AB142216

C59, Wnt Antagonist, Wnt signaling pathway inhibitor

Name: C59, Wnt Antagonist, Wnt signaling pathway inhibitor (CAS 1243243-89-1) | Abcam
Brand: Abcam Limited
SKU: AB142216
Price: 130 USD
Availability: InStock

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(19 Publications)

MW 379.5 Da, Purity >97%. Potent Wnt signaling pathway inhibitor. Inhibits porcupine (PORCN) required for Wnt palmitoylation, secretion, and biological activity. Inhibits Wnt-mediated transcription (IC₅₀ = 74 pM) and cell proliferation. Active in vivo..

View Alternative Names

DHOF, FODH, MG61, MGC29687, POR, PORC, PORCN_HUMAN, Probable protein-cysteine N-palmitoyltransferase porcupine, Protein MG61

1 Images

Chemical Structure - C59, Wnt Antagonist, Wnt signaling pathway inhibitor (AB142216)

Chemical Structure

Lab

Chemical Structure - C59, Wnt Antagonist, Wnt signaling pathway inhibitor (AB142216)

2D chemical structure image of ab142216, C59, Wnt Antagonist, Wnt signaling pathway inhibitor

Key facts

CAS number

1243243-89-1

Purity

>97%

Form

Solid

form

Molecular weight

379.5 Da

Molecular formula

C25H21N3O

PubChem

57519544

Nature

Synthetic

Solubility

Soluble in DMSO to 100 mM

Biochemical name

2-(4-(2-methylpyridin-4-yl)phenyl)-N-(4-(pyridin-3-yl)phenyl)acetamide

Biological description

Potent Wnt signaling pathway inhibitor. Inhibits porcupine (PORCN) required for Wnt palmitoylation, secretion, and biological activity. Inhibits Wnt-mediated transcription (IC₅₀ = 74 pM) and cell proliferation. Active in vivo.

Canonical smiles

CC1=NC=CC(=C1)C2=CC=C(C=C2)CC(=O)NC3=CC=C(C=C3)C4=CN=CC=C4

InChi

InChI=1S/C25H21N3O/c1-18-15-22(12-14-27-18)20-6-4-19(5-7-20)16-25(29)28-24-10-8-21(9-11-24)23-3-2-13-26-17-23/h2-15,17H,16H2,1H3,(H,28,29)

InChiKey

KHZOJCQBHJUJFY-UHFFFAOYSA-N

IUPAC Name

2-[4-(2-methylpyridin-4-yl)phenyl]-N-(4-pyridin-3-ylphenyl)acetamide

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Properties and storage information

Shipped at conditions

Ambient - Can Ship with Ice

Appropriate short-term storage conditions

-20°C

Appropriate long-term storage conditions

-20°C

Storage information

Store under desiccating conditions|The product can be stored for up to 12 months

Handling instructions

Need more advice on solubility, usage and handling? Please visit our our product support page for more details.

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

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Product protocols

Visit the General protocols
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Publications (19)

Recent publications for all applications. Explore the full list and refine your search

ACS sensors 9:4626-4636 PubMed39213612

2024

Class-Wide Analysis of Frizzled-Dishevelled Interactions Using BRET Biosensors Reveals Functional Differences among Receptor Paralogs.

Applications

Unspecified application

Species

Unspecified reactive species

Lukas Grätz,Jan H Voss,Gunnar Schulte

Nature communications 14:3346 PubMed37291092

2023

SERCA2 phosphorylation at serine 663 is a key regulator of Ca homeostasis in heart diseases.

