MW 360.4 Da, Purity >98%. SIRT1/2 inhibitor (IC50 values are 56 and 59 μM at SIRT1 and SIRT2 respectively). Class III HDAC inhibitor, with no inhibition of class I and II. Promotes G2 cell cycle arrest. Antitumour activity in vitro and in vivo.
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Key facts
- CAS number
- 14513-15-6
- Purity
- > 98%
- Form
- Solid
- Molecular weight
- 360.4 Da
- Molecular formula
- C21H16N2O2S
- PubChem identifier
- 3246390
- Nature
- Synthetic
Target data
Alternative names
75SirT1, FLJ35621, FLJ37491, HST2, HST2, S. cerevisiae, homolog of, NAD dependent protein deacetylase sirtuin 1, NAD-dependent deacetylase sirtuin-1, NAD-dependent deacetylase sirtuin-2, NAD-dependent protein deacetylase sirtuin-2, OTTHUMP00000198111, OTTHUMP00000198112, Regulatory protein SIR2 homolog 1, Regulatory protein SIR2 homolog 2, SIR1_HUMAN, SIR2 like 1, SIR2, S. cerevisiae, homolog-loke 2, SIR2, S.cerevisiae, homolog-like 1, SIR2-like protein 1, SIR2-like protein 2, SIR2ALPHA, SIR2L, SIR2L1, SIR2L2, SIRT 2, SIRT2_HUMAN, Silencing information regulator 2 like, Silent information regulator 2, Sir2 related protein type 2, SirtT1 75 kDa fragment, Sirtuin (silent mating type information regulation 2 homolog) 1 (S. cerevisiae), Sirtuin (silent mating type information regulation 2 homolog) 2 (S.cerevisiae), Sirtuin 1, Sirtuin 2, Sirtuin type 1, Sirtuin type 2, hSIR2, hSIRT1
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MW 360.4 Da, Purity >98%. SIRT1/2 inhibitor (IC50 values are 56 and 59 μM at SIRT1 and SIRT2 respectively). Class III HDAC inhibitor, with no inhibition of class I and II. Promotes G2 cell cycle arrest. Antitumour activity in vitro and in vivo.
Key facts
- CAS number
- 14513-15-6
- Purity
- > 98%
- Form
- Solid
- Molecular weight
- 360.4 Da
- Molecular formula
- C21H16N2O2S
- PubChem identifier
- 3246390
- Nature
- Synthetic
- Solubility
Soluble in DMSO to 100 mM.
- Biochemical name
- Cambinol
- Biological description
SIRT1/2 inhibitor (IC50 values are 56 and 59 μM at SIRT1 and SIRT2 respectively). Class III HDAC inhibitor, with no inhibition of class I and II. Promotes G2 cell cycle arrest. Antitumour activity in vitro and in vivo.
- Canonical SMILES
- C1=CC=C(C=C1)C2=C(C(=O)NC(=S)N2)CC3=C(C=CC4=CC=CC=C43)O
- InChI
- InChI=1S/C21H16N2O2S/c24-18-11-10-13-6-4-5-9-15(13)16(18)12-17-19(14-7-2-1-3-8-14)22-21(26)23-20(17)25/h1-11,24H,12H2,(H2,22,23,25,26)
- InChIKey
- RVNSQVIUFZVNAU-UHFFFAOYSA-N
- IUPAC name
- 5-[(2-hydroxynaphthalen-1-yl)methyl]-6-phenyl-2-sulfanylidene-1H-pyrimidin-4-one
Storage
- Shipped at conditions
- Ambient - Can Ship with Ice
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- +4°C
- Storage information
- Store under desiccating conditions, The product can be stored for up to 12 months
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
SIRT1 and SIRT2 belong to the family of sirtuins which are NAD+-dependent deacetylases with enzymatic activity that influence chromatin structure and transcriptional regulation. SIRT1 also known as sirtuin 1 weighs approximately 81 kDa and exhibits expression in various tissues including the brain liver and heart. SIRT2 with a mass of about 43 kDa shows high expression in the cytoplasm and nucleus of neurons and adipocytes. Both proteins share significant homology and carry out actions tied to metabolic regulation and the cellular stress response.
- Biological function summary
SIRT1 and SIRT2 play key roles in cellular processes like aging apoptosis and metabolism. SIRT1 operates by deacetylating target proteins and is involved in regulating pathways that reduce oxidative stress and promote DNA repair. It also is part of various protein complexes that coordinate metabolic functions. SIRT2 often associated with the regulation of the cell cycle and cellular differentiation interacts with microtubules and deacetylates proteins localized in cytoplasmic structures.
- Pathways
Both SIRT1 and SIRT2 play important roles in the regulation of cellular pathways such as the insulin signaling pathway and the p53 signaling pathway. In insulin signaling SIRT1 promotes insulin sensitivity by interacting with PGC-1α and other transcription factors to influence gluconeogenesis and lipid metabolism. SIRT2 closely related to cellular stress responses affects pathways linked to cell survival and apoptosis when involved with p53 and FOXO proteins integrating signals from the cellular environment.
- Associated diseases and disorders
SIRT1 and SIRT2 have been implicated in conditions like Type 2 diabetes and neurodegenerative disorders such as Alzheimer's disease. In the case of Type 2 diabetes SIRT1 mediates insulin sensitivity and glucose metabolism which directly affects energy homeostasis. SIRT2 connecting to neurodegenerative disorders negatively regulates processes that lead to neuronal damage with its activity relating to proteins involved in oxidative stress. Both pathways highlight the therapeutic potential of modulating SIRT1 and SIRT2 activities in various pathologies.
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1 product image
Chemical Structure - Cambinol, SIRT1/2 inhibitor (ab141181)
2D chemical structure image of ab141181, Cambinol, SIRT1/2 inhibitor
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