MW 217.29 Da, Purity >98%. Potent ACE inhibitor (IC50 = 21 nM). Reversible and competitive leukotriene A4 hydrolase inhibitor (Ki = 6 μM, leukotriene B4 formation). Vasodilatory and antihypertensive effects in vivo. Orally active.
View Alternative Names
ACE 1, ACE T, ACE-related carboxypeptidase, ACE2_HUMAN, ACEH, ACE_HUMAN, Angiotensin I Converting Enzyme (peptidyl dipeptidase A) 2, Angiotensin I converting enzyme, Angiotensin I converting enzyme 1, Angiotensin I converting enzyme 2, Angiotensin I converting enzyme peptidyl dipeptidase A 1, Angiotensin converting enzyme 2, Angiotensin converting enzyme like protein, Angiotensin converting enzyme somatic isoform, Angiotensin converting enzyme testis specific isoform, Angiotensin forming enzyme precursor, Angiotensin-converting enzyme, Angiotensin-converting enzyme homolog, Angiotensinogenase, Angiotensinogenase precursor, CD 143, CD143 antigen, Carboxycathepsin, Coagulation factor II, Cyclooxygenase, Cyclooxygenase 2b, Cyclooxygenase 3, included, Cyclooxygenase-1, Cyclooxygenase-2, DCP 1, DKFZP434A014, Dipeptidyl carboxypeptidase 1, Dipeptidyl carboxypeptidase I, EC 1.14.99.1, EC 3.4.17, FLJ10761, FLJ17564, Factor II, GRIPGHS, Glucocorticoid-regulated inflammatory Prostaglandin G/H synthase, Glucocorticoid-regulated inflammatory cyclooxygenase, HNFJ2, Kininase II, LKHA4_HUMAN, LTA-4 hydrolase, LTA4, LTA4H, Leukotriene A(4) hydrolase, Leukotriene A-4 hydrolase, MGC26566, MVCD3, Macrophage activation-associated marker protein P71/73, OTTHUMP00000022963, OTTHUMP00000033524, PCOX1, PES-2, PGG/HS, PGH synthase 1, PGH synthase 2, PGH1_HUMAN, PGH2_HUMAN, PGHS-1, PGHS-2, PHS 1, PHS 2, PHS II, PT, PTGHS, PTGS1, PTGS2, Partial COX1 proteins, included, Peptidase P, Peptidyl dipeptidase A, Prepro coagulation factor II, Processed angiotensin-converting enzyme 2, Prostaglandin G/H synthase, Prostaglandin G/H synthase 1, Prostaglandin G/H synthase 2, Prostaglandin G/H synthase 2 precursor, Prostaglandin G/H synthase and cyclooxygenase, Prostaglandin H2 synthase 1, Prostaglandin H2 synthase 2, Prostaglandin-endoperoxide synthase 1, Prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase), Prostaglandin-endoperoxide synthase 2, Prothrombin, REN, RENI_HUMAN, RPRGL2, Ren1, Renin, Renin precursor renal, Serine protease, THPH1, THRB_HUMAN, TIS10, TIS10 protein, Testicular ECA, Thrombin heavy chain, angiotensin I converting enzyme peptidyl-dipeptidase A 1 transcript, angiotensin-forming enzyme, coagulation factor II (thrombin), fj02a10, hCox 2, metalloprotease MPROT 15, prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase), prothrombin B-chain, ptgs2a, soluble form, unp1239, wu:fj02a10
- Chemical Structure
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Chemical Structure - Captopril, ACE inhibitor (AB141333)
2D chemical structure image of ab141333, Captopril, ACE inhibitor
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Biological function summary
These proteins participate in distinct but sometimes overlapping processes critical to maintaining homeostasis. Cyclooxygenase enzymes especially COX2 are often involved in inflammatory pathways and are often overexpressed in response to cytokines and growth factors. ACE1 and ACE2 balance blood pressure and fluid-electrolyte balance with ACE inhibitors like captopril reducing blood pressure by blocking the conversion of angiotensin I to angiotensin II. The renin-angiotensin system of which these proteins are part governs a complex network influencing cardiovascular and renal function. LTA4H plays its role in the inflammatory response generating leukotriene B4 which acts as a powerful leukocyte activator.
Pathways
COX2 COX1 and LTA4H are vital players in the arachidonic acid metabolic pathway influencing inflammation through various eicosanoids. COX enzymes relate to prostaglandin synthesis facilitating pain and fever responses. In contrast ACE1 and renin often linked to the ACE inhibitors' action—like that of captopril—function within the renin-angiotensin-aldosterone system (RAAS) managing blood pressure regulation. These pathways exemplify how hormonal signaling cascades integrate to affect physiological states like hypertension and inflammation.
Publications (1)
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Therapeutic advances in urology 12:1756287220927994 PubMed35173811
2020
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