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AB142653

Carmofur, Antimetabolite agent

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MW 257.26 Da, Purity >97%. Potent acid ceramidase inhibitor (IC50 = 29 nM). Antimetabolite agent. cytostatic pyrimidine analogue derivative of fluorouracil (Asc 2387). Shows antitumor effects in vivo. Orally active.

View Alternative Names

1,8-cineole 2-exo-monooxygenase, AC, ACDase, ASAH, ASAH1_HUMAN, Acid CDase, Acid ceramidase, Acid ceramidase precursor, Acid ceramidase subunit beta, Acylsphingosine deacylase, Albendazole monooxygenase, Albendazole sulfoxidase, Antigen NY-CO-13, BCC7, CP33, CP34, CP3A4_HUMAN, CYP3, CYP3A, CYP3A3, CYP3A4, CYPIIIA3, CYPIIIA4, Cellular tumor antigen p53, Cytochrome P450 3A3, Cytochrome P450 3A4, Cytochrome P450 HLp, Cytochrome P450 NF-25, Cytochrome P450 family 3 subfamily A polypeptide 4, Cytochrome P450 subfamily IIIA polypeptide 4, Cytochrome P450-PCN1, FLJ21558, FLJ22079, FLJ92943, Glucocorticoid inducible P450, HLP, LFS1, MGC126680, Mutant tumor protein 53, N acylsphingosine amidohydrolase (acid ceramidase) 1, N acylsphingosine amidohydrolase 1, N-acylsphingosine amidohydrolase, N-acylsphingosine deacylase, NF 25, Nifedipine oxidase, P450 III steroid inducible, P450 PCN1, P450, family III, P450C3, P53_HUMAN, PHP32, Phosphoprotein p53, Putative 32 kDa heart protein, Quinine 3-monooxygenase, SMAPME, TRP53, Taurochenodeoxycholate 6-alpha-hydroxylase, Tp53, Transformation related protein 53, Tumor protein 53, Tumor protein p53, Tumor suppressor p53, cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 3, cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 4, p53 tumor suppressor, tumor antigen p55

1 Images
Chemical Structure - Carmofur, Antimetabolite agent (AB142653)
  • Chemical Structure

Lab

Chemical Structure - Carmofur, Antimetabolite agent (AB142653)

2D chemical structure image of ab142653, Carmofur, Antimetabolite agent

Key facts

CAS number

61422-45-5

Purity

>97%

Form

Powder

form

Molecular weight

257.26 Da

Molecular formula

C<sub>1</sub><sub>1</sub>H<sub>1</sub><sub>6</sub>FN<sub>3</sub>O<sub>3</sub>

PubChem

2577

Nature

Synthetic

Solubility

Soluble in DMSO to 50 mM

Biochemical name

Carmofur

Biological description

Potent acid ceramidase inhibitor (IC50 = 29 nM). Antimetabolite agent. cytostatic pyrimidine analogue derivative of fluorouracil (Asc 2387) . Shows antitumor effects in vivo. Orally active.

Canonical smiles

CCCCCCNC(=O)N1C=C(C(=O)NC1=O)F

InChi

InChI=1S/C11H16FN3O3/c1-2-3-4-5-6-13-10(17)15-7-8(12)9(16)14-11(15)18/h7H,2-6H2,1H3,(H,13,17)(H,14,16,18)

InChiKey

AOCCBINRVIKJHY-UHFFFAOYSA-N

IUPAC Name

5-fluoro-N-hexyl-2,4-dioxopyrimidine-1-carboxamide

Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate long-term storage conditions
+4°C
Storage information
The product can be stored for up to 12 months

Product protocols

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