BMS 345541, IKK-2 and IKK-1 inhibitor

Be the first to review this product! Submit a review

|

(6 Publications)

MW 255.32 Da, Purity >98%. Highly selective cell permeable IKK-2 and IKK-1 inhibitor (IC₅₀ values are 0.3 and 4 μM for IKK-2 and IKK-1 respectively). Blocks NF-κB-dependent transcription. Shows anti-inflammatory and radiosensitizing effects in vivo. Orally active.

View Alternative Names

39 kDa protein kinase, BC056929, C-2K, C730036H08, CAK, CAK 1, CD11A_HUMAN, CDC2-related protein kinase 5, CDC2L, CDC2L2, CDC2L3, CDC2L4, CDK-activating kinase, CDK-activating kinase 1, CDK11, CDK11 p110, CDK11 p46, CDK11 p58, CDK11A, CDK13_HUMAN, CDK16_HUMAN, CDK7_HUMAN, CDK9_HUMAN, CDKN7, CHED, CHUK1, CLICK I and II related; CLr, CLR, CaMLCK like, Cdc2-related kinase, Cell division cycle 2 like 2 (PITSLRE proteins), Cell division cycle 2-like protein kinase 2, Cell division cycle 2-like protein kinase 4, Cell division cycle 2-like protein kinase 5, Cell division protein kinase 11A, Cell division protein kinase 13, Cell division protein kinase 16, Cell division protein kinase 7, Cell division protein kinase 9, Cholinesterase-related cell division controller, Click I II related, Conserved helix loop ubiquitous kinase, Conserved helix-loop-helix ubiquitous kinase, Cyclin-dependent kinase 11A, Cyclin-dependent kinase 13, Cyclin-dependent kinase 16, Cyclin-dependent kinase 7, Cyclin-dependent kinase 9, DCDC3C, DCK3, DCLK3_HUMAN, Dcamkl3, Doublecortin and CaM kinase like 3, Doublecortin domain-containing protein 3C, Doublecortin-like and CAM kinase-like 3, Doublecortin-like kinase 3, EC 2.7.11.1, EG238564, ER to nucleus signaling 1, ERN1_HUMAN, Endoplasmic reticulum (ER) to nucleus signalling 1, Endoplasmic reticulum-to-nucleus signaling 1, Endoribonuclease, Galactosyltransferase-associated protein kinase p58/GTA, HCAK, Homolog of Xenopus MO15 Cdk activating kinase, I-kappa-B kinase 1, I-kappa-B kinase 2, I-kappa-B kinase alpha, I-kappa-B-kinase beta, IKK 1, IKK a kinase, IKK-alpha, IKK-beta, IKK2, IKKA_HUMAN, IKKB_HUMAN, IMD15, IRE 1P, IRE 1a, IkB kinase alpha subunit, IkBKA, IkBKB, IkappaB kinase, Inhibitor Of Kappa Light Polypeptide Gene Enhancer In B Cells, Inhibitor Of Nuclear Factor Kappa B Kinase Alpha Subunit, Inhibitor of kappa light polypeptide gene enhancer in B cells, kinase beta, Inhibitor of nuclear factor kappa-B kinase subunit alpha, Inhibitor of nuclear factor kappa-B kinase subunit beta, Inositol requiring 1, Inositol requiring 1, S. cerevisiae, homolog of, Inositol requiring enzyme 1, S. cerevisiae, homolog of, Inositol-requiring protein 1, Ire1-alpha, KIAA1765, Kinase subunit of CAK, MGC163277, MGC163279, MO15, MO15, Xenopus, homolog of, MYLK4_HUMAN, Myosin light chain kinase family member 4, NFKBIKA, NFKBIKB, Nuclear Factor Kappa B Inhibitor Kinase Alpha, Nuclear Factor Of Kappa Light Chain Gene Enhancer In B Cells Inhibitor, Nuclear factor NF-kappa-B inhibitor kinase alpha, Nuclear factor NF-kappa-B inhibitor kinase beta, P39 Mo15, PCTAIRE, PCTAIRE protein kinase 1, PCTAIRE-motif protein kinase 1, PCTGAIRE, PCTK1, PITALRE, PITSLRE, PITSLRE B, PITSLRE protein kinase beta, PITSLRE serine/threonine-protein kinase CDC2L2, Protein kinase/endoribonuclease, RGD1309232, RGD1559716, RP11-145H9.1, RP23-427P14.1, STK-1, Serine threonine kinase Stk1, Serine/threonine protein kinase 1, Serine/threonine protein kinase MO15, Serine/threonine protein kinase/endoribonuclease IRE1, Serine/threonine-protein kinase DCLK3, Serine/threonine-protein kinase PCTAIRE-1, Serine/threonine-protein kinase PITALRE, SgK085, Sugen kinase 85, TAK, TCF-16, TFIIH basal transcription factor complex kinase subunit, Tat associated kinase complex catalytic subunit, Transcription factor 16, cell division controller cholinesterase related, cell division cycle 2 like 5, cell division cycle 2 like 5 (cholinesterase related cell division controller), chuk, cyclin-dependent kinase 7 (MO15 homolog, Xenopus laevis, cdk-activating kinase), hCDK13, hCG_16695, hIRE 1p, inositol-requiring enzyme 1, p58GTA