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AB143368

Brivudine, pyrimidine nucleoside analog

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MW 333.13 Da. Pyrimidine nucleoside analog. Antiviral agent (IC50 values are 76 nM and 1.4 μM for herpesvirus and HIV respectively). Blocks DNA polymerase. Binds to heat shock protein HSPB1 and inhibits interaction with its binding partners. Shows anticancer effects in vivo. Orally active.

Key facts

Molecular weight

333.13 Da

Molecular formula

C<sub>1</sub><sub>1</sub>H<sub>1</sub><sub>3</sub>BrN<sub>2</sub>O<sub>5</sub>

PubChem

3183

Nature

Synthetic

Biochemical name

5-(2-Bromoethenyl)-1-[4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidine-2,4-dione

Biological description

Pyrimidine nucleoside analog. Antiviral agent (IC50 values are 76 nM and 1.4 μM for herpesvirus and HIV respectively). Blocks DNA polymerase. Binds to heat shock protein HSPB1 and inhibits interaction with its binding partners. Shows anticancer effects in vivo. Orally active.

Canonical smiles

C1C(C(OC1N2C=C(C(=O)NC2=O)C=CBr)CO)O

InChi

InChI=1S/C11H13BrN2O5/c12-2-1-6-4-14(11(18)13-10(6)17)9-3-7(16)8(5-15)19-9/h1-2,4,7-9,15-16H,3,5H2,(H,13,17,18)

InChiKey

ODZBBRURCPAEIQ-UHFFFAOYSA-N

IUPAC Name

5-(2-bromoethenyl)-1-[4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidine-2,4-dione

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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate long-term storage conditions
Ambient
Storage information
The product can be stored for up to 12 months
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Product protocols

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