BMS-986142

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MW 572.6 Da, Purity >98%. BMS-986142 is a potent, selective, and reversible BTK (Bruton's tyrosine kinase) inhibitor (BTK IC₅₀ = 0.5nM; human WB IC₅₀ = 90 nM). BMS-986142 displays robust efficacy in murine models of rheumatoid arthritis (RA), including collagen-induced arthritis (CIA) and collagen antibody-induced arthritis (CAIA).

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AGMX 1, AT, ATK, Agammaglobulinaemia tyrosine kinase, B lymphocyte kinase, B lymphoid tyrosine kinase, B-cell progenitor kinase, BLK nonreceptor tyrosine kinase, BLK_HUMAN, BMX non receptor tyrosine kinase, BMX_HUMAN, BONE MARROW KINASE, X-LINKED, BPK, BTKL, BTK_HUMAN, Bone marrow tyrosine kinase gene in chromosome X protein, Bruton agammaglobulinemia tyrosine kinase, Bruton tyrosine kinase, Bruton閳ユ獨 Tyrosine Kinase, Cytoplasmic tyrosine-protein kinase BMX, EC 2.7.10.2, EMT, ETK, Epithelial and endothelial tyrosine kinase, Homolog of mouse T cell itk/tsk, IL 2 inducible T cell kinase, IMD 1, ITK_HUMAN, Interleukin 2 inducible T cell kinase, Kinase EMT, LPFS1, LYK, MGC 10442, MGC126257, MGC126258, MGC126261, MGC126262, MGC22473, MODY 11, NKT38, NTK 38, OTTHUMP00000063593, PSCTK 1, PSCTK 2, PSCTK 3, PSCTK5, PTK4, Protein tyrosine kinase BMX, Protein-tyrosine kinase 4, RLK, Resting lymphocyte kinase, T-cell-specific kinase, TSK, TXK tyrosine kinase, TXK_HUMAN, Tyrosine kinase B lymphocyte specific, Tyrosine protein kinase, Tyrosine-protein kinase BLK, Tyrosine-protein kinase BTK, Tyrosine-protein kinase ITK/TSK, Tyrosine-protein kinase Lyk, Tyrosine-protein kinase TXK, XLA, dominant-negative kinase-deficient Brutons tyrosine kinase, p55-BLK, truncated Bruton agammaglobulinemia tyrosine kinase, tyrosine-protein kinase BTK isoform (lacking exon 14