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AB142036

Boc-D-FMK, caspase inhibitor

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(3 Publications)

MW 263.26 Da. Irreversible general caspase inhibitor. Blocks hepatocyte apoptosis in vivo. Active in vitro and in vivo. Cell-permeable.
1 Images
Chemical Structure - Boc-D-FMK, caspase inhibitor (AB142036)
  • Chemical Structure

Lab

Chemical Structure - Boc-D-FMK, caspase inhibitor (AB142036)

2D chemical structure image of ab142036, Boc-D-FMK, caspase inhibitor

Key facts

CAS number

634911-80-1

Form

Solid

form

Molecular weight

263.26 Da

Molecular formula

C<sub>1</sub><sub>1</sub>H<sub>1</sub><sub>8</sub>FNO<sub>5</sub>

PubChem

16760348

Nature

Synthetic

Solubility

Soluble in DMSO to 20 mM

Biochemical name

Boc-D-FMK

Biological description

Irreversible general caspase inhibitor. Blocks hepatocyte apoptosis in vivo. Active in vitro and in vivo. Cell-permeable.

Canonical smiles

CC(C)(C)OC(=O)NC(CC(=O)OC)C(=O)CF

InChi

InChI=1S/C11H18FNO5/c1-11(2,3)18-10(16)13-7(8(14)6-12)5-9(15)17-4/h7H,5-6H2,1-4H3,(H,13,16)

InChiKey

MXOOUCRHWJYCAL-UHFFFAOYSA-N

IUPAC Name

methyl 5-fluoro-3-[(2-methylpropan-2-yl)oxycarbonylamino]-4-oxopentanoate

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Primary Antibodies

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Primary Antibodies

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Anti-GFAP antibody [RM1003] - Astrocyte Marker

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Primary Antibodies

AB109115

Anti-Huntingtin antibody [EPR5526]

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Western blot - Anti-Huntingtin antibody [EPR5526] (AB109115)

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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
Store under desiccating conditions|The product can be stored for up to 12 months
Handling instructions

Need more advice on solubility, usage and handling? Please visit our our product support page for more details.

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Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

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Refer to SDS for further information.

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Product protocols

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Publications (3)

Recent publications for all applications. Explore the full list and refine your search

Journal of biological methods 11:e99010040 PubMed39839094

2025

Reappraisal of the fundamental mechanisms of the sHA14-1 molecule as a Bcl-2/Bcl-XL ligand in the context of anticancer therapy: A cell biological study.

Applications

Unspecified application

Species

Unspecified reactive species

Aoula Moustapha,Pauline Andreu,François Gonzalvez,Delphine Fradin,Jean-Pierre Tissier,Phillippe Diolez,Patrice Xavier Petit

eNeuro 8: PubMed33372032

2021

NGF-Dependent and BDNF-Dependent DRG Sensory Neurons Deploy Distinct Degenerative Signaling Mechanisms.

Applications

Unspecified application

Species

Unspecified reactive species

Andrés de León,Julien Gibon,Philip A Barker

Cell death & disease 6:e1864 PubMed26313915

2015

CD40 ligand induces RIP1-dependent, necroptosis-like cell death in low-grade serous but not serous borderline ovarian tumor cells.

Applications

Unspecified application

Species

Unspecified reactive species

X Qiu,C Klausen,J-C Cheng,P C K Leung
View all publications
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