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AB144572

BIX 02188, MEK5 inhibitor

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MW 412.5 Da, Purity >98%. Potent, selective MEK5 inhibitor (IC50 = 4.3 nM). Blocks phosphorlyation of ERK5, without affecting phosphorylation of ERK1/2. Induces apoptosis in FLT3-ITD cells. Centrally active in vivo..
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Chemical Structure - BIX 02188, MEK5 inhibitor (AB144572)
  • Chemical Structure

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Chemical Structure - BIX 02188, MEK5 inhibitor (AB144572)

2D chemical structure image of ab144572, BIX 02188, MEK5 inhibitor

Key facts

Purity

>98%

Form

Solid

form

Molecular weight

412.5 Da

Molecular formula

C<sub>2</sub><sub>5</sub>H<sub>2</sub><sub>4</sub>N<sub>4</sub>O<sub>2</sub>

PubChem

66524294

Nature

Synthetic

Solubility

Soluble in DMSO to 100 mM

Biochemical name

CID 66524294

Biological description

Potent, selective MEK5 inhibitor (IC50 = 4.3 nM). Blocks phosphorlyation of ERK5, without affecting phosphorylation of ERK1/2. Induces apoptosis in FLT3-ITD cells. Centrally active in vivo.

Canonical smiles

CN(C)CC1=CC(=CC=C1)NC(=C2C3=C(C=C(C=C3)C(=O)N)NC2=O)C4=CC=CC=C4

Isomeric smiles

CN(C)CC1=CC(=CC=C1)N/C(=C\2/C3=C(C=C(C=C3)C(=O)N)NC2=O)/C4=CC=CC=C4

InChi

InChI=1S/C25H24N4O2/c1-29(2)15-16-7-6-10-19(13-16)27-23(17-8-4-3-5-9-17)22-20-12-11-18(24(26)30)14-21(20)28-25(22)31/h3-14,27H,15H2,1-2H3,(H2,26,30)(H,28,31)/b23-22-

InChiKey

FSZPIAXLCCQFCM-FCQUAONHSA-N

IUPAC Name

(3Z)-3-[[3-[(dimethylamino)methyl]anilino]-phenylmethylidene]-2-oxo-1H-indole-6-carboxamide

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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
Store under desiccating conditions|The product can be stored for up to 12 months
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Product protocols

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