Bisindolylmaleimide XI hydrochloride, PKC inhibitor

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MW 489 Da, Purity >98%. Selective, cell-​permeable protein kinase C (PKC) inhibitor that displays 10-​fold greater selectivity for PKCα (IC₅₀ = 9 nM) and 4-​fold greater selectivity for PKCβI (IC₅₀ = 28 nM) over Ca²⁺-​independent PKCε (IC₅₀ = 108 nM). Enhances cardiac contractility and protection from heart failure. Prevents T-​cell activation and proliferation (IC₅₀s ranging from 30-​150 nM) associated with chronic inflammatory responses in vivo. Also inhibits GRK2, GRK5, and GRK6 (IC₅₀ values are 29, 3.6, and 16 μM, respectively).

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CVID9, D14Ertd420e, KPCA_HUMAN, KPCD_HUMAN, KPCE_HUMAN, KPCL_HUMAN, Kinase PKC delta, May-01, MGC 5363, MGC125656, MGC125657, MGC26269, MGC49908, PCKd, PKC 2, PKC ZETA, PKC d, PKC delta, PKC epsilon, PKC h, PKC-A, PKC-B, PKC-L, PKC-alpha, PKC-beta, PKC-gamma, PKCE, PKCG, PRKC D, PRKC delta, PRKCA, PRKCB, PRKCB1, PRKCB2, PRKCE, PRKCG, PRKCL, PRKCZ, Pkcea, Prkch, Protein Kinase C alpha, Protein Kinase C delta, Protein kinase C, Protein kinase C alpha type, Protein kinase C beta, Protein kinase C delta VIII, Protein kinase C delta type, Protein kinase C epsilon, Protein kinase C epsilon type, Protein kinase C eta, Protein kinase C eta type, Protein kinase C gamma, Protein kinase C zeta, Tyrosine protein kinase PRKCD, nPKC-delta, nPKC-epsilon, nPKC-eta