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MW 461 Da, Purity >98%. Potent, cell-permeable, reversible, ATP-competitive, and selective PKC inhibitor (IC50 = 15 nM, rat brain PKC). Blocks antigen driven, but not IL-2 induced, T-cell proliferation. Shows less potent apoptotic effects than Ro-31-8220 (ab120374).

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Images

Chemical Structure - Bisindolylmaleimide X hydrochloride (Ro 31-8425), PKC inhibitor (AB144211), expandable thumbnail

Key facts

CAS number
131848-97-0
Purity
> 98%
Molecular weight
461 Da
Molecular formula
C26H25ClN4O2
PubChem identifier
11539879
Nature
Synthetic

Target data

Recommended products

MW 461 Da, Purity >98%. Potent, cell-permeable, reversible, ATP-competitive, and selective PKC inhibitor (IC50 = 15 nM, rat brain PKC). Blocks antigen driven, but not IL-2 induced, T-cell proliferation. Shows less potent apoptotic effects than Ro-31-8220 (ab120374).

Key facts

Purity
> 98%
PubChem identifier
11539879
Solubility

Soluble in ethanol.

Soluble in DMSO.

Biochemical name
Bisindolylmaleimide X hydrochloride
Biological description

Potent, cell-permeable, reversible, ATP-competitive, and selective PKC inhibitor (IC50 = 15 nM, rat brain PKC). Blocks antigen driven, but not IL-2 induced, T-cell proliferation. Shows less potent apoptotic effects than Ro-31-8220 (ab120374).

Canonical SMILES
CN1C=C(C2=CC=CC=C21)C3=C(C(=O)NC3=O)C4=C5CC(CCN5C6=CC=CC=C64)CN.Cl
InChI
InChI=1S/C26H24N4O2.ClH/c1-29-14-18(16-6-2-4-8-19(16)29)23-24(26(32)28-25(23)31)22-17-7-3-5-9-20(17)30-11-10-15(13-27)12-21(22)30;/h2-9,14-15H,10-13,27H2,1H3,(H,28,31,32);1H
InChIKey
IMBOYWXMTUUYGZ-UHFFFAOYSA-N
IUPAC name
3-[8-(aminomethyl)-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl]-4-(1-methylindol-3-yl)pyrrole-2,5-dione;hydrochloride

Storage

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
Store under desiccating conditions, The product can be stored for up to 12 months

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1 product image

  • Chemical Structure - Bisindolylmaleimide X hydrochloride (Ro 31-8425), PKC inhibitor (ab144211), expandable thumbnail

    Chemical Structure - Bisindolylmaleimide X hydrochloride (Ro 31-8425), PKC inhibitor (ab144211)

    2D chemical structure image of ab144211, Bisindolylmaleimide X hydrochloride (Ro 31-8425), PKC inhibitor

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Product protocols

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