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AB120658

Calmidazolium chloride, Calmodulin inhibitor

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MW 687.7 Da, Purity >98%. Calmodulin inhibitor (IC50 = 10 nM). Elevates intracellular calcium, independent of calmodulin inhibition. Additionally inhibits adenylyl cylase activity.
2 Images
Immunocytochemistry/ Immunofluorescence - Calmidazolium chloride, Calmodulin inhibitor (AB120658)
  • ICC/IF

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Immunocytochemistry/ Immunofluorescence - Calmidazolium chloride, Calmodulin inhibitor (AB120658)

ab48394 staining LC3B (LC3-II) in HeLa cells treated with calmidazolium chloride (ab120658), by ICC/IF. Increase of LC3B (LC3-II) expression correlates with increased concentration of calmidazolium chloride, as described in literature.
The cells were incubated at 37°C for 6h in media containing different concentrations of ab120658 (calmidazolium chloride) in DMSO, fixed with 4% formaldehyde for 10 minutes at room temperature and blocked with PBS containing 10% goat serum, 0.3 M glycine, 1% BSA and 0.1% tween for 2h at room temperature. Staining of the treated cells with ab48394 (1 µg/ml) was performed overnight at 4°C in PBS containing 1% BSA and 0.1% tween. A DyLight 488 anti-rabbit polyclonal antibody (ab96899) at 1/250 dilution was used as the secondary antibody. Nuclei were counterstained with DAPI and are shown in blue.

Chemical Structure - Calmidazolium chloride, Calmodulin inhibitor (AB120658)
  • Chemical Structure

Lab

Chemical Structure - Calmidazolium chloride, Calmodulin inhibitor (AB120658)

2D chemical structure image of ab120658, Calmidazolium chloride, Calmodulin inhibitor

Key facts

CAS number

57265-65-3

Purity

>98%

Form

Solid

form

Molecular weight

687.7 Da

Molecular formula

C<sub>3</sub><sub>1</sub>H<sub>2</sub><sub>3</sub>Cl<sub>7</sub>N<sub>2</sub>O

PubChem

644274

Nature

Synthetic

Solubility

Soluble in ethanol to 100 mM

Soluble in DMSO to 100 mM

Biochemical name

Calmidazolium chloride

Biological description

Calmodulin inhibitor (IC50 = 10 nM). Elevates intracellular calcium, independent of calmodulin inhibition. Additionally inhibits adenylyl cylase activity.

Canonical smiles

C1=CC(=CC=C1C(C2=CC=C(C=C2)Cl)N3C=C[N+](=C3)CC(C4=C(C=C(C=C4)Cl)Cl)OCC5=C(C=C(C=C5)Cl)Cl)Cl.[Cl-]

InChi

InChI=1S/C31H23Cl6N2O.ClH/c32-23-6-1-20(2-7-23)31(21-3-8-24(33)9-4-21)39-14-13-38(19-39)17-30(27-12-11-26(35)16-29(27)37)40-18-22-5-10-25(34)15-28(22)36;/h1-16,19,30-31H,17-18H2;1H/q+1;/p-1

InChiKey

YGEIMSMISRCBFF-UHFFFAOYSA-M

IUPAC Name

1-[bis(4-chlorophenyl)methyl]-3-[2-(2,4-dichlorophenyl)-2-[(2,4-dichlorophenyl)methoxy]ethyl]imidazol-3-ium;chloride

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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
The product can be stored for up to 12 months
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Product protocols

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