liraglutide inhibits the apoptosis of human nucleus pulposus cells induced by high glucose through PI3K/Akt/caspase-3 signaling pathway.Applications:Unspecified applicationReactive species:Unspecified reactive speciesYao Ming-Yan et. al.PubMed 31383790
- Veterinary microbiology 235:80-852019Co-infection of epithelial cells established from the upper and lower bovine respiratory tract with bovine respiratory syncytial virus and bacteria.Applications:Unspecified applicationReactive species:Unspecified reactive speciesPutu Eka Sudaryatma et. al.PubMed 31282382
- Journal of equine veterinary science 78:1-52019Immunolocalization of Leptin and its Receptor (ObR-b) in Equine Placenta at Term and Plasma Level Measurement in the Late Gestation.Applications:Unspecified applicationReactive species:Unspecified reactive speciesFernanda Maria Pazinato et. al.PubMed 31203970
Key facts
- CAS number
- 875756-97-1
- Purity
- > 98%
- Form
- Solid
- Molecular weight
- 561.9 Da
- Molecular formula
- C27H31Cl3N6O
- PubChem identifier
- 16760503
- Nature
- Synthetic
- Excitation/Emission
- Ex: 360nm, Em: 600nm
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MW 561.9 Da, Purity >98%. Cell-permeable, adenine-thymine selective DNA fluorescent stain. DNA minor groove-directed agent. Labels DNA, chromosomes and nuclei. Stimulates topoisomerase I-mediated DNA cleavage. Bisbenzimide H 33258 (ab145596) analog.
Key facts
- CAS number
- 875756-97-1
- Purity
- > 98%
- Form
- Solid
- Molecular weight
- 561.9 Da
- Molecular formula
- C27H31Cl3N6O
- PubChem identifier
- 16760503
- Nature
- Synthetic
- Solubility
Soluble in water to 75 mM.
- Biochemical name
- Bisbenzimide ethoxide trihydrochloride
- Biological description
Cell-permeable, adenine-thymine selective DNA fluorescent stain. DNA minor groove-directed agent. Labels DNA, chromosomes and nuclei. Stimulates topoisomerase I-mediated DNA cleavage. Bisbenzimide H 33258 (ab145596) analog.
- Canonical SMILES
- CCOC1=CC=C(C=C1)C2=NC3=C(N2)C=C(C=C3)C4=NC5=C(N4)C=C(C=C5)N6CCN(CC6)C.Cl.Cl.Cl
- InChI
- InChI=1S/C27H28N6O.3ClH/c1-3-34-21-8-4-18(5-9-21)26-28-22-10-6-19(16-24(22)30-26)27-29-23-11-7-20(17-25(23)31-27)33-14-12-32(2)13-15-33;;;/h4-11,16-17H,3,12-15H2,1-2H3,(H,28,30)(H,29,31);3*1H
- InChIKey
- JABNPSKWVNCGMX-UHFFFAOYSA-N
- IUPAC name
- 2-(4-ethoxyphenyl)-6-[6-(4-methylpiperazin-1-yl)-1H-benzimidazol-2-yl]-1H-benzimidazole;trihydrochloride
- Excitation/Emission
- Ex: 360nm, Em: 600nm
Storage
- Shipped at conditions
- Ambient - Can Ship with Ice
- Appropriate short-term storage conditions
- -20°C
- Appropriate long-term storage conditions
- -20°C
- Storage information
- Store under desiccating conditions, The product can be stored for up to 12 months
Notes
This product is manufactured by BioVision, an Abcam company and was previously called 2179 bisBenzimide H 33342. 2179-100 is the same size as the 100 mg size of ab145597.
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1 product image
Chemical Structure - Bisbenzimide H 33342 (Hoechst 33342), adenine-thymine selective DNA fluorescent stain (ab145597)
2D chemical structure image of ab145597, Bisbenzimide H 33342 (Hoechst 33342), adenine-thymine selective DNA fluorescent stain
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