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AB142262

Bryostatin 1, protein kinase C activator

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MW 905 Da, Purity >98%. Potent protein kinase C activator with high binding affinity (Ki = 1.35 nM). A macrolide lactone. Potently downregulates PKCα, PKCδ and PKCε compared to PMA (ab120297). Range of biological activities. Active in vivo.

View Alternative Names

ATAD5_HUMAN, ATPase family AAA domain containing 5, ATPase family AAA domain-containing protein 5, C17orf41, CVID9, Chromosome fragility-associated gene 1 protein, D14Ertd420e, ELG1, Enhanced level of genomic instability 1 homolog, FRAG1, KPCD_HUMAN, Kinase PKC delta, May-01, MGC49908, PCKd, PKC d, PKC delta, PRKC D, PRKC delta, Protein Kinase C delta, Protein kinase C delta VIII, Protein kinase C delta type, Tyrosine protein kinase PRKCD, chromosome fragility associated gene 1, nPKC-delta

1 Images
Chemical Structure - Bryostatin 1, protein kinase C activator (AB142262)
  • Chemical Structure

Lab

Chemical Structure - Bryostatin 1, protein kinase C activator (AB142262)

2D chemical structure image of ab142262, Bryostatin 1, protein kinase C activator

Key facts

CAS number

83314-01-6

Purity

>98%

Source

Bugula neritina

Molecular weight

905 Da

Molecular formula

C<sub>4</sub><sub>7</sub>H<sub>6</sub><sub>8</sub>O<sub>1</sub><sub>7</sub>

PubChem

5280757

Nature

Native

Solubility

Soluble in DMSO to 25 mM

Soluble in ethanol to 25 mM

Biochemical name

Bryostatin 1

Biological description

Potent protein kinase C activator with high binding affinity (Ki = 1.35 nM). A macrolide lactone. Potently downregulates PKCα, PKCδ and PKCε compared to PMA (ab120297). Range of biological activities. Active in vivo.

Canonical smiles

CCCC=CC=CC(=O)OC1C(=CC(=O)OC)CC2CC(OC(=O)CC(CC3CC(C(C(O3)(CC4CC(=CC(=O)OC)CC(O4)C=CC(C1(O2)O)(C)C)O)(C)C)OC(=O)C)O)C(C)O

Isomeric smiles

CCC/C=C/C=C/C(=O)O[C@H]1/C(=C/C(=O)OC)/C[C@H]2C[C@@H](OC(=O)C[C@@H](C[C@@H]3C[C@@H](C([C@@](O3)(C[C@@H]4C/C(=C/C(=O)OC)/C[C@@H](O4)/C=C/C([C@@]1(O2)O)(C)C)O)(C)C)OC(=O)C)O)[C@@H](C)O

InChi

InChI=1S/C47H68O17/c1-10-11-12-13-14-15-39(51)62-43-31(22-41(53)58-9)21-34-25-37(28(2)48)61-42(54)24-32(50)23-35-26-38(59-29(3)49)45(6,7)46(55,63-35)27-36-19-30(20-40(52)57-8)18-33(60-36)16-17-44(4,5)47(43,56)64-34/h12-17,20,22,28,32-38,43,48,50,55-56H,10-11,18-19,21,23-27H2,1-9H3/b13-12+,15-14+,17-16+,30-20+,31-22+/t28-,32-,33+,34+,35-,36+,37-,38+,43+,46+,47-/m1/s1

InChiKey

MJQUEDHRCUIRLF-TVIXENOKSA-N

IUPAC Name

[(1S,3S,5Z,7R,8E,11S,12S,13E,15S,17R,21R,23R,25S)-25-acetyloxy-1,11,21-trihydroxy-17-[(1R)-1-hydroxyethyl]-5,13-bis(2-methoxy-2-oxoethylidene)-10,10,26,26-tetramethyl-19-oxo-18,27,28,29-tetraoxatetracyclo[21.3.1.13,7.111,15]nonacos-8-en-12-yl] (2E,4E)-octa-2,4-dienoate

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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate long-term storage conditions
-20°C
Storage information
Store under desiccating conditions|The product can be stored for up to 12 months
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Protein kinase C delta (PKCδ) is a serine/threonine kinase known for its role in signal transduction processes. Also termed PRKCD PKCδ has a molecular weight of approximately 78-79 kDa. It is widely expressed across various tissues including the brain heart and lung. As a member of the protein kinase C family PKCδ has a specific C1 domain that allows its activation by diacylglycerol (DAG) and bryostatin 1 a known PKCδ activator. The structure of protein kinase C specifically the C4 region plays a critical role in its activity.
Biological function summary

PKCδ functions in various cellular processes such as apoptosis cell proliferation and differentiation. It is not part of a fixed protein complex but often interacts with adaptor proteins to execute its functions. PKCδ regulates apoptosis through its action on mitochondrial pathways while its role in cell proliferation involves interactions with specific growth factor receptors.

Pathways

PKCδ integrates into the MAPK and JAK/STAT pathways. In the MAPK pathway PKCδ collaborates with proteins like ERK to modulate cellular responses to external stimuli. In the JAK/STAT pathway PKCδ influences gene expression by phosphorylating transcription factors interacting closely with JAK kinases to promote signal transduction.

PKCδ is linked to cancer and cardiovascular diseases. Overexpression of PKCδ associates with certain forms of cancer where it influences tumor cell survival and proliferation. In cardiovascular disorders PKCδ mediates processes like cardiomyocyte apoptosis and inflammation. In these contexts PKCδ interacts with proteins such as p53 in cancer progression and Nox2 in cardiovascular diseases.
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Product protocols

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Primary Antibodies

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