BRL 54443, agonist at 5-HT1E and 5-HT1F receptors

Key facts

CAS number

57477-39-1

Purity

>99%

Form

Solid

form

Molecular weight

230.31 Da

Molecular formula

C₁₄H₁₈N₂O

PubChem

2438

Nature

Synthetic

Solubility

Soluble in DMSO to 50 mM

Biochemical name

3-(1-methylpiperidin-4-yl)-1H-indol-5-ol

Biological description

Potent, high affinity and selective agonist at 5-HT1E/1F receptors (pKi values are 8.7 and 8.9, respectively). Displays >30-fold selectivity for human 5-HT over dopamine receptors (pKi values are 7.2 (5-HT1A), 6.9 (5-HT1B), 7.2 (5-HT1D), 5.9 (5-HT2A), 7.0 (5-HT2B), 6.5 (5-HT2C), 6.3 (D2) and 6.2 (D3)).

Canonical smiles

CN1CCC(CC1)C2=CNC3=C2C=C(C=C3)O

InChi

InChI=1S/C14H18N2O/c1-16-6-4-10(5-7-16)13-9-15-14-3-2-11(17)8-12(13)14/h2-3,8-10,15,17H,4-7H2,1H3

InChiKey

WKNFADCGOAHBPG-UHFFFAOYSA-N

IUPAC Name

3-(1-methylpiperidin-4-yl)-1H-indol-5-ol