Cantharidic acid, PP2A and PP1 inhibitor

Key facts

CAS number

28874-45-5

Purity

>98%

Form

Solid

form

Molecular weight

214.21 Da

Molecular formula

C₁₀H₁₄O₅

PubChem

121475

Nature

Synthetic

Solubility

Soluble in DMSO to 100 mM

Soluble in ethanol to 25 mM (with warming)

Biochemical name

(1r,2s,3r,4s)-2,3-Dimethyl-7-Oxabicyclo[2.2.1]heptane-2,3-Dicarboxylic Acid

Biological description

Potent, selective PP2A and PP1 inhibitor (IC₅₀ values are 50 nM and 562 nM respectively). Anti-apoptotic agent. Enhances adenovirus transduction efficiency in vitro.

Canonical smiles

CC1(C2CCC(C1(C)C(=O)O)O2)C(=O)O

Isomeric smiles

C[C@]1([C@H]2CC[C@@H]([C@]1(C)C(=O)O)O2)C(=O)O

InChi

InChI=1S/C10H14O5/c1-9(7(11)12)5-3-4-6(15-5)10(9,2)8(13)14/h5-6H,3-4H2,1-2H3,(H,11,12)(H,13,14)/t5-,6+,9+,10-

InChiKey

NMTNUQBORQILRK-XCVPVQRUSA-N

IUPAC Name

(1R,2S,3R,4S)-2,3-dimethyl-7-oxabicyclo[2.2.1]heptane-2,3-dicarboxylic acid