MW 451.6 g/mol, Purity >99%.
D2-like receptor agonist (Ki values are 0.7 (D2), 1.5 (D3), 9.0 (D4) and 165 nM (D5)). Highly potent at some 5-HT receptors (Ki values are 20 (5-HT1A), 8.7 (5-HT1D), 6.2 (5-HT2A) and 1.2 nM (5-HT2B)). Shows antitumour effects and has antidepressant and anxiolytic properties.
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Key facts
- CAS number
- 81409-90-7
- Purity
- > 99%
- Form
- Solid
- Molecular weight
- 451.6 g/mol
- Nature
- Synthetic
Recommended products
MW 451.6 g/mol, Purity >99%.
D2-like receptor agonist (Ki values are 0.7 (D2), 1.5 (D3), 9.0 (D4) and 165 nM (D5)). Highly potent at some 5-HT receptors (Ki values are 20 (5-HT1A), 8.7 (5-HT1D), 6.2 (5-HT2A) and 1.2 nM (5-HT2B)). Shows antitumour effects and has antidepressant and anxiolytic properties.
Key facts
- CAS number
- 81409-90-7
- Purity
- > 99%
- Form
- Solid
- Molecular weight
- 451.6 g/mol
- Nature
- Synthetic
- Solubility
Soluble in ethanol to 100 mM.
Soluble in DMSO to 100 mM.
- Biological description
D2-like receptor agonist (Ki values are 0.7 (D2), 1.5 (D3), 9.0 (D4) and 165 nM (D5)). Highly potent at some 5-HT receptors (Ki values are 20 (5-HT1A), 8.7 (5-HT1D), 6.2 (5-HT2A) and 1.2 nM (5-HT2B)). Shows antitumour effects and has antidepressant and anxiolytic properties.
- IUPAC name
- N-[3-(Dimethylamino)propyl]-N-[(ethylamino)carbonyl]-6-(2-propenyl)ergoline-8ß-carboxamide
Storage
- Shipped at conditions
- Ambient - Can Ship with Ice
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- +4°C
- Storage information
- The product can be stored for up to 12 months
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2 product images
Chemical Structure - Cabergoline, D2-like receptor agonist (ab120564)
2D chemical structure image of ab120564, Cabergoline, D2-like receptor agonist
Functional Studies - Cabergoline, D2-like receptor agonist (ab120564)
PC12 cells were incubated at 37°C for 30 minutes with vehicle control (0 μM) and different concentrations of cabergoline (ab120564). Increased expression of AKT1 (phospho S473) (ab66138) in PC12 cells correlates with an increase in cabergoline concentration, as described in literature.
Whole cell lysates were prepared with RIPA buffer (containing protease inhibitors and sodium orthovanadate), 10 μg of each were loaded on the gel and the WB was run under reducing conditions. After transfer the membrane was blocked for an hour using 5% BSA before being incubated with ab66138 at 1/1000 dilution and Anti-beta Actin antibody ab8227 at 1 μg/ml overnight at 4°C. Antibody binding was detected using an anti-rabbit antibody conjugated to HRP (Goat Anti-Rabbit IgG H&L (HRP) ab97051) at 1/10000 dilution and visualised using ECL development solution.
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