MW 194.19 Da, Purity >99%. Psychostimulant. Adenosine A1 and A2A receptor antagonist. Inhibits cAMP phosphodiesterases. Activates ryanodine receptor and induces intracellular calcium release.
58-08-2
> 99%
Solid
194.19 Da
C8H10N4O2
2519
Synthetic
A1AR, A1R, A3AR, A3R, AA1R_HUMAN, AA3R_HUMAN, ACEE, ACES_HUMAN, ACLS, AD 026, ADORA 1, ADORA 3, AIS, ANDR_HUMAN, AR, AR8, ARA3, ARACHE, Acetylcholinesterase, Adenosine A3 receptor, Adenosine receptor A1, Adenosine receptor A3, Androgen nuclear receptor variant 2, Androgen receptor, Androgen receptor (dihydrotestosterone receptor; testicular feminization; spinal and bulbar muscular atrophy; Kennedy disease), Apoptosis related acetylcholinesterase, Atherosclerosis, susceptibility to, included, BXR, DHTR, DKFZp686N23123, DNA binding protein, Dihydro testosterone receptor, Dihydrotestosterone receptor (DHTR), ER, ER-alpha, ER-beta, ERR a, ERR-alpha, ERR1 protein, ERR1_HUMAN, ER[a], ER[b], ESR, ESR B, ESR BETA, ESR1_HUMAN, ESRA, ESRL 1, ESRR A, ESTR B, Eag-related protein 1, Era, Erb, Erb2, Estr, Estra, Estradiol Receptor alpha, Estradiol Receptor beta, Estradiol receptor, Estrogen Receptor 1, Estrogen Receptor 2, Estrogen receptor, Estrogen receptor 1 (alpha), Estrogen receptor 2 (ER beta), Estrogen receptor 2 ER beta, Estrogen receptor alpha, Estrogen receptor beta 4, Estrogen receptor related 1, Estrogen receptor-like 1, Estrogen resistance, included, Estrogen-related receptor alpha, Estrra, Ether a go go related potassium channel protein, Ether-a-go-go-related gene potassium channel 1, Ether-a-go-go-related protein 1, GCPS, GLI Kruppel family member GLI 3, GLI Kruppel family member GLI3 (Greig cephalopolysyndactyly syndrome), GLI family zinc finger 3, GLI3 C-terminally truncated form, GLI3 form of 190 kDa, GLI3 form of 83 kDa, GLI3 full length protein, GLI3-190, GLI3-83, GLI3FL, GLI3_HUMAN, GPCR 2, Glioma associated oncogene family zinc finger 3, H-ERG, HDL cholesterol, augmented response of, to hormone replacement, included, HUMARA, HYSP1, IMD42, KCNH2_HUMAN, KD, Kennedy disease (KD), Kv11.1, LQT 2, MGC129539, Myocardial infarction, susceptibility to, included, N-ACHE, NR1F3, NR1I2_HUMAN, NR3A1, NR3A2, NR3B1, NR3C4, Nuclear receptor ROR-gamma, Nuclear receptor RZR-gamma, Nuclear receptor subfamily 1 group F member 3, Nuclear receptor subfamily 1 group I member 2, Nuclear receptor subfamily 3 group A member 1, Nuclear receptor subfamily 3 group A member 2, Nuclear receptor subfamily 3 group B member 1, Nuclear receptor subfamily 3 group C member 4, Nuclear receptor subfamily 3 group C member 4 (NR3C4), ONR 1, OTTHUMP00000017718, OTTHUMP00000017719, OTTHUMP00000215173, OTTHUMP00000215174, OTTHUMP00000215175, Oncogene GLI3, Orphan nuclear receptor PAR 1, Orphan nuclear receptor PXR, PAP A, PAPB, PAR, PAR q, PPD IV, PRR, Potassium channel HERG, Potassium voltage gated channel subfamily H (eag related) member 2, Potassium voltage-gated channel subfamily H member 2, Pregnane X receptor, RAR related orphan nuclear receptor variant 2, RAR related orphan receptor C, isoform a, RAR related orphan receptor gamma, RAR-related orphan receptor C, RDC 7, RNESTROR, RORG_HUMAN, RP11 552M11.7, RZR GAMMA, RZRG, Retinoic acid binding receptor gamma, Retinoid-related orphan receptor-gamma, Ri, Rorc, SBMA, SMAX1, SQT1, SXR, Spinal and bulbar muscular atrophy, Spinal and bulbar muscular atrophy (SBMA), Steroid and xenobiotic receptor, Steroid hormone receptor ERR1, TFM, TGPCR1, TOR, Testicular Feminization (TFM), Transcriptional activator GLI3, Transcriptional repressor GLI3R, Voltage gated potassium channel, subfamily H, member 2, Voltage-gated potassium channel subunit Kv11.1, YT, YT blood group, Zinc finger protein GLI 3, androgen receptor splice variant 4b, bA552M11.5, eag homolog, estrogen receptor related receptor alpha, hERG-1, hERR1, pregnane X nuclear receptor variant 2
MW 194.19 Da, Purity >99%. Psychostimulant. Adenosine A1 and A2A receptor antagonist. Inhibits cAMP phosphodiesterases. Activates ryanodine receptor and induces intracellular calcium release.
