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MW 386.5 Da, Purity >98%. Na+/K+-ATPase inhibitor. Potent steroid receptor coactivators SRC-3 and SRC-1 inhibitor. Induces cell differentiation and apoptosis. Activates AP-1 via JNK. Shows antitumor effects *in vivo.*.

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Images

Chemical Structure - Bufalin, Na+/K+-ATPase inhibitor (AB145636), expandable thumbnail

Key facts

CAS number
465-21-4
Purity
> 98%
Form
Solid
Molecular weight
386.5 Da
Molecular formula
C24H34O4
PubChem identifier
9547215
Nature
Synthetic

Target data

Recommended products

MW 386.5 Da, Purity >98%. Na+/K+-ATPase inhibitor. Potent steroid receptor coactivators SRC-3 and SRC-1 inhibitor. Induces cell differentiation and apoptosis. Activates AP-1 via JNK. Shows antitumor effects *in vivo.*.

Key facts

Purity
> 98%
PubChem identifier
9547215
Solubility

Soluble in ethanol to 50 mM (with warming).

Soluble in DMSO to 50 mM.

Biochemical name
Bufalin
Biological description

Na+/K+-ATPase inhibitor. Potent steroid receptor coactivators SRC-3 and SRC-1 inhibitor. Induces cell differentiation and apoptosis. Activates AP-1 via JNK. Shows antitumor effects *in vivo.*

Canonical SMILES
CC12CCC(CC1CCC3C2CCC4(C3(CCC4C5=COC(=O)C=C5)O)C)O
Isomeric SMILES
C[C@]12CC[C@@H](C[C@H]1CC[C@@H]3[C@@H]2CC[C@]4([C@@]3(CC[C@@H]4C5=COC(=O)C=C5)O)C)O
InChI
InChI=1S/C24H34O4/c1-22-10-7-17(25)13-16(22)4-5-20-19(22)8-11-23(2)18(9-12-24(20,23)27)15-3-6-21(26)28-14-15/h3,6,14,16-20,25,27H,4-5,7-13H2,1-2H3/t16-,17+,18-,19+,20-,22+,23-,24+/m1/s1
InChIKey
QEEBRPGZBVVINN-BMPKRDENSA-N
IUPAC name
5-[(3S,5R,8R,9S,10S,13R,14S,17R)-3,14-dihydroxy-10,13-dimethyl-1,2,3,4,5,6,7,8,9,11,12,15,16,17-tetradecahydrocyclopenta[a]phenanthren-17-yl]pyran-2-one

Storage

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
Store under desiccating conditions, The product can be stored for up to 12 months

Notes

This product is manufactured by BioVision, an Abcam company and was previously called 2509 Bufalin. 2509-50 is the same size as the 50 mg size of ab145636.

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1 product image

  • Chemical Structure - Bufalin, Na+/K+-ATPase inhibitor (ab145636), expandable thumbnail

    Chemical Structure - Bufalin, Na+/K+-ATPase inhibitor (ab145636)

    2D chemical structure image of ab145636, Bufalin, Na+/K+-ATPase inhibitor

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can:

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