Bisindolylmaleimide IV, PKC inhibitor

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MW 327.3 Da, Purity >98%. Potent cell-permeable PKC inhibitor (IC₅₀ values are 0.1 - 0.55 μM). Inhibits PKA (IC₅₀ values are 2 - 11.8 μM). Noncompetitive nAChR antagonist. Shows less potent antinicotinic effects than Bisindolylmaleimide II (ab144206). Induces apoptosis and shows antiproliferative effects.

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14-3-3-zetaisoform, AI098070, Atypical protein kinase C-lambda/iota, C80388, CAM kinase 2 delta, CAM kinase II delta, CAMK 2d, CAMKD, CAMKI, CVID9, CaM kinase II delta subunit, CaM kinase II subunit delta, CaM-kinase II delta chain, CaMK-II delta subunit, CaMK-II subunit delta, Calcium / calmodulin dependent protein kinase 2 delta, Calcium / calmodulin dependent protein kinase II delta, Calcium/calmodulin-dependent protein kinase type II subunit delta, D14Ertd420e, DXS1179E, EC 2.7.11.13, EPK 2, KCC2D_HUMAN, KPCA_HUMAN, KPCB_HUMAN, KPCD1_HUMAN, KPCD3_HUMAN, KPCD_HUMAN, KPCE_HUMAN, KPCG_HUMAN, KPCI_HUMAN, KPCL_HUMAN, KPCT_HUMAN, KPCZ_HUMAN, Kinase PKC delta, May-01, MGC 5363, MGC125656, MGC125657, MGC126514, MGC141919, MGC26269, MGC26534, MGC49908, MGC57564, NU, OTTHUMP00000001368, OTTHUMP00000043364, OTTHUMP00000043365, OTTHUMP00000044160, OTTHUMP00000067291, PCKd, PKC, PKC 0, PKC 2, PKC MU, PKC ZETA, PKC d, PKC delta, PKC epsilon, PKC h, PKC lambda, PKC lambda/iota, PKC-A, PKC-B, PKC-L, PKC-alpha, PKC-beta, PKC-gamma, PKCC, PKCE, PKCG, PKCI, PKCM, PKCiota, PKCnu, PKD, PKD 3, PKM-zeta, included, PRK D3, PRKC D, PRKC delta, PRKC iota, PRKC-lambda/iota, PRKCA, PRKCB, PRKCB II, PRKCB1, PRKCB2, PRKCE, PRKCG, PRKCI, PRKCL, PRKCM, PRKCN, PRKCT, PRKCZ, PRKD 1, Pkcea, Pkcz, Prkch, Prkcq, Protein Kinase C alpha, Protein Kinase C delta, Protein kinase C, Protein kinase C alpha type, Protein kinase C beta, Protein kinase C beta type, Protein kinase C delta VIII, Protein kinase C delta type, Protein kinase C epsilon, Protein kinase C epsilon type, Protein kinase C eta, Protein kinase C eta type, Protein kinase C gamma, Protein kinase C gamma polypeptide, Protein kinase C gamma type, Protein kinase C iota, Protein kinase C iota type, Protein kinase C mu, Protein kinase C mu type, Protein kinase C nu, Protein kinase C nu type, Protein kinase C theta, Protein kinase C theta type, Protein kinase C zeta, Protein kinase C zeta form, Protein kinase C zeta type, Protein kinase D, Protein kinase D1, Protein kinase D3, Protein kinase EPK 2, R74924, RATCAMKI, SCA 14, Serine threonine protein kinase, Serine/threonine-protein kinase D1, Serine/threonine-protein kinase D3, Tyrosine protein kinase PRKCD, aPKC-lambda/iota, aPKCzeta, calcium/calmodulin-dependent protein kinase (CaM kinase) II delta, calcium/calmodulin-dependent protein kinase type II delta chain, nPKC-D1, nPKC-delta, nPKC-epsilon, nPKC-eta, nPKC-iota, nPKC-mu, nPKC-nu, nPKC-theta, nPKC-zeta, r14-3-3, zetaPKC