58-08-2
> 99%
Solid
194.19 Da
C8H10N4O2
2519
Synthetic
Soluble in water to 100 mM.
Caffeine
Psychostimulant. Adenosine A1 and A2A receptor antagonist. Inhibits cAMP phosphodiesterases. Activates ryanodine receptor and induces intracellular calcium release.
CN1C=NC2=C1C(=O)N(C(=O)N2C)C
InChI=1S/C8H10N4O2/c1-10-4-9-6-5(10)7(13)12(3)8(14)11(6)2/h4H,1-3H3
RYYVLZVUVIJVGH-UHFFFAOYSA-N
1,3,7-trimethylpurine-2,6-dione
Ambient - Can Ship with Ice
Ambient
Ambient
The product can be stored for up to 12 months
This supplementary information is collated from multiple sources and compiled automatically.
Estrogen Receptor (ER) Adenosine A1 Receptor Acetylcholinesterase Gli3 Androgen Receptor PXR Estrogen Related Receptor alpha ROR gamma Adenosine A3 Receptor/A3AR and H-ERG are key proteins with varied functions and expressions throughout the body. ER also known as ESR1 weighs approximately 66 kDa and is found mainly in reproductive tissues. Adenosine A1 Receptor and Adenosine A3 Receptor are under the purinergic receptors group working with adenosine signaling while Acetylcholinesterase hydrolyzes acetylcholine at neuromuscular junctions. Gli3 part of the Gli family is a transcription factor with about 190 kDa mass active in limb development. Androgen Receptor about 110 kDa is important in male reproductive organ formation. PXR an orphan nuclear receptor regulates genes in xenobiotic metabolism. Estrogen Related Receptor alpha and ROR gamma function as nuclear hormone receptors. H-ERG with a mass of roughly 150 kDa operates as a voltage-gated potassium channel important in cardiac function.
These proteins influence numerous cellular processes critical to human development and health maintenance. Estrogen and Androgen Receptors modulate various functions related to growth and reproduction. Adenosine receptors including A1 and A3 engage in cardiovascular and neural activities by affecting heart rate and neurotransmitter release operating as caffeine antagonists due to caffeine's chemical structure mimicking adenosine. Acetylcholinesterase is essential for nerve signal transmission by terminating synaptic activity through acetylcholine breakdown. Gli3 functions in patterning during embryogenesis with interactions in the Hedgehog signaling complex. PXR oversees detoxification pathways while Estrogen Related Receptor alpha and ROR gamma support metabolic regulation and immune responses respectively.
These proteins significantly contribute to their respective biological cascades. Estrogen and Androgen Receptors participate in steroid hormone signaling influencing gene transcription. Adenosine receptors A1 and A3 play roles in purinergic signaling pathways that interact with other G protein-coupled receptors distinctly engaging caffeine in biological processes via caffeine's adenosine-like chemical formula. Acetylcholinesterase fits into the cholinergic pathway primarily affecting neuromuscular junctions and interacting with synaptic proteins. Gli3 functions prominently in the Hedgehog signaling pathway impacting developmental proteins like Sonic hedgehog. H-ERG contributes to cardiac repolarization within the cardiac action potentials pathway.
These proteins serve as markers for various pathological conditions. Estrogen Receptor abnormalities are associated with breast cancer often co-expressing with proteins like HER2. Adenosine A1 and A3 Receptors linked with caffeine adenosine antagonism are studied for their roles in cardiovascular diseases working alongside proteins involved in cardiac stress responses. Acetylcholinesterase inhibitors see use in Alzheimer's disease management requiring proper synaptic chemical structure alteration for therapeutic effects. Dysfunction in Gli3 contributes to developmental disorders such as Greig cephalopolysyndactyly syndrome. H-ERG dysfunctions cause Long QT Syndrome leading to arrhythmias and cardiac complications.
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2D chemical structure image of ab120240, Caffeine, Adenosine antagonist
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