Skip to main content

MW 687.7 Da, Purity >98%. Calmodulin inhibitor (IC50 = 10 nM). Elevates intracellular calcium, independent of calmodulin inhibition. Additionally inhibits adenylyl cylase activity.

Be the first to review this product! Submit a review

Images

Chemical Structure - Calmidazolium chloride, Calmodulin inhibitor (AB120658), expandable thumbnail
  • Immunocytochemistry/ Immunofluorescence - Calmidazolium chloride, Calmodulin inhibitor (AB120658), expandable thumbnail

Publications

Key facts

CAS number

57265-65-3

Purity

> 98%

Form

Solid

Molecular weight

687.7 Da

Molecular formula

C31H23Cl7N2O

PubChem identifier

644274

Nature

Synthetic

Recommended products

MW 687.7 Da, Purity >98%. Calmodulin inhibitor (IC50 = 10 nM). Elevates intracellular calcium, independent of calmodulin inhibition. Additionally inhibits adenylyl cylase activity.

Key facts

Purity

> 98%

PubChem identifier

644274

Solubility

Soluble in ethanol to 100 mM. Soluble in DMSO to 100 mM.

Biochemical name

Calmidazolium chloride

Biological description

Calmodulin inhibitor (IC50 = 10 nM). Elevates intracellular calcium, independent of calmodulin inhibition. Additionally inhibits adenylyl cylase activity.

Canonical SMILES

C1=CC(=CC=C1C(C2=CC=C(C=C2)Cl)N3C=C[N+](=C3)CC(C4=C(C=C(C=C4)Cl)Cl)OCC5=C(C=C(C=C5)Cl)Cl)Cl.[Cl-]

InChI

InChI=1S/C31H23Cl6N2O.ClH/c32-23-6-1-20(2-7-23)31(21-3-8-24(33)9-4-21)39-14-13-38(19-39)17-30(27-12-11-26(35)16-29(27)37)40-18-22-5-10-25(34)15-28(22)36;/h1-16,19,30-31H,17-18H2;1H/q+1;/p-1

InChIKey

YGEIMSMISRCBFF-UHFFFAOYSA-M

IUPAC name

1-[bis(4-chlorophenyl)methyl]-3-[2-(2,4-dichlorophenyl)-2-[(2,4-dichlorophenyl)methoxy]ethyl]imidazol-3-ium;chloride

Storage

Shipped at conditions

Ambient - Can Ship with Ice

Appropriate short-term storage conditions

-20°C

Appropriate long-term storage conditions

-20°C

Storage information

The product can be stored for up to 12 months

Product promise

We are dedicated to supporting your work with high quality reagents and we are here for you every step of the way should you need us.

In the unlikely event of one of our products not working as expected, you are covered by our product promise.

Full details and terms and conditions can be found here:
Terms & Conditions.

2 product images

  • Chemical Structure - Calmidazolium chloride, Calmodulin inhibitor (ab120658), expandable thumbnail

    Chemical Structure - Calmidazolium chloride, Calmodulin inhibitor (ab120658)

    2D chemical structure image of ab120658, Calmidazolium chloride, Calmodulin inhibitor

  • Immunocytochemistry/ Immunofluorescence - Calmidazolium chloride, Calmodulin inhibitor (ab120658), expandable thumbnail

    Immunocytochemistry/ Immunofluorescence - Calmidazolium chloride, Calmodulin inhibitor (ab120658)

    Anti-LC3B antibody - Autophagosome Marker ab48394 staining LC3B (LC3-II) in HeLa cells treated with calmidazolium chloride (ab120658), by ICC/IF. Increase of LC3B (LC3-II) expression correlates with increased concentration of calmidazolium chloride, as described in literature.
    The cells were incubated at 37°C for 6h in media containing different concentrations of ab120658 (calmidazolium chloride) in DMSO, fixed with 4% formaldehyde for 10 minutes at room temperature and blocked with PBS containing 10% goat serum, 0.3 M glycine, 1% BSA and 0.1% tween for 2h at room temperature. Staining of the treated cells with Anti-LC3B antibody - Autophagosome Marker ab48394 (1 µg/ml) was performed overnight at 4°C in PBS containing 1% BSA and 0.1% tween. A DyLight 488 anti-rabbit polyclonal antibody (Goat Anti-Rabbit IgG H&L (DyLight® 488) preadsorbed ab96899) at 1/250 dilution was used as the secondary antibody. Nuclei were counterstained with DAPI and are shown in blue.

Downloads

Product protocols

For this product, it's our understanding that no specific protocols are required. You can:

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com