C16, PKR inhibitor

Key facts

Purity

>98%

Form

Solid

form

Molecular weight

268.3 Da

Molecular formula

C₁₃H₈N₄OS

PubChem

67016828

Nature

Synthetic

Solubility

Soluble in DMSO to 50 mM

Biochemical name

8-(1h-Imidazol-4-ylmethylene)-6,8-dihydrothiazolo[5,4-e]indol-7-one

Biological description

Specific double-stranded RNA-dependent protein kinase (PKR) inhibitor. Prevents PKR-induced neuronal loss in vivo. Inhibits apoptotic PKR/eIF2α signaling pathway in vivo. Neuroprotective, antitumor and anti-inflammatory agent. Active in vivo and in vitro.

Canonical smiles

C1=CC2=C(C3=C1NC(=O)C3=CC4=CN=CN4)SC=N2

Isomeric smiles

C1=CC2=C(C\3=C1NC(=O)/C3=C/C4=CN=CN4)SC=N2

InChi

InChI=1S/C13H8N4OS/c18-13-8(3-7-4-14-5-15-7)11-9(17-13)1-2-10-12(11)19-6-16-10/h1-6H,(H,14,15)(H,17,18)/b8-3+

InChiKey

VFBGXTUGODTSPK-FPYGCLRLSA-N

IUPAC Name

(8E)-8-(1H-imidazol-5-ylmethylidene)-6H-pyrrolo[2,3-g][1,3]benzothiazol-7-one