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MW 276.36 Da, Purity >99%. PRMT1 inhibitor (IC50 = 12.75 μM). Achieve your results faster with highly validated, pure and trusted compounds.

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Images

Chemical Structure - C 7280948, PRMT1 inhibitor (AB144829), expandable thumbnail

Key facts

CAS number
587850-67-7
Purity
> 99%
Form
Solid
Molecular weight
276.36 Da
Molecular formula
C14H16N2O2S
PubChem identifier
833539
Nature
Synthetic

Target data

Alternative names

ANM1_HUMAN, HCP 1, HMT 2, HMT1 (hnRNP methyltransferase S. cerevisiae) like 2, HMT1 hnRNP methyltransferase, HMT1 hnRNP methyltransferase like 2, HMT1 hnRNP methyltransferase like 2 (S. cerevisiae), HRMT1 L2, Heterogeneous nuclear ribonucleoprotein methyltransferase 1 like 2, Heterogeneous nuclear ribonucleoproteins methyltransferase like 2, Histone-arginine N-methyltransferase PRMT1, Human mRNA for suppressor for yeast mutant, Human mRNA for suppressor for yeast mutant complete cds, IR1 B4, Interferon receptor 1-bound protein 4, Mrmt 1, Protein arginine N-methyltransferase 1, Protein arginine methyltransferase 1, R1B4, S. cerevisiae like 2

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MW 276.36 Da, Purity >99%. PRMT1 inhibitor (IC50 = 12.75 μM). Achieve your results faster with highly validated, pure and trusted compounds.

Key facts

Purity
> 99%
PubChem identifier
833539
Solubility

Soluble in DMSO to 50 mM.

Biochemical name
4-amino-N-(2-phenylethyl)benzenesulfonamide
Biological description

PRMT1 inhibitor (IC50 = 12.75 μM).

Canonical SMILES
C1=CC=C(C=C1)CCNS(=O)(=O)C2=CC=C(C=C2)N
InChI
InChI=1S/C14H16N2O2S/c15-13-6-8-14(9-7-13)19(17,18)16-11-10-12-4-2-1-3-5-12/h1-9,16H,10-11,15H2
InChIKey
BYWZPUPRVIECEC-UHFFFAOYSA-N
IUPAC name
4-amino-N-(2-phenylethyl)benzenesulfonamide

Storage

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
Store under desiccating conditions

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.
Activity summary

PRMT1 also known as protein arginine methyltransferase 1 is an important enzyme for post-translational modification. With a molecular mass of approximately 41 kDa PRMT1 is involved in the methylation of arginine residues on target proteins. This enzyme is ubiquitously expressed across various tissues indicating its widespread importance in cellular functions. PRMT1 functions in both the nucleus and cytoplasm impacting diverse cellular processes through its enzymatic activity.

Biological function summary

PRMT1 participates in several essential cellular functions including signal transduction gene expression and RNA processing. It methylates histones and non-histone proteins influencing chromatin structure and function. PRMT1 does not normally function as part of a complex but it interacts individually with different substrates to exert its effects. PRMT1 activity is essential in regulating transcriptional activation and repression highlighting its significant role in cellular regulation.

Pathways

PRMT1 plays a central role in the regulation of the glucocorticoid receptor signaling and p53 pathways. In glucocorticoid receptor signaling PRMT1 modifies transcription factors affecting their ability to bind DNA and regulate gene expression. In the p53 pathway PRMT1 methylates p53 itself impacting cell cycle arrest and apoptotic functions. These pathways demonstrate PRMT1’s interaction with other proteins like the p53 protein highlighting its integrative role in essential cellular processes.

Associated diseases and disorders

PRMT1 is implicated in cancer and cardiovascular diseases. Aberrant expression or activity of PRMT1 associates with tumor progression and poor prognosis in cancers making it a target for therapeutic intervention. Additionally PRMT1 contributes to the pathogenesis of cardiovascular diseases by influencing the expression of genes linked to cardiac hypertrophy. PRMT1 interacts with the p53 protein impacting cancer development while also being connected through its regulatory function on p53-associated genes in these diseases.

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1 product image

  • Chemical Structure - C 7280948, PRMT1 inhibitor (ab144829), expandable thumbnail

    Chemical Structure - C 7280948, PRMT1 inhibitor (ab144829)

    2D chemical structure image of ab144829, C 7280948, PRMT1 inhibitor

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Product protocols

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