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AB120976

Bisdemethoxycurcumin, Apoptotic curcuminoid

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MW 308.33 g/mol, Purity >98%. Apoptotic anticancer, anti-inflammatory and antioxidant curcuminoid. Inhibits wnt activity through activation of WIF-1. Induces demethylation through DNA methyltransferase 1 inhibition. Potent and competitive aldo-keto reductase inhibitor (Ki = 22 nM).
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Functional Studies - Bisdemethoxycurcumin, Apoptotic curcuminoid (AB120976)
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Functional Studies - Bisdemethoxycurcumin, Apoptotic curcuminoid (AB120976)

ab18210 staining Bcl2 in HeLa cells treated with bisdemethoxycurcumin (ab120976), by ICC/IF. Decrease of Bcl2 expression correlates with increased concentration of bisdemethoxycurcumin, as described in literature.
The cells were incubated at 37°C for 6 hours in media containing different concentrations of ab120976 (bisdemethoxycurcumin) in DMSO, fixed with 100% methanol for 5 minutes at -20°C and blocked with PBS containing 10% goat serum, 0.3 M glycine, 1% BSA and 0.1% tween for 2h at room temperature. Staining of the treated cells with ab18209 (5 µg/ml) was performed overnight at 4°C in PBS containing 1% BSA and 0.1% tween. A DyLight® 488 anti-rabbit polyclonal antibody (ab96899) at 1/250 dilution was used as the secondary antibody. Nuclei were counterstained with DAPI and are shown in blue.

Chemical Structure - Bisdemethoxycurcumin, Apoptotic curcuminoid (AB120976)
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Chemical Structure - Bisdemethoxycurcumin, Apoptotic curcuminoid (AB120976)

2D chemical structure image of ab120976, Bisdemethoxycurcumin, Apoptotic curcuminoid

Key facts

CAS number

33171-05-0

Purity

>98%

Form

Solid

form

Molecular weight

308.33 g/mol

Molecular formula

C<sub>1</sub><sub>9</sub>H<sub>1</sub><sub>6</sub>O<sub>4</sub>

Nature

Synthetic

Solubility

Soluble in DMSO to 100 mM

Biological description

Apoptotic anticancer, anti-inflammatory and antioxidant curcuminoid. Inhibits wnt activity through activation of WIF-1. Induces demethylation through DNA methyltransferase 1 inhibition. Potent and competitive aldo-keto reductase inhibitor (Ki = 22 nM).

IUPAC Name

(1E,6E)-1,7-Bis(4-hydroxyphenyl)-1,6-heptadiene-3,5-dione

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Primary Antibodies

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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
It is important to note that this product is reported to be light sensitive|Store in the dark|Store under desiccating conditions
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Product protocols

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