Applications

Unspecified application

Species

Unspecified reactive species

Fabrice Gonnot,Laura Boulogne,Camille Brun,Maya Dia,Yves Gouriou,Gabriel Bidaux,Christophe Chouabe,Claire Crola Da Silva,Sylvie Ducreux,Bruno Pillot,Andrea Kaczmarczyk,Christelle Leon,Stephanie Chanon,Coralie Perret,Franck Sciandra,Tanushri Dargar,Vincent Gache,Fadi Farhat,Laurent Sebbag,Thomas Bochaton,Helene Thibault,Michel Ovize,Melanie Paillard,Ludovic Gomez

FASEB journal : official publication of the Federation of American Societies for Experimental Biology 37:e22776 PubMed36688817

2023

Loss of aquaporin 5 contributes to the corneal epithelial pathogenesis via Wnt/β-catenin pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Yihui Wang,Guohu Di,Kaier Zhang,Ying Bai,Xin Cao,Hui Zhao,Dianqiang Wang,Peng Chen

Journal of cellular physiology 238:447-458 PubMed36598878

2023

Inactivation of Sufu in cementoblasts accelerates external tooth root resorption.

Applications

Unspecified application

Species

Unspecified reactive species

Hwajung Choi,Liu Yang,Yudong Liu,Ju-Kyung Jeong,Eui-Sic Cho

Development (Cambridge, England) 149: PubMed36305473

2022

Overactive Wnt5a signaling disrupts hair follicle polarity during mouse skin development.

Applications

Unspecified application

Species

Unspecified reactive species

Laura Simonson,Ethan Oldham,Hao Chang

Journal of experimental & clinical cancer research : CR 41:89 PubMed35272688

2022

Subtypes in pancreatic ductal adenocarcinoma based on niche factor dependency show distinct drug treatment responses.

Applications

Unspecified application

Species

Unspecified reactive species

Tomohiko Shinkawa,Kenoki Ohuchida,Yuki Mochida,Kukiko Sakihama,Chika Iwamoto,Toshiya Abe,Noboru Ideno,Yusuke Mizuuchi,Koji Shindo,Naoki Ikenaga,Taiki Moriyama,Kohei Nakata,Yoshinao Oda,Masafumi Nakamura

eLife 10: PubMed34702444

2021

RNF43 inhibits WNT5A-driven signaling and suppresses melanoma invasion and resistance to the targeted therapy.

Applications

Unspecified application

Species

Unspecified reactive species

Tomasz Radaszkiewicz,Michaela Nosková,Kristína Gömöryová,Olga Vondálová Blanářová,Katarzyna Anna Radaszkiewicz,Markéta Picková,Ráchel Víchová,Tomáš Gybeľ,Karol Kaiser,Lucia Demková,Lucia Kučerová,Tomáš Bárta,David Potěšil,Zbyněk Zdráhal,Karel Souček,Vítězslav Bryja

Molecular oncology 15:1835-1848 PubMed33969605

2021

Reduced WNT5A signaling in melanoma cells favors an amoeboid mode of invasion.

Applications

Unspecified application

Species

Unspecified reactive species

Njainday Pulo Jobe,Lisa Åsberg,Tommy Andersson

ACS pharmacology & translational science 4:1235-1245 PubMed34151213

2021

Quantitative Profiling of WNT-3A Binding to All Human Frizzled Paralogues in HEK293 Cells by NanoBiT/BRET Assessments.

Applications

Unspecified application

Species

Unspecified reactive species

Paweł Kozielewicz,Rawan Shekhani,Stefanie Moser,Carl-Fredrik Bowin,Janine Wesslowski,Gary Davidson,Gunnar Schulte

Pathobiology : journal of immunopathology, molecul 87:327-337 PubMed33254176

2020

miR-6838-5p Affects Cell Growth, Migration, and Invasion by Targeting GPRIN3 via the Wnt/β-Catenin Signaling Pathway in Gastric Cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Weidong Zhou,Xiaoyun Ding,Peihua Jin,Peifei Li

View all publications

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C59, Wnt Antagonist, Wnt signaling pathway inhibitor

Chemical Structure - C59, Wnt Antagonist, Wnt signaling pathway inhibitor (AB142216)

Key facts

CAS number

Purity

Form

Molecular weight

Molecular formula

PubChem

Nature

Solubility

Biochemical name

Biological description

Canonical smiles

InChi

InChiKey

IUPAC Name

Complementary Products

Primary Antibodies

Biochemicals

Primary Antibodies

Primary Antibodies

Properties and storage information

Shipped at conditions

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Storage information

Handling instructions

Product protocols

Publications (19)

Product promise