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AB286989

BMS-986020

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MW 482.5 Da, Purity >98%. Potent G protein-coupled lysophosphatidic acid receptor 1 (LPA1) antagonist. LPA receptor is involved in binding of the signaling molecule lysophosphatidic acid, which in turn is involved in a host of diverse biological functions, such as cell proliferation, platelet aggregation, smooth muscle contraction and others.

View Alternative Names

5031439C20, AI326300, EDG 2, Endothelial differentiation gene 2, Endothelial differentiation, lysophosphatidic acid G protein coupled receptor, 2, GPCR 26, Gpcr91, Kdt2, LPA receptor 1, LPA receptor EDG2, LPA-1, LPAR1_HUMAN, Lysophosphatidic acid receptor 1, Lysophosphatidic acid receptor Edg-2, MGC105279, MGC29102, Mrec1.3, Ventricular zone gene 1, rec.1.3, vzg-1

Key facts

CAS number

1257213-50-5

Purity

>98%

Form

Solid

form

Molecular weight

482.5 Da

Molecular formula

C<sub>2</sub><sub>9</sub>H<sub>2</sub><sub>6</sub>N<sub>2</sub>O<sub>5</sub>

PubChem

49792850

Nature

Synthetic

Solubility

DMSO (~20 mg/ml)

Biochemical name

Cyclopropanecarboxylic acid, 1-[4'-[3-methyl-4-[[[(1R)-1-phenylethoxy]carbonyl]amino]-5-isoxazolyl][1,1'-biphenyl]-4-yl]-

Biological description

Potent G protein-coupled lysophosphatidic acid receptor 1 (LPA1) antagonist. LPA receptor is involved in binding of the signaling molecule lysophosphatidic acid, which in turn is involved in a host of diverse biological functions, such as cell proliferation, platelet aggregation, smooth muscle contraction and others.

Canonical smiles

CC1=NOC(=C1NC(=O)OC(C)C2=CC=CC=C2)C3=CC=C(C=C3)C4=CC=C(C=C4)C5(CC5)C(=O)O

Isomeric smiles

CC1=NOC(=C1NC(=O)O[C@H](C)C2=CC=CC=C2)C3=CC=C(C=C3)C4=CC=C(C=C4)C5(CC5)C(=O)O

InChi

InChI=1S/C29H26N2O5/c1-18-25(30-28(34)35-19(2)20-6-4-3-5-7-20)26(36-31-18)23-10-8-21(9-11-23)22-12-14-24(15-13-22)29(16-17-29)27(32)33/h3-15,19H,16-17H2,1-2H3,(H,30,34)(H,32,33)/t19-/m1/s1

InChiKey

GQBRZBHEPUQRPL-LJQANCHMSA-N

IUPAC Name

1-[4-[4-[3-methyl-4-[[(1R)-1-phenylethoxy]carbonylamino]-1,2-oxazol-5-yl]phenyl]phenyl]cyclopropane-1-carboxylic acid

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Product details

This product is manufactured by BioVision, an Abcam company and was previously called B2290 BMS-986020. B2290-25 is the same size as the 25 mg size of ab286989.
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate long-term storage conditions
-20°C
Storage information
This product is air and light sensitive and impurities can occur as a result of air oxidation or due to metabolism by microbes
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

EDG2 also known as LPA-1 LPAR1 or lysophosphatidic acid receptor 1 acts as a receptor for LPA (lysophosphatidic acid) a bioactive lipid mediator. This protein has a molecular mass of approximately 41 kDa. It is part of the G protein-coupled receptor (GPCR) family. EDG2 is mainly expressed in organs such as the brain heart and lungs. It plays an important role in cellular signal transduction by binding LPA which leads to various cellular responses.
Biological function summary

EDG2/LPA-1 influences several cellular processes including cell proliferation migration and survival. It does not function as part of a larger complex; instead it activates intracellular signaling cascades upon LPA binding. This activation leads to downstream effects that regulate processes like cytoskeletal reorganization and gene expression. Its influence extends to immune response modulation making it significant in understanding cellular behavior and communication.

Pathways

EDG2/LPA-1 is important in the mitogen-activated protein kinase (MAPK) and phosphoinositide 3-kinase (PI3K/AKT) signaling pathways. These pathways affect cell growth survival and metabolism showcasing the receptor's importance in cellular regulation. Through these pathways EDG2 interacts with multiple proteins including RAC1 a small GTPase involved in cytoskeletal organization and various kinase enzymes that facilitate signal transduction.

EDG2/LPA-1 has associations with cancer and fibrosis. In cancer the receptor influences tumor growth and metastasis due to its role in cell migration and proliferation. It connects to the matrix metalloproteinases (MMPs) in this context which degrade extracellular matrix components to facilitate cancer cell invasion. Additionally in fibrotic diseases EDG2's influence on fibroblast activity leads to tissue scarring and dysfunctional repair. Understanding these connections helps to explore therapeutic targets meant to modulate EDG2/LPA-1 activity in pathological conditions.
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Product protocols

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Complementary Products

Sample Prep & Detection Kits

AB286929

RNase R

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Primary Antibodies

AB23698

Anti-EDG2 /LPA-1 antibody

Western blot - Anti-EDG2 /LPA-1 antibody (AB23698)

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Proteins & Peptides

AB152354

Recombinant Human EDG2 /LPA-1 protein

SDS-PAGE - Recombinant Human EDG2 /LPA-1 protein (AB152354)

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Cell Lines & Lysates

AB301046

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