MW 214.05 Da, Purity >99%. DNA alkylating agent. Forms interstrand crosslinks in DNA preventing DNA replication and transcription. Inhibitor of glutathione reductase, lipoamide dehydrogenase and trypanothione reductase. Active in vivo.
Images
Publications
Filter by
- Journal of cellular biochemistry 120:882-8932018FOXO1 associated with sensitivity to chemotherapy drugs and glial-mesenchymal transition in glioma.Applications:Unspecified applicationReactive species:Unspecified reactive speciesChao Chen,Guosheng Han,Yanan Li,Zhijian Yue,Laixing Wang,Jianmin LiuPubMed 30216501
Key facts
- CAS number
- 154-93-8
- Purity
- > 99%
- Form
- Solid
- Molecular weight
- 214.05 Da
- Molecular formula
- C5H9Cl2N3O2
- PubChem identifier
- 2578
- Nature
- Synthetic
Target data
Alternative names
ACLS, AHDC, ALDC, ALDH 1, ALDH 11, ALDH class 1, ALDH class 2, ALDH-E1, ALDH-E2, ALDHI, ALDM, ALHDII, Acetaldehyde dehydrogenase 1, Acetaldehyde dehydrogenase 2, Aldehyde dehydrogenase 1, Aldehyde dehydrogenase 1 family member A1, Aldehyde dehydrogenase 1 soluble, Aldehyde dehydrogenase 1A1, Aldehyde dehydrogenase 2 family, Aldehyde dehydrogenase 2 family (mitochondrial), Aldehyde dehydrogenase cytosolic, Aldehyde dehydrogenase liver cytosolic, Aldehyde dehydrogenase mitochondrial, Aldh, Antigen NY-CO-13, BCC7, Cellular tumor antigen p53, DNA binding protein, FLJ92943, GCPS, GLI Kruppel family member GLI 3, GLI Kruppel family member GLI3 (Greig cephalopolysyndactyly syndrome), GLI family zinc finger 3, GLI3 C-terminally truncated form, GLI3 form of 190 kDa, GLI3 form of 83 kDa, GLI3 full length protein, GLI3-190, GLI3-83, GLI3FL, GLI3_HUMAN, GLR1, GLUR, GR, GRD 1, GRase, GSHR_HUMAN, GSR, Glioma associated oncogene family zinc finger 3, Glutathione reductase, Glutathione reductase mitochondrial, Gr-1, LFS1, Liver mitochondrial ALDH, MGC1806, MGC2318, MGC78522, Mitochondrial aldehyde dehydrogenase 2, Mutant tumor protein 53, NF-E2-related factor 2, NF2L2_HUMAN, NRF2, Nfe2l2, Nuclear factor, Nuclear factor (erythroid derived 2) like 2, Nuclear factor erythroid 2-related factor 2, Nuclear factor erythroid derived 2 like 2, Nucleus encoded mitochondrial aldehyde dehydrogenase 2, Oncogene GLI3, P53_HUMAN, PAP A, PAPB, PPD IV, PUMB 1, Phosphoprotein p53, RALDH 1, Retinal dehydrogenase 1, Retinaldehyde dehydrogenase 1, TRP53, Tp53, Transcriptional activator GLI3, Transcriptional repressor GLI3R, Transformation related protein 53, Tumor protein 53, Tumor protein p53, Tumor suppressor p53, Zinc finger protein GLI 3, erythroid derived 2, like 2, nuclear factor erythroid 2 like 2, p53 tumor suppressor, tumor antigen p55
Recommended products
MW 214.05 Da, Purity >99%. DNA alkylating agent. Forms interstrand crosslinks in DNA preventing DNA replication and transcription. Inhibitor of glutathione reductase, lipoamide dehydrogenase and trypanothione reductase. Active in vivo.
Key facts
- CAS number
- 154-93-8
- Purity
- > 99%
- Form
- Solid
- Molecular weight
- 214.05 Da
- Molecular formula
- C5H9Cl2N3O2
- PubChem identifier
- 2578
- Nature
- Synthetic
- Solubility
Soluble in water to 25 mM.
Soluble in ethanol to 100 mM.
Soluble in DMSO to 100 mM.
- Biochemical name
- Carmustine
- Biological description
DNA alkylating agent. Forms interstrand crosslinks in DNA preventing DNA replication and transcription. Inhibitor of glutathione reductase, lipoamide dehydrogenase and trypanothione reductase. Active in vivo.
- Canonical SMILES
- C(CCl)NC(=O)N(CCCl)N=O
- InChI
- InChI=1S/C5H9Cl2N3O2/c6-1-3-8-5(11)10(9-12)4-2-7/h1-4H2,(H,8,11)
- InChIKey
- DLGOEMSEDOSKAD-UHFFFAOYSA-N
- IUPAC name
- 1,3-bis(2-chloroethyl)-1-nitrosourea
Storage
- Shipped at conditions
- Ambient - Can Ship with Ice
- Appropriate short-term storage conditions
- -20°C
- Appropriate long-term storage conditions
- -20°C
- Storage information
- Store under desiccating conditions, The product can be stored for up to 12 months
Product promise
We are dedicated to supporting your work with high quality reagents and we are here for you every step of the way should you need us.
In the unlikely event of one of our products not working as expected, you are covered by our product promise.
Full details and terms and conditions can be found here:
Terms & Conditions.
1 product image
Chemical Structure - Carmustine (BCNU), DNA alkylating agent (ab141911)
2D chemical structure image of ab141911, Carmustine (BCNU), DNA alkylating agent
Downloads
Product protocols
- Visit the general protocols
- Visit troubleshooting
Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.
For licensing inquiries, please contact partnerships@abcam.com