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AB145709

Camostat mesylate, TMPRSS2 inhibitor

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(1 Publication)

MW 494.52 g/mol, Purity >98%. Trypsin-like protease inhibitor. Reversibly inhibits airway epithelial sodium channel (ENaC) function (IC50 = 50 nM). Inhibits the production of TNF-α and monocyte chemoattractant protein-1 (MCP-1) by monocytes and disrupts proliferation of pancreatic stellate cells in a rat model of pancreatic fibrosis.

Inhibits transmembrane serine protease TMPRSS2 and blocks entry of SARS-Cov-2 into lung cells

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1 Images
Chemical Structure - Camostat mesylate, TMPRSS2 inhibitor (AB145709)
  • Chemical Structure

Lab

Chemical Structure - Camostat mesylate, TMPRSS2 inhibitor (AB145709)

2D chemical structure image of ab145709, Camostat mesylate, TMPRSS2 inhibitor

Key facts

CAS number

59721-29-8

Purity

>98%

Form

Solid

form

Molecular weight

494.52 g/mol

Molecular formula

C<sub>2</sub><sub>0</sub>H<sub>2</sub><sub>2</sub>N<sub>4</sub>O<sub>5</sub>.CH<sub>4</sub>O<sub>3</sub>S

Nature

Synthetic

Solubility

Soluble in water to 100 mM

Soluble in DMSO to 100 mM

Biological description

Trypsin-like protease inhibitor. Reversibly inhibits airway epithelial sodium channel (ENaC) function (IC50 = 50 nM). Inhibits the production of TNF-α and monocyte chemoattractant protein-1 (MCP-1) by monocytes and disrupts proliferation of pancreatic stellate cells in a rat model of pancreatic fibrosis.

Inhibits transmembrane serine protease TMPRSS2 and blocks entry of SARS-Cov-2 into lung cells

IUPAC Name

[4-[2-[2-(Dimethylamino)-2-oxoethoxy]-2-oxoethyl]phenyl] 4-(diaminomethylideneamino)benzoate methanesulfonate

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Complementary Products

Biochemicals

AB142181

Cathepsin G Inhibitor, cathepsin G inhibitor

  • 0
  • 0
Primary Antibodies

AB105459

Anti-WIPI2 antibody [2A2]

BOND RX™ Validated|KO Validated|Trial Size

Western blot - Anti-WIPI2 antibody [2A2] (AB105459)

  • 5
  • 4
Primary Antibodies

AB109131

Anti-TMPRSS2 antibody [EPR3862]

RabMAb|Recombinant|KO Validated

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TMPRSS2 antibody [EPR3862] (AB109131)

  • 5
  • 3
Primary Antibodies

AB26

Anti-p53 antibody [PAb 240]

KO Validated|Lab Essentials

Western blot - Anti-p53 antibody [PAb 240] (AB26)

  • 4
  • 56
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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
Store under desiccating conditions|The product can be stored for up to 12 months
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Product protocols

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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Nutrients 14: PubMed36014919

2022

Lipid Raft Integrity and Cellular Cholesterol Homeostasis Are Critical for SARS-CoV-2 Entry into Cells.

Applications

Unspecified application

Species

Unspecified reactive species

Ahmed Bakillah,Fatimah Al Hejji,Abdulrahman Almasaud,Haya Al Jami,Abbas Hawwari,Ali Al Qarni,Jahangir Iqbal,Naif Khalaf Alharbi
View all publications
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Product promise

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