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AB142489

Bumetanide, Na+/2Cl-/K+ cotransporter inhibitor

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MW 364.4 Da, Purity >98%. Potent, selective Na+/2Cl-/K+ cotransporter inhibitor. Shows 40-fold greater potency than furosemide (). Shows diuretic and anticonvulsant effects *in vivo.* Orally active.

View Alternative Names

CA 12, CA 14, CA 7, CA IV, CA VB, CA-IX, CA-VII, CA-XII, CA-XIV, CA4, CA5B, CA9, CAH12_HUMAN, CAH14_HUMAN, CAH4_HUMAN, CAH5B_HUMAN, CAH7_HUMAN, CAH9_HUMAN, Car4, Carbonate dehydratase IV, Carbonate dehydratase IX, Carbonate dehydratase VB, Carbonate dehydratase VII, Carbonate dehydratase XII, Carbonate dehydratase XIV, Carbonic anhydrase 12, Carbonic anhydrase 14, Carbonic anhydrase 4, Carbonic anhydrase 5B, Carbonic anhydrase 5B, mitochondrial, Carbonic anhydrase 7, Carbonic anhydrase 9, Carbonic anhydrase IX, Carbonic anhydrase VB, Carbonic anhydrase VB, mitochondrial, Carbonic anhydrase VII, Carbonic anhydrase XII, Carbonic anhydrase XIV, Carbonic dehydratase, Carbonic dehydratase IV, Carbonic dehydratase VII, EC 4.2.1.1, EC=4.2.1.1, FLJ20151, HsT18816, MN, Membrane antigen MN, P54/58N, RCC associated protein G250, RCC-associated antigen G250, RP17, Renal cell carcinoma-associated antigen G250, Retinitis pigmentosa 17 (autosomal dominant), T18816, Tumor antigen HOM-RCC-3.1.3, UNQ690/PRO1335, mitochondrial, pMW1

1 Images
Chemical Structure - Bumetanide, Na+/2Cl-/K+ cotransporter inhibitor (AB142489)
  • Chemical Structure

Lab

Chemical Structure - Bumetanide, Na+/2Cl-/K+ cotransporter inhibitor (AB142489)

2D chemical structure image of ab142489, Bumetanide, Na+/2Cl-/K+ cotransporter inhibitor

Key facts

CAS number

28395-03-1

Purity

>98%

Form

Solid

form

Molecular weight

364.4 Da

Molecular formula

C<sub>1</sub><sub>7</sub>H<sub>2</sub><sub>0</sub>N<sub>2</sub>O<sub>5</sub>S

PubChem

2471

Nature

Synthetic

Solubility

Soluble in DMSO to 50 mM

Soluble in ethanol to 25 mM

Biochemical name

Bumetanide

Biological description

Potent, selective Na+/2Cl-/K+ cotransporter inhibitor. Shows 40-fold greater potency than furosemide (). Shows diuretic and anticonvulsant effects *in vivo.* Orally active.

Canonical smiles

CCCCNC1=C(C(=CC(=C1)C(=O)O)S(=O)(=O)N)OC2=CC=CC=C2

InChi

InChI=1S/C17H20N2O5S/c1-2-3-9-19-14-10-12(17(20)21)11-15(25(18,22)23)16(14)24-13-7-5-4-6-8-13/h4-8,10-11,19H,2-3,9H2,1H3,(H,20,21)(H2,18,22,23)

InChiKey

MAEIEVLCKWDQJH-UHFFFAOYSA-N

IUPAC Name

3-(butylamino)-4-phenoxy-5-sulfamoylbenzoic acid

Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
Ambient
Appropriate long-term storage conditions
Ambient
Storage information
The product can be stored for up to 12 months

Product protocols

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