Skip to main content

MW 494.52 g/mol, Purity >98%. Trypsin-like protease inhibitor. Reversibly inhibits airway epithelial sodium channel (ENaC) function (IC50 = 50 nM). Inhibits the production of TNF-α and monocyte chemoattractant protein-1 (MCP-1) by monocytes and disrupts proliferation of pancreatic stellate cells in a rat model of pancreatic fibrosis.

Inhibits transmembrane serine protease TMPRSS2 and blocks entry of SARS-Cov-2 into lung cells

.

Be the first to review this product! Submit a review

Images

Chemical Structure - Camostat mesylate, TMPRSS2 inhibitor (AB145709), expandable thumbnail

Publications

  • Nutrients 14:2022
    Lipid Raft Integrity and Cellular Cholesterol Homeostasis Are Critical for SARS-CoV-2 Entry into Cells.
    Applications:
    Unspecified application
    Reactive species:
    Unspecified reactive species
    Ahmed Bakillah,Fatimah Al Hejji,Abdulrahman Almasaud,Haya Al Jami,Abbas Hawwari,Ali Al Qarni,Jahangir Iqbal,Naif Khalaf Alharbi
    PubMed 36014919
  • The Journal of pharmacology and experimental thera 329:764-742009
    Camostat attenuates airway epithelial sodium channel function in vivo through the inhibition of a channel-activating protease.
    Applications:
    Unspecified application
    Reactive species:
    Unspecified reactive species
    K Coote et. al.
    PubMed 19190233

Key facts

CAS number

59721-29-8

Purity

> 98%

Form

Solid

Molecular weight

494.52 g/mol

Molecular formula

C20H22N4O5CH4O3S

Nature

Synthetic

Target data

Recommended products

  1. Loading...
  2. Loading...
  3. Loading...
  4. Loading...

MW 494.52 g/mol, Purity >98%. Trypsin-like protease inhibitor. Reversibly inhibits airway epithelial sodium channel (ENaC) function (IC50 = 50 nM). Inhibits the production of TNF-α and monocyte chemoattractant protein-1 (MCP-1) by monocytes and disrupts proliferation of pancreatic stellate cells in a rat model of pancreatic fibrosis.

Inhibits transmembrane serine protease TMPRSS2 and blocks entry of SARS-Cov-2 into lung cells

.

Key facts

Purity

> 98%

Solubility

Soluble in water to 100 mM. Soluble in DMSO to 100 mM.

Biological description

Trypsin-like protease inhibitor. Reversibly inhibits airway epithelial sodium channel (ENaC) function (IC50 = 50 nM). Inhibits the production of TNF-α and monocyte chemoattractant protein-1 (MCP-1) by monocytes and disrupts proliferation of pancreatic stellate cells in a rat model of pancreatic fibrosis.

Inhibits transmembrane serine protease TMPRSS2 and blocks entry of SARS-Cov-2 into lung cells

IUPAC name

[4-[2-[2-(Dimethylamino)-2-oxoethoxy]-2-oxoethyl]phenyl] 4-(diaminomethylideneamino)benzoate methanesulfonate

Storage

Shipped at conditions

Ambient - Can Ship with Ice

Appropriate long-term storage conditions

-20°C

Storage information

Store under desiccating conditions, The product can be stored for up to 12 months

Product promise

We are dedicated to supporting your work with high quality reagents and we are here for you every step of the way should you need us.

In the unlikely event of one of our products not working as expected, you are covered by our product promise.

Full details and terms and conditions can be found here:
Terms & Conditions.

1 product image

  • Chemical Structure - Camostat mesylate, TMPRSS2 inhibitor (ab145709), expandable thumbnail

    Chemical Structure - Camostat mesylate, TMPRSS2 inhibitor (ab145709)

    2D chemical structure image of ab145709, Camostat mesylate, TMPRSS2 inhibitor

Downloads

Product protocols

For this product, it's our understanding that no specific protocols are required. You can:

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com