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MW 320.4 Da, Purity >98%. Potent, selective A3 adenosine receptor antagonist (Ki = 37 nM). Reversine (ab120921) analog.

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Key facts

CAS number
863202-33-9
Purity
> 98%
Molecular weight
320.4 Da
Molecular formula
C18H20N6
PubChem identifier
53394567
Nature
Synthetic

Target data

Alternative names

A3AR, A3R, AA3R_HUMAN, AD 026, ADORA 3, ARA3, Adenosine A3 receptor, Adenosine receptor A3, GPCR 2, RP11 552M11.7, TGPCR1, bA552M11.5

Recommended products

MW 320.4 Da, Purity >98%. Potent, selective A3 adenosine receptor antagonist (Ki = 37 nM). Reversine (ab120921) analog.

Key facts

Purity
> 98%
PubChem identifier
53394567
Solubility

Soluble in DMSO to 25 mM.

Biochemical name
2-phenyl-amino-N6-endo-norbornyladenine
Biological description

Potent, selective A3 adenosine receptor antagonist (Ki = 37 nM). Reversine (ab120921) analog.

Canonical SMILES
C1CC2CC1CC2NC3=NC(=NC4=C3NC=N4)NC5=CC=CC=C5
InChI
InChI=1S/C18H20N6/c1-2-4-13(5-3-1)21-18-23-16-15(19-10-20-16)17(24-18)22-14-9-11-6-7-12(14)8-11/h1-5,10-12,14H,6-9H2,(H3,19,20,21,22,23,24)
InChIKey
SLLSODGWHDUMRG-UHFFFAOYSA-N
IUPAC name
6-N-(2-bicyclo[2.2.1]heptanyl)-2-N-phenyl-7H-purine-2,6-diamine

Storage

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
Store under desiccating conditions, The product can be stored for up to 12 months

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.
Activity summary

The Adenosine A3 Receptor (A3AR) also known as A3 adenosine receptor is a member of the G-protein-coupled receptor family. This receptor couples with Gi proteins to exert its effects. The receptor has a molecular weight of approximately 37 kDa. It is expressed in a variety of tissues including the heart liver lung and immune system cells. A3AR's activity involves binding with adenosine molecules which modulates different cellular responses.

Biological function summary

This receptor mediates several processes by interacting with specific ligands. A3AR is not a part of a larger receptor complex but plays a significant role in modulating inflammation and immune response. The receptor contributes to processes like cell proliferation apoptosis and protection against tissue damage. Its activation generally promotes anti-inflammatory effects making it a target for therapeutic research.

Pathways

Many important biological activities are associated with the adenosine signaling pathway. A3AR plays an essential role in the regulation of the inflammatory response and the apoptosis pathway. Through these pathways it interacts with various proteins such as adenylyl cyclase which responds to ligand binding affecting cAMP levels in cells. The receptor's influence on immune cell function links it to other adenosine receptor subtypes.

Associated diseases and disorders

Several conditions exhibit A3AR involvement such as rheumatoid arthritis and cancer. A3AR's anti-inflammatory and pro-apoptotic characteristics make it a point of interest for modulating immune-related disorders. Research also explores its connection with proteins like NF-κB due to their role in inflammation and cancer progression. Overall A3AR remains an active target for therapeutic strategies aiming to control these diseases.

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