MW 308.33 g/mol, Purity >98%. Apoptotic anticancer, anti-inflammatory and antioxidant curcuminoid. Inhibits wnt activity through activation of WIF-1. Induces demethylation through DNA methyltransferase 1 inhibition. Potent and competitive aldo-keto reductase inhibitor (Ki = 22 nM).
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Key facts
- CAS number
- 33171-05-0
- Purity
- > 98%
- Form
- Solid
- Molecular weight
- 308.33 g/mol
- Molecular formula
- C19H16O4
- Nature
- Synthetic
Recommended products
MW 308.33 g/mol, Purity >98%. Apoptotic anticancer, anti-inflammatory and antioxidant curcuminoid. Inhibits wnt activity through activation of WIF-1. Induces demethylation through DNA methyltransferase 1 inhibition. Potent and competitive aldo-keto reductase inhibitor (Ki = 22 nM).
Key facts
- CAS number
- 33171-05-0
- Purity
- > 98%
- Form
- Solid
- Molecular weight
- 308.33 g/mol
- Molecular formula
- C19H16O4
- Nature
- Synthetic
- Solubility
Soluble in DMSO to 100 mM.
- Biological description
Apoptotic anticancer, anti-inflammatory and antioxidant curcuminoid. Inhibits wnt activity through activation of WIF-1. Induces demethylation through DNA methyltransferase 1 inhibition. Potent and competitive aldo-keto reductase inhibitor (Ki = 22 nM).
- IUPAC name
- (1E,6E)-1,7-Bis(4-hydroxyphenyl)-1,6-heptadiene-3,5-dione
Storage
- Shipped at conditions
- Ambient - Can Ship with Ice
- Appropriate short-term storage conditions
- -20°C
- Appropriate long-term storage conditions
- -20°C
- Storage information
- It is important to note that this product is reported to be light sensitive, Store in the dark, Store under desiccating conditions
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2 product images
Chemical Structure - Bisdemethoxycurcumin, Apoptotic curcuminoid (ab120976)
2D chemical structure image of ab120976, Bisdemethoxycurcumin, Apoptotic curcuminoid
Functional Studies - Bisdemethoxycurcumin, Apoptotic curcuminoid (ab120976)
ab18210 staining Bcl2 in HeLa cells treated with bisdemethoxycurcumin (ab120976), by ICC/IF. Decrease of Bcl2 expression correlates with increased concentration of bisdemethoxycurcumin, as described in literature.
The cells were incubated at 37°C for 6 hours in media containing different concentrations of ab120976 (bisdemethoxycurcumin) in DMSO, fixed with 100% methanol for 5 minutes at -20°C and blocked with PBS containing 10% goat serum, 0.3 M glycine, 1% BSA and 0.1% tween for 2h at room temperature. Staining of the treated cells with ab18209 (5 µg/ml) was performed overnight at 4°C in PBS containing 1% BSA and 0.1% tween. A DyLight 488 anti-rabbit polyclonal antibody (Goat Anti-Rabbit IgG H&L (DyLight® 488) preadsorbed ab96899) at 1/250 dilution was used as the secondary antibody. Nuclei were counterstained with DAPI and are shown in blue.
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