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AB146161

BRD-7389, p90 ribosomal S6 kinase RSK inhibitor

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MW 366.4 Da. p90 ribosomal S6 kinase RSK inhibitor (IC50 values are 1.2, 1.5 and 2.4 μM for RSK3, RSK1 and RSK2 respectively). Upregulates insulin expression in pancreatic α-cells. Shows reprogramming effects in terminally differentiated cells.
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Chemical Structure - BRD-7389, p90 ribosomal S6 kinase RSK inhibitor (AB146161)
  • Chemical Structure

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Chemical Structure - BRD-7389, p90 ribosomal S6 kinase RSK inhibitor (AB146161)

2D chemical structure image of ab146161, BRD-7389, p90 ribosomal S6 kinase RSK inhibitor

Key facts

Form

Solid

form

Molecular weight

366.4 Da

Molecular formula

C<sub>2</sub><sub>4</sub>H<sub>1</sub><sub>8</sub>N<sub>2</sub>O<sub>2</sub>

PubChem

24870634

Nature

Synthetic

Solubility

Soluble in DMSO to 100 mM

Biochemical name

16-(2-Phenylethylamino)-14-azatetracyclo[7.7.1.02,7.013,17]heptadeca-1(16),2,4,6,9,11,13-heptaene-8,15-dione

Biological description

p90 ribosomal S6 kinase RSK inhibitor (IC50 values are 1.2, 1.5 and 2.4 μM for RSK3, RSK1 and RSK2 respectively). Upregulates insulin expression in pancreatic α-cells. Shows reprogramming effects in terminally differentiated cells.

Canonical smiles

C1=CC=C(C=C1)CCNC2=C3C4C(=NC2=O)C=CC=C4C(=O)C5=CC=CC=C53

InChi

InChI=1S/C24H18N2O2/c27-23-17-10-5-4-9-16(17)21-20-18(23)11-6-12-19(20)26-24(28)22(21)25-14-13-15-7-2-1-3-8-15/h1-12,20,25H,13-14H2

InChiKey

QVEVXIXBUORVGE-UHFFFAOYSA-N

IUPAC Name

16-(2-phenylethylamino)-14-azatetracyclo[7.7.1.02,7.013,17]heptadeca-1(16),2,4,6,9,11,13-heptaene-8,15-dione

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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
Store under desiccating conditions|The product can be stored for up to 12 months
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Product protocols

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