MW 254.32 Da, Purity >98%. Competitive, irreversible fatty acid synthase (FAS) inhibitor (IC50 = 200 μM). Suppresses expression of neuropeptide Y and agouti-related protein. Antitumor and anti-obesity agent. Active in vivo and in vitro.
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- Molecular and cellular biology 37:2017RNF20 Suppresses Tumorigenesis by Inhibiting the SREBP1c-PTTG1 Axis in Kidney Cancer.Applications:Unspecified applicationReactive species:Unspecified reactive speciesJae Ho Lee et. al.PubMed 28827316
- PloS one 7:e306512012The effects of C75, an inhibitor of fatty acid synthase, on sleep and metabolism in mice.Applications:Unspecified applicationReactive species:Unspecified reactive speciesJacob Pellinen et. al.PubMed 22348016
- Proceedings of the National Academy of Sciences of 102:3972-72005Effect of centrally administered C75, a fatty acid synthase inhibitor, on ghrelin secretion and its downstream effects.Applications:Unspecified applicationReactive species:Unspecified reactive speciesZhiyuan Hu et. al.PubMed 15728730
- The Biochemical journal 388:895-9032005Characterization of the inactivation of rat fatty acid synthase by C75: inhibition of partial reactions and protection by substrates.Applications:Unspecified applicationReactive species:Unspecified reactive speciesAlan R Rendina,Dong ChengPubMed 15715522
Key facts
- CAS number
191282-48-1
- Purity
> 98%
- Form
Solid
- Molecular weight
254.32 Da
- Molecular formula
C14H22O4
- PubChem identifier
9881506
- Nature
Synthetic
Target data
Recommended products
MW 254.32 Da, Purity >98%. Competitive, irreversible fatty acid synthase (FAS) inhibitor (IC50 = 200 μM). Suppresses expression of neuropeptide Y and agouti-related protein. Antitumor and anti-obesity agent. Active in vivo and in vitro.
Key facts
- CAS number
191282-48-1
- Purity
> 98%
- Form
Solid
- Molecular weight
254.32 Da
- Molecular formula
C14H22O4
- PubChem identifier
9881506
- Nature
Synthetic
- Solubility
Soluble in DMSO to 25 mM. Soluble in ethanol to 100 mM.
- Biochemical name
trans-4-Methylene-2-octyl-5-oxotetrahydrofuran-3-carboxylic acid
- Biological description
Competitive, irreversible fatty acid synthase (FAS) inhibitor (IC50 = 200 μM). Suppresses expression of neuropeptide Y and agouti-related protein. Antitumor and anti-obesity agent. Active in vivo and in vitro.
- Canonical SMILES
CCCCCCCCC1C(C(=C)C(=O)O1)C(=O)O
- Isomeric SMILES
CCCCCCCC[C@@H]1[C@H](C(=C)C(=O)O1)C(=O)O
- InChI
InChI=1S/C14H22O4/c1-3-4-5-6-7-8-9-11-12(13(15)16)10(2)14(17)18-11/h11-12H,2-9H2,1H3,(H,15,16)/t11-,12+/m1/s1
- InChIKey
VCWLZDVWHQVAJU-NEPJUHHUSA-N
- IUPAC name
(2R,3S)-4-methylidene-2-octyl-5-oxooxolane-3-carboxylic acid
Storage
- Shipped at conditions
Ambient - Can Ship with Ice
- Appropriate long-term storage conditions
-20°C
- Storage information
Store under desiccating conditions, The product can be stored for up to 12 months
Notes
This product is manufactured by BioVision, an Abcam company and was previously called 1547 FAS Inhibitor, C75. 1547-1 is the same size as the 1 mg size of ab141397.
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Chemical Structure - C75, fatty acid synthase (FAS) inhibitor (ab141397)
2D chemical structure image of ab141397, C75, fatty acid synthase (FAS) inhibitor